INT51151

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Context Info
Confidence 0.50
First Reported 1993
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.77
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
PPN 3
plasma 2
leukocyte 2
neurons 2
gracile nucleus 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 33 100.00 Very High Very High Very High
qutenza 9 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Neuropeptide 13 99.86 Very High Very High Very High
Sciatic nerve 4 99.40 Very High Very High Very High
Eae 2 98.86 Very High Very High Very High
Neuropathic pain 2 95.00 High High
Inflammation 2 93.12 High High
antagonist 1 92.00 High High
Trigeminal ganglion neurons 2 87.68 High High
Disease Link Frequency Relevance Heat
Injury 3 98.86 Very High Very High Very High
Nervous System Injury 3 95.92 Very High Very High Very High
Sneezing 1 95.36 Very High Very High Very High
Neuropathic Pain 2 95.00 High High
Hypersensitivity 5 94.36 High High
Mucositis 1 93.76 High High
Bronchial Hyperreactivity 3 90.88 High High
Ganglion Cysts 2 86.80 High High
Urological Neuroanatomy 2 81.36 Quite High
Neurogenic Inflammation 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with Rut significantly increased the synthesis and release of CGRP, as shown by the increase in the levels of CGRP mRNA and peptide in the dorsal root ganglia, the density of CGRP immunoreactive nerve fibers in the mesenteric artery, the CGRP content in the spinal cord and the plasma concentration of CGRP, which was markedly attenuated by pretreatment with capsaicin.
Positive_regulation (increase) of Regulation (content) of CGRP in plasma
1) Confidence 0.50 Published 2004 Journal J. Hypertens. Section Body Doc Link 15311112 Disease Relevance 0 Pain Relevance 0
Increased CGRP immunoreactivity was detected in the BTX treated group at day 7, which was not detected at day 3.
Positive_regulation (Increased) of Regulation (immunoreactivity) of CGRP
2) Confidence 0.47 Published 2004 Journal J. Urol. Section Body Doc Link 15371885 Disease Relevance 0.13 Pain Relevance 0
CGRP immunoreactivity was upregulated in the L5 DRG neurons of injured-nerve groups compared with the sham-operated group (P < 0.01).
Positive_regulation (upregulated) of Regulation (immunoreactivity) of CGRP in neurons
3) Confidence 0.47 Published 2008 Journal Spine Section Body Doc Link 18824950 Disease Relevance 0 Pain Relevance 0
After estrogen treatment, CGRP immunoreactivity was markedly increased in the PPN and MPN, whereas Met-Enk immunoreactivity was increased in the MPN.
Positive_regulation (increased) of Regulation (immunoreactivity) of CGRP in PPN associated with calcitonin gene-related peptide
4) Confidence 0.46 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047292 Disease Relevance 0.08 Pain Relevance 0.47
Two weeks after chronic constriction injury of adult rat sciatic nerve, galanin, neuropeptide Y and calcitonin gene-related peptide immunoreactivities were increased in fibers and cells in the gracile nucleus ipsilateral to injury.
Positive_regulation (increased) of Regulation (immunoreactivities) of calcitonin in gracile nucleus associated with eae, injury, neuropeptide, sciatic nerve and calcitonin gene-related peptide
5) Confidence 0.46 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430497 Disease Relevance 0.51 Pain Relevance 0.70
In addition, LPS-induced alterations in airway responses to bronchial constrictors, neutral endopeptidase (NEP) gene expression, leukocyte counts, and SP and calcitonin gene-related peptide (CGRP) levels were determined.
Spec (determined) Positive_regulation (induced) of Regulation (alterations) of CGRP in leukocyte associated with calcitonin gene-related peptide
6) Confidence 0.41 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 12738685 Disease Relevance 0.07 Pain Relevance 0.28
After estrogen treatment, CGRP immunoreactivity was markedly increased in the PPN and MPN, whereas Met-Enk immunoreactivity was increased in the MPN.
Positive_regulation (increased) of in MPN Regulation (immunoreactivity) of CGRP in PPN associated with calcitonin gene-related peptide
7) Confidence 0.16 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047292 Disease Relevance 0.08 Pain Relevance 0.47
The immunoreactivity of substance P (SP) and calcitonin gene-related peptide (CGRP) in the nerve terminals in the nasal mucosa was increased after intranasal application of TDI.
Positive_regulation (increased) of Regulation (immunoreactivity) of calcitonin gene-related peptide in nasal mucosa associated with calcitonin gene-related peptide and substance p
8) Confidence 0.06 Published 1993 Journal Acta Otolaryngol Suppl Section Abstract Doc Link 7680520 Disease Relevance 0.65 Pain Relevance 0.74
Furthermore, the immunoreactivities of substance P and calcitonin gene-related peptide in the bronchoalveolar lavage fluid collected after capsaicin challenge were significantly increased in CS animals.
Positive_regulation (increased) of Regulation (immunoreactivities) of calcitonin associated with qutenza, calcitonin gene-related peptide and substance p
9) Confidence 0.05 Published 1999 Journal J. Appl. Physiol. Section Abstract Doc Link 10562600 Disease Relevance 0.24 Pain Relevance 0.42

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