INT51107

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.32
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PPP1R1A) carbohydrate metabolic process (PPP1R1A)
Anatomy Link Frequency
endocrine organ 1
PPP1R1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 1 98.12 Very High Very High Very High
agonist 2 97.18 Very High Very High Very High
antagonist 2 91.36 High High
Inflammation 28 82.28 Quite High
depression 24 81.60 Quite High
Catecholamine 2 78.76 Quite High
cytokine 1 76.56 Quite High
Inflammatory marker 2 25.92 Quite Low
cINOD 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 25 97.70 Very High Very High Very High
INFLAMMATION 31 82.28 Quite High
Depression 59 81.60 Quite High
Cardiovascular Disease 11 79.40 Quite High
Increased Venous Pressure Under Development 1 66.52 Quite High
Mental Disorders 1 41.56 Quite Low
Aging 2 10.32 Low Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Nicotine Addiction 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adipose tissue is now regarded as an endocrine organ and secretes several adipokines, such as adiponectin, resistin, plasminogen activating inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) [29]–[31].
Positive_regulation (activating) of inhibitor-1 in endocrine organ associated with obesity
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.32 Pain Relevance 0.35
Most I1 receptor agonists such as moxonidine, rilmenidine, and clonidine can also stimulate alpha 2-adrenoceptors, and the same physiological response is produced by activation of central I1 receptors and alpha 2-adrenoceptors, but their anatomical locations differ.
Positive_regulation (activation) of I1 associated with agonist and clonidine
2) Confidence 0.33 Published 1995 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7677390 Disease Relevance 0 Pain Relevance 0.30

General Comments

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