INT51150

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.80
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
LLCs 1
GON 1
germ cell 1
endometrium 1
leaf 1
HTC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cervicogenic headache 15 100.00 Very High Very High Very High
Dismenorea 8 99.58 Very High Very High Very High
Pain 6 99.12 Very High Very High Very High
pain flank 1 98.88 Very High Very High Very High
methotrexate 10 98.86 Very High Very High Very High
opioid receptor 1 98.84 Very High Very High Very High
MU agonist 3 96.72 Very High Very High Very High
headache 21 96.52 Very High Very High Very High
endometriosis 1 93.76 High High
Angina 1 91.68 High High
Disease Link Frequency Relevance Heat
Post-traumatic Headache 15 100.00 Very High Very High Very High
Cancer 104 99.70 Very High Very High Very High
Dysmenorrhea 6 99.58 Very High Very High Very High
Pain 5 99.12 Very High Very High Very High
Flank Pain 1 98.88 Very High Very High Very High
Germ Cell And Embryonal Neoplasms 2 98.76 Very High Very High Very High
Reprotox - General 3 1 98.50 Very High Very High Very High
Bladder Cancer 2 98.20 Very High Very High Very High
Reprotox - General 1 2 98.02 Very High Very High Very High
Skin Cancer 1 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tumor was diagnosed as primary mediastinal germ cell tumor with mixed seminomatous and non-seminomatous elements due to elevated serum AFP and beta HCG, and the pathological finding of needle biopsy specimen.
Positive_regulation (elevated) of HCG in germ cell associated with cancer and germ cell and embryonal neoplasms
1) Confidence 0.67 Published 2000 Journal Kyobu Geka Section Abstract Doc Link 10770066 Disease Relevance 0.79 Pain Relevance 0.09
Other characteristics are not essential for CGH diagnosis, including pain improvement after greater occipital nerve (GON)/C2 block.
Neg (not) Positive_regulation (essential) of CGH in GON associated with pain and cervicogenic headache
2) Confidence 0.47 Published 1998 Journal Pain Section Abstract Doc Link 9822206 Disease Relevance 1.25 Pain Relevance 1.25
After six months of therapy hCG dose was increased to 2000 IU given twice a week.
Positive_regulation (increased) of hCG
3) Confidence 0.45 Published 2003 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 14595239 Disease Relevance 1.04 Pain Relevance 0.10
In summary, the present results demonstrate that invading endometrial glands in adenomyosis selectively express more hCG/LH receptor mRNA and immunoreactive receptor protein than noninvading glands.
Positive_regulation (more) of hCG in glands associated with dismenorea
4) Confidence 0.45 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7680356 Disease Relevance 0.60 Pain Relevance 0.41
Eighteen of these patients had received a single MTX instillation with a total dose of 10 mg, 7 patients had received a second instillation with 10 mg because of plateauing hCG levels after the first instillation.
Positive_regulation (received) of hCG associated with methotrexate
5) Confidence 0.33 Published 1996 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 8838963 Disease Relevance 0.42 Pain Relevance 0.41
Endometrial thickness can now be evaluated with three-dimensional ultrasound or with the VOCAL system, which can evaluate endometrial volume: however, the mean thickness of the endometrium only has a predictive value for pregnancy at 6 mm, on day 6 or on the day that hCG is triggered.
Positive_regulation (triggered) of hCG in endometrium
6) Confidence 0.30 Published 2008 Journal J Gynecol Obstet Biol Reprod (Paris) Section Abstract Doc Link 18786467 Disease Relevance 0.08 Pain Relevance 0.08
Serum tumor markers (AFP, beta-HCG, and CA19-9) were elevated.
Positive_regulation (elevated) of beta-HCG associated with cancer
7) Confidence 0.08 Published 1996 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 8831215 Disease Relevance 1.10 Pain Relevance 0.10
In the course of a preliminary clarification of the mechanisms of the leaf mixture extract of Aloe buettneri, Justicia insularis, Dicliptera verticillata and Hibiscus macranthus, locally used to regulate the menstrual cycle and to treat dysmenorrhea or cases of infertility in women, pieces of proestrus rat ovary were incubated in the presence of increasing concentration of the plant extract and/or human Chorionic Gonadotropin (hCG).
Positive_regulation (increasing) of hCG in leaf associated with reprotox - general 3 and dismenorea
8) Confidence 0.07 Published 2004 Journal J Ethnopharmacol Section Abstract Doc Link 15120443 Disease Relevance 0.20 Pain Relevance 0.10
Current studies using CGH and cDNA microarray analysis suggest a distinct signature of chromosome gains and losses and gene expression for the different classes of familial breast cancers (BRCA1, BRCA2, and BRCAX) compared to sporadic breast cancers.194 BRCA1 appears to interact with the p53 protein (leading to induction of the cell-cycle inhibitor p21Cip1/WAF1; Fig. 1)195 directly, with the RNA polymerase holoenzyme, with the transcription factor CREB, with two proteins termed BAP1 and BARD1, with ER?
Positive_regulation (using) of CGH associated with breast cancer
9) Confidence 0.04 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.33 Pain Relevance 0
In the presence of hCG, cAMP secretion by both SLCs and LLCs was many-fold higher than in the control group.
Positive_regulation (presence) of hCG in LLCs
10) Confidence 0.02 Published 1999 Journal Anim. Reprod. Sci. Section Abstract Doc Link 10497920 Disease Relevance 0 Pain Relevance 0.43

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