INT51137

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 39
Total Number 45
Disease Relevance 14.74
Pain Relevance 6.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTM1) small molecule metabolic process (GSTM1) cytoplasm (GSTM1)
Anatomy Link Frequency
neurons 2
chiasm 1
superior 1
hair 1
brain stem 1
GSTM1 (Homo sapiens)
GSTM1 - F1579A (1) GSTM1 - N434K (1)
Pain Link Frequency Relevance Heat
local anesthetic 20 100.00 Very High Very High Very High
Potency 14 100.00 Very High Very High Very High
mu opioid receptor 3 100.00 Very High Very High Very High
Electroencephalography 340 99.98 Very High Very High Very High
Inflammatory response 10 99.60 Very High Very High Very High
Opioid 4 99.36 Very High Very High Very High
fortral 9 99.16 Very High Very High Very High
Morphine 3 99.00 Very High Very High Very High
imagery 62 98.40 Very High Very High Very High
COX2 53 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Conjunctiva Disease 44 99.88 Very High Very High Very High
Stress 39 99.62 Very High Very High Very High
Skin Cancer 10 99.52 Very High Very High Very High
Rheumatoid Arthritis 399 99.42 Very High Very High Very High
INFLAMMATION 110 99.24 Very High Very High Very High
Nicotine Addiction 118 98.68 Very High Very High Very High
Breast Cancer 97 98.36 Very High Very High Very High
Disease 54 98.04 Very High Very High Very High
Metastasis 113 97.88 Very High Very High Very High
Autism 60 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several studies have demonstrated that individuals lacking the GSTM1 activity have increased risk of smoking-related diseases (21, 22).
Negative_regulation (lacking) of GSTM1 associated with nicotine addiction and disease
1) Confidence 0.43 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 1.25 Pain Relevance 0.23
Allelic loss of the GSTM1 and the GSTP1 (Ile105Val) polymorphism were determined by PCR and RFLP.
Negative_regulation (loss) of GSTM1
2) Confidence 0.43 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721922 Disease Relevance 1.17 Pain Relevance 0.25
Absence of GSTM1 or GSTT1 can be attributed to absence of the GSTM1 or GSTT1 gene products (null genotype) in approximately 50% and 20% of the Caucasian population, respectively.
Negative_regulation (absence) of GSTM1
3) Confidence 0.42 Published 2003 Journal Am. J. Med. Genet. A Section Abstract Doc Link 12794689 Disease Relevance 0.41 Pain Relevance 0.36
Both benzocaine and etidocaine are more effective at blocking mu1-N1584A current than the wild-type current, while they are less potent at blocking mu1-F1579A current.
Negative_regulation (blocking) of mu1 (F1579A)
4) Confidence 0.41 Published 1998 Journal Pflugers Arch. Section Abstract Doc Link 9382945 Disease Relevance 0 Pain Relevance 0.24
In mutation mu1-N434R, containing the positively charged arginine, the potency of S(-)-bupivacaine was selectively decreased, resulting in a stereoselectivity (stereopotency ratio) of 3.
Negative_regulation (decreased) of mu1 associated with potency
5) Confidence 0.41 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419561 Disease Relevance 0 Pain Relevance 0.47
To our surprise, neutral benzocaine becomes more effective at blocking mu1-I1575A current than the wild-type current, whereas the opposite is found for etidocaine.
Negative_regulation (blocking) of mu1
6) Confidence 0.41 Published 1998 Journal Pflugers Arch. Section Abstract Doc Link 9382945 Disease Relevance 0 Pain Relevance 0.21
The affinity of BTX-resistant Na(+) channels mutated in D1-S6 (mu1-N434K, mu1-N437K) toward several LAs is significantly decreased.
Negative_regulation (decreased) of mu1 (N434K) associated with local anesthetic
7) Confidence 0.41 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419561 Disease Relevance 0 Pain Relevance 0.47
Both benzocaine and etidocaine are more effective at blocking mu1-N1584A current than the wild-type current, while they are less potent at blocking mu1-F1579A current.
Negative_regulation (blocking) of mu1 (N1584A)
8) Confidence 0.41 Published 1998 Journal Pflugers Arch. Section Abstract Doc Link 9382945 Disease Relevance 0 Pain Relevance 0.24
Hypothetically, absence of GST-M1 leaves more glutathione as substrate for the co-expressed GST-P1.
Negative_regulation (absence) of GST-M1
9) Confidence 0.41 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2245909 Disease Relevance 0.61 Pain Relevance 0
However, this observation is not relevant at the biological level since the loss of activity of the GSTM1 enzyme, or GSTM1 deficiency, is associated with a deletion carried on both alleles.
Negative_regulation (deficiency) of GSTM1
10) Confidence 0.38 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2585099 Disease Relevance 0.45 Pain Relevance 0
The most recent have concentrated on exteroceptive suppression and suggest that MU inhibition following intra- and perioral stimulation depends on the location of the MU, its background firing rate, the timing of the stimulus, and the task used to drive the unit.
Negative_regulation (inhibition) of MU
11) Confidence 0.37 Published 1994 Journal Crit. Rev. Oral Biol. Med. Section Abstract Doc Link 7999950 Disease Relevance 0.08 Pain Relevance 0
In contrast to previous data, there was no evidence that GSTM1 deficiency influences melanoma risk in the subgroup of individuals with red or blond hair.
Negative_regulation (deficiency) of GSTM1 in hair associated with skin cancer
12) Confidence 0.35 Published 2007 Journal Arch. Dermatol. Res. Section Abstract Doc Link 17072629 Disease Relevance 0.82 Pain Relevance 0.35
In a recent study, the protective effect of the heterozygous CCND1 GA genotype on breast cancer risk was restricted to situations of elevated oxidative stress, characterized by absence of antioxidant GSTM1 and GSTT1 enzymes [139].
Negative_regulation (absence) of GSTM1 associated with stress and breast cancer
13) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1851400 Disease Relevance 0.97 Pain Relevance 0
Furthermore, median number of MU was 6504 MU for CAT and 3455 MU for RA.
Negative_regulation (number) of MU associated with rheumatoid arthritis
14) Confidence 0.25 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2949676 Disease Relevance 1.00 Pain Relevance 0
In the present study, we have used immunohistochemistry and quantified the results to demonstrate that the levels of delta- and mu-OR subtypes were high in the VZ and SVZ between 11 and 16 gestation weeks (GW) and decreased by 20GW.
Negative_regulation (decreased) of mu-OR
15) Confidence 0.23 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18455254 Disease Relevance 0.16 Pain Relevance 0.31
However, the gene deletion of GSTM1 and GSTT1, and the C-allele of NQO1 cannot be ruled out for association with alcoholism.


Negative_regulation (deletion) of GSTM1
16) Confidence 0.18 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 18986377 Disease Relevance 0 Pain Relevance 0
Each treatment plan was evaluated with regard to target coverage, dose to OAR, treatment time, number of MU and irradiated normal tissue.
Negative_regulation (number) of MU
17) Confidence 0.18 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2949676 Disease Relevance 0.38 Pain Relevance 0
In this context, number of MU was clearly lower for RA in 8 of 10 patients.
Negative_regulation (number) of MU associated with rheumatoid arthritis
18) Confidence 0.18 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2949676 Disease Relevance 1.31 Pain Relevance 0
Dose maximum, treatment time and number of MU showed clearly better results for RA.
Negative_regulation (number) of MU associated with rheumatoid arthritis
19) Confidence 0.18 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2949676 Disease Relevance 0.55 Pain Relevance 0.09
In all other cases, RA got along with obvious less number of MU (figure 4).


Negative_regulation (number) of MU associated with rheumatoid arthritis
20) Confidence 0.18 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2949676 Disease Relevance 1.13 Pain Relevance 0

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