INT51137
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Several studies have demonstrated that individuals lacking the GSTM1 activity have increased risk of smoking-related diseases (21, 22). | |||||||||||||||
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Allelic loss of the GSTM1 and the GSTP1 (Ile105Val) polymorphism were determined by PCR and RFLP. | |||||||||||||||
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Absence of GSTM1 or GSTT1 can be attributed to absence of the GSTM1 or GSTT1 gene products (null genotype) in approximately 50% and 20% of the Caucasian population, respectively. | |||||||||||||||
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Both benzocaine and etidocaine are more effective at blocking mu1-N1584A current than the wild-type current, while they are less potent at blocking mu1-F1579A current. | |||||||||||||||
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In mutation mu1-N434R, containing the positively charged arginine, the potency of S(-)-bupivacaine was selectively decreased, resulting in a stereoselectivity (stereopotency ratio) of 3. | |||||||||||||||
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To our surprise, neutral benzocaine becomes more effective at blocking mu1-I1575A current than the wild-type current, whereas the opposite is found for etidocaine. | |||||||||||||||
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The affinity of BTX-resistant Na(+) channels mutated in D1-S6 (mu1-N434K, mu1-N437K) toward several LAs is significantly decreased. | |||||||||||||||
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Both benzocaine and etidocaine are more effective at blocking mu1-N1584A current than the wild-type current, while they are less potent at blocking mu1-F1579A current. | |||||||||||||||
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Hypothetically, absence of GST-M1 leaves more glutathione as substrate for the co-expressed GST-P1. | |||||||||||||||
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However, this observation is not relevant at the biological level since the loss of activity of the GSTM1 enzyme, or GSTM1 deficiency, is associated with a deletion carried on both alleles. | |||||||||||||||
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The most recent have concentrated on exteroceptive suppression and suggest that MU inhibition following intra- and perioral stimulation depends on the location of the MU, its background firing rate, the timing of the stimulus, and the task used to drive the unit. | |||||||||||||||
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In contrast to previous data, there was no evidence that GSTM1 deficiency influences melanoma risk in the subgroup of individuals with red or blond hair. | |||||||||||||||
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In a recent study, the protective effect of the heterozygous CCND1 GA genotype on breast cancer risk was restricted to situations of elevated oxidative stress, characterized by absence of antioxidant GSTM1 and GSTT1 enzymes [139]. | |||||||||||||||
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Furthermore, median number of MU was 6504 MU for CAT and 3455 MU for RA. | |||||||||||||||
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In the present study, we have used immunohistochemistry and quantified the results to demonstrate that the levels of delta- and mu-OR subtypes were high in the VZ and SVZ between 11 and 16 gestation weeks (GW) and decreased by 20GW. | |||||||||||||||
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However, the gene deletion of GSTM1 and GSTT1, and the C-allele of NQO1 cannot be ruled out for association with alcoholism.
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Each treatment plan was evaluated with regard to target coverage, dose to OAR, treatment time, number of MU and irradiated normal tissue. | |||||||||||||||
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In this context, number of MU was clearly lower for RA in 8 of 10 patients. | |||||||||||||||
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Dose maximum, treatment time and number of MU showed clearly better results for RA. | |||||||||||||||
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In all other cases, RA got along with obvious less number of MU (figure 4).
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General Comments
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