INT51154

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.77
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grpr) signal transducer activity (Grpr)
Anatomy Link Frequency
sensory neurons 1
projection neurons 1
nerve 1
spinal cord neurons 1
uterine 1
Grpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 14 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
Cholecystokinin 5 99.92 Very High Very High Very High
Spinal cord 5 99.82 Very High Very High Very High
Enkephalin 3 99.76 Very High Very High Very High
Calcitonin gene-related peptide 6 98.76 Very High Very High Very High
projection neuron 3 97.64 Very High Very High Very High
substance P 45 97.44 Very High Very High Very High
agonist 11 96.48 Very High Very High Very High
qutenza 23 94.64 High High
Disease Link Frequency Relevance Heat
Pruritus 20 97.80 Very High Very High Very High
Bordatella Infection 1 97.16 Very High Very High Very High
Targeted Disruption 1 96.08 Very High Very High Very High
Dysmenorrhea 1 94.52 High High
Adhesions 5 93.08 High High
Salivary Gland Disease 4 89.32 High High
INFLAMMATION 1 79.44 Quite High
Cancer 1 76.20 Quite High
Pain 4 73.04 Quite High
Urological Neuroanatomy 3 70.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results demonstrate that rat myometrium expresses functional GRP-preferring Bn receptors whose activation stimulates the phospholipase C pathway, pertussis toxin-insensitive event that contributes to Bn-mediated uterine contractions.
Gene_expression (expresses) of GRP-preferring in uterine associated with bordatella infection and dismenorea
1) Confidence 0.69 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8279518 Disease Relevance 0.19 Pain Relevance 0.15
Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).
Gene_expression (expressed) of gastrin-releasing peptide receptor
2) Confidence 0.41 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.08
Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).
Gene_expression (expressed) of GRP-R
3) Confidence 0.41 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.08
Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).
Gene_expression (expressed) of GRP-R-Med
4) Confidence 0.31 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.08
Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).
Gene_expression (expressed) of GRP-R-Low
5) Confidence 0.31 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.08
Centrally, dorsal spinal cord neurons expressing the gastrin-releasing peptide receptor are required for a wide range of pruritogens to evoke itch [7,8].
Gene_expression (expressing) of gastrin-releasing peptide receptor in spinal cord neurons associated with pruritus and spinal cord
6) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2886013 Disease Relevance 0.67 Pain Relevance 0.86
Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).
Gene_expression (expressed) of GRP-R-Hi
7) Confidence 0.14 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.09
A markedly enhanced expression of bombesin- and leu-enkephalin-(ENK)-like immunoreactivities (LI) in the ganglionic cells and a pronounced increase in the number of nerve fibers showing these immunoreactivities in the submandibular gland tissue following irradiation were observed 10 days after treatment.
Gene_expression (expression) of bombesin in nerve associated with enkephalin
8) Confidence 0.08 Published 1993 Journal Cell Tissue Res. Section Abstract Doc Link 8472309 Disease Relevance 0.32 Pain Relevance 0.29
METHODS: Conscious, fasted rats were given either capsaicin (125 mg/kg subcutaneously) to ablate sensory neurons or indomethacin (5 mg/kg intraperitoneally) to inhibit prostaglandin synthesis, 2 weeks and 30 minutes, respectively, before administration of bombesin (100 micrograms/kg subcutaneously), the dopamine precursor L-DOPA (25 mg/kg intraperitoneally), or the mild irritant 25% ethanol (1 mL orogastric).
Gene_expression (administration) of bombesin in sensory neurons
9) Confidence 0.05 Published 1998 Journal Surgery Section Body Doc Link 9823400 Disease Relevance 0 Pain Relevance 0
Bombesin, neuropeptide Y, neurotensin and dynorphin were less common; and enkephalin was present in only a small percentage of projection neurons.
Gene_expression (common) of Bombesin in projection neurons associated with dynorphin, neuropeptide, projection neuron and enkephalin
10) Confidence 0.05 Published 1993 Journal Brain Res. Section Abstract Doc Link 7680939 Disease Relevance 0.12 Pain Relevance 1.40

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