INT51154

Context Info Confidence 0.69 First Reported 1993 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 10 Total Number 10 Disease Relevance 1.77 Pain Relevance 3.12

plasma membrane (Grpr) signal transducer activity (Grpr)

Anatomy Link Frequency sensory neurons 1 projection neurons 1 nerve 1 spinal cord neurons 1 uterine 1 Grpr (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuropeptide 14 100.00 Dynorphin 4 100.00 Cholecystokinin 5 99.92 Spinal cord 5 99.82 Enkephalin 3 99.76 Calcitonin gene-related peptide 6 98.76 projection neuron 3 97.64 substance P 45 97.44 agonist 11 96.48 qutenza 23 94.64

Disease Link Frequency Relevance Heat Pruritus 20 97.80 Bordatella Infection 1 97.16 Targeted Disruption 1 96.08 Dysmenorrhea 1 94.52 Adhesions 5 93.08 Salivary Gland Disease 4 89.32 INFLAMMATION 1 79.44 Cancer 1 76.20 Pain 4 73.04 Urological Neuroanatomy 3 70.64

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Protein

Mutation

Event

Anatomy

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Speculation

Pain term

Disease term

The results demonstrate that rat myometrium expresses functional GRP-preferring Bn receptors whose activation stimulates the phospholipase C pathway, pertussis toxin-insensitive event that contributes to Bn-mediated uterine contractions.

Gene_expression (expresses) of GRP-preferring in uterine associated with bordatella infection and dismenorea

1) Confidence 0.69 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8279518 Disease Relevance 0.19 Pain Relevance 0.15

Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).

Gene_expression (expressed) of gastrin-releasing peptide receptor

2) Confidence 0.41 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.08

Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).

Gene_expression (expressed) of GRP-R

3) Confidence 0.41 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.08

Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).

Gene_expression (expressed) of GRP-R-Med

4) Confidence 0.31 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.08

Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).

Gene_expression (expressed) of GRP-R-Low

5) Confidence 0.31 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.08

Centrally, dorsal spinal cord neurons expressing the gastrin-releasing peptide receptor are required for a wide range of pruritogens to evoke itch [7,8].

Gene_expression (expressing) of gastrin-releasing peptide receptor in spinal cord neurons associated with pruritus and spinal cord

6) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2886013 Disease Relevance 0.67 Pain Relevance 0.86

Three BALB 3T3 cell lines were made that stably expressed the gastrin-releasing peptide receptor (GRP-R) with receptor numbers varying by 280-fold (GRP-R-Low, GRP-R-Med, and GRP-R-Hi).

Gene_expression (expressed) of GRP-R-Hi

7) Confidence 0.14 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9145910 Disease Relevance 0.09 Pain Relevance 0.09

A markedly enhanced expression of bombesin- and leu-enkephalin-(ENK)-like immunoreactivities (LI) in the ganglionic cells and a pronounced increase in the number of nerve fibers showing these immunoreactivities in the submandibular gland tissue following irradiation were observed 10 days after treatment.

Gene_expression (expression) of bombesin in nerve associated with enkephalin

8) Confidence 0.08 Published 1993 Journal Cell Tissue Res. Section Abstract Doc Link 8472309 Disease Relevance 0.32 Pain Relevance 0.29

METHODS: Conscious, fasted rats were given either capsaicin (125 mg/kg subcutaneously) to ablate sensory neurons or indomethacin (5 mg/kg intraperitoneally) to inhibit prostaglandin synthesis, 2 weeks and 30 minutes, respectively, before administration of bombesin (100 micrograms/kg subcutaneously), the dopamine precursor L-DOPA (25 mg/kg intraperitoneally), or the mild irritant 25% ethanol (1 mL orogastric).

Gene_expression (administration) of bombesin in sensory neurons

9) Confidence 0.05 Published 1998 Journal Surgery Section Body Doc Link 9823400 Disease Relevance 0 Pain Relevance 0

Bombesin, neuropeptide Y, neurotensin and dynorphin were less common; and enkephalin was present in only a small percentage of projection neurons.

Gene_expression (common) of Bombesin in projection neurons associated with dynorphin, neuropeptide, projection neuron and enkephalin

10) Confidence 0.05 Published 1993 Journal Brain Res. Section Abstract Doc Link 7680939 Disease Relevance 0.12 Pain Relevance 1.40

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