INT51158

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 33
Total Number 36
Disease Relevance 15.22
Pain Relevance 13.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tacr1) plasma membrane (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
vascular endothelium 2
spinal 2
leukocyte 2
plasma 1
bladder 1
Tacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 447 100.00 Very High Very High Very High
Dorsal horn 48 100.00 Very High Very High Very High
Cannabinoid 3 100.00 Very High Very High Very High
Inflammation 342 99.60 Very High Very High Very High
Morphine 5 99.48 Very High Very High Very High
Glutamate 34 99.36 Very High Very High Very High
opioid receptor 2 99.28 Very High Very High Very High
Opioid 2 98.96 Very High Very High Very High
gABA 21 98.76 Very High Very High Very High
tolerance 1 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 93 100.00 Very High Very High Very High
INFLAMMATION 386 99.60 Very High Very High Very High
Cystitis 135 99.58 Very High Very High Very High
Pancreatitis 11 99.52 Very High Very High Very High
Vasculitis 88 98.52 Very High Very High Very High
Urological Neuroanatomy 5 98.38 Very High Very High Very High
Neuropathic Pain 24 98.32 Very High Very High Very High
Nervous System Injury 8 98.16 Very High Very High Very High
Pain 126 97.24 Very High Very High Very High
Colitis 9 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that nociception in neonates does not require the NK1 receptor and that the functional maturation of the NK1 receptor allows diversity in both the type of stimuli that activate the pain system and the types of responses elicited by nociceptive stimuli.
Neg (not) Positive_regulation (require) of NK1 receptor associated with nociception and pain
1) Confidence 0.70 Published 2000 Journal Neuroreport Section Abstract Doc Link 10718319 Disease Relevance 0.70 Pain Relevance 0.25
These data suggest that persistent nociceptive effects associated with orofacial cutaneous inflammation depend at least in part on the activation of NK1R.
Positive_regulation (activation) of NK1R associated with nociception and inflammation
2) Confidence 0.69 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14517596 Disease Relevance 0.50 Pain Relevance 0.27
Therefore, it was interesting to observe that treatment with E2 for 3 h caused a parallel increase in both Tac1 and Tacr1 mRNAs.
Positive_regulation (increase) of Tacr1
3) Confidence 0.68 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.16 Pain Relevance 0.25
Caerulein administration caused significant elevations in serum amylase and pancreatic MPO activity, produced histological evidence of pancreatitis, and caused a dramatic increase in NK1R endocytosis.
Positive_regulation (increase) of NK1R associated with pancreatitis and urological neuroanatomy
4) Confidence 0.67 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11668042 Disease Relevance 0.85 Pain Relevance 0.37
SP-induced NK1 receptor endocytosis was inhibited by the specific NK1 receptor antagonist, SR140333.
Positive_regulation (induced) of NK1 receptor associated with antagonist and substance p
5) Confidence 0.63 Published 1996 Journal Histochem. Cell Biol. Section Abstract Doc Link 8985744 Disease Relevance 0 Pain Relevance 0.50
CONCLUSION: Increased levels of NK1 receptor-encoding mRNA within the bladder vascular endothelium suggests the up-regulation of NK1 receptor as a putative factor in the pathogenesis of pain related to IC.
Positive_regulation (regulation) of NK1 receptor in vascular endothelium
6) Confidence 0.56 Published 1998 Journal Br J Urol Section Body Doc Link 9488063 Disease Relevance 0.07 Pain Relevance 0
Regulatory network downstream of NK1R activation
Positive_regulation (activation) of NK1R
7) Confidence 0.53 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0
To determine whether activation of NK1R increases the transcriptional activities of NF-kappaB and Nkx-2.5, an EMSA was performed.
Spec (whether) Positive_regulation (activation) of NK1R
8) Confidence 0.53 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
In this context, an up-regulation of NK1R was found in bladder inflammation [20] and bladder biopsies from cystitis patients present an increase in NK1R density [21], nerves [22], and SP-containing fibers [23].
Positive_regulation (increase) of NK1R in nerves associated with inflammation, cystitis and substance p
9) Confidence 0.53 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 1.61 Pain Relevance 0.88
In contrast, the NK1 receptor is involved in nociceptive responses to high intensity heat and mechanical stimuli, and mediates the second phase of the formalin response in 21-day-old mice.
Positive_regulation (mediates) of NK1 receptor associated with nociception
10) Confidence 0.50 Published 2000 Journal Neuroreport Section Abstract Doc Link 10718319 Disease Relevance 0.53 Pain Relevance 0.26
We propose that mutations in the NK1R gene (tacr1 in humans) could contribute to this disorder, and that drugs that activate NK1R could offer therapeutic relief.
Positive_regulation (activate) of NK1R
11) Confidence 0.47 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19748515 Disease Relevance 0.68 Pain Relevance 0.26
SP activation of NK1R [3] induces a sequential activation of signaling pathways leading to the production of pro-inflammatory mediators [10,16,17] and pro-inflammatory cytokines such as macrophage migration inhibitory factor (MIF) that plays a major role in bladder inflammation [18].
Positive_regulation (activation) of NK1R in bladder associated with inflammatory mediators, inflammation, cytokine and substance p
12) Confidence 0.47 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 1.06 Pain Relevance 0.75
Estrogen increased Tac1 and Tacr1 mRNA after 3 h and decreased Tac1 and Tac4 expression after 24 h.
Positive_regulation (increased) of Tacr1
13) Confidence 0.46 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.09
These observations are in line with our previous work, where we demonstrated that the tachykinin NK1 receptor is not required for antigen-induced inflammatory cell influxes in the airway lumen of mice [49].
Neg (not) Positive_regulation (required) of NK1 receptor in lumen associated with inflammation
14) Confidence 0.45 Published 2009 Journal Respir Res Section Body Doc Link PMC2689186 Disease Relevance 0.40 Pain Relevance 0.24
NK1 receptor activation leads to enhancement of inhibitory neurotransmission in spinal substantia gelatinosa neurons of mouse.
Positive_regulation (activation) of NK1 receptor in spinal associated with substantia gelatinosa neuron
15) Confidence 0.45 Published 2004 Journal Pain Section Title Doc Link 15494183 Disease Relevance 0.09 Pain Relevance 0.67
The nociceptive function of SP is mainly attributed to the activation of NK1 receptors (NK1R) that are expressed on nociceptive projection neurons located in lamina I of the dorsal horn [8,11,12].
Positive_regulation (activation) of NK1R in lamina associated with nociception, dorsal horn, projection neuron and substance p
16) Confidence 0.45 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0.59 Pain Relevance 1.01
In NK1R+/+ mice, IPSC frequency and amplitude were increased after trains of electrical stimulation (Figure 3a,c,d), similar to the results when glutamatergic driving force was blocked (Figure 1a–f & Figure 2c).
Positive_regulation (increased) of NK1R
17) Confidence 0.43 Published 2005 Journal Mol Pain Section Body Doc Link PMC1185563 Disease Relevance 0 Pain Relevance 0.70
Morphine pretreatment blocked the increases in dorsal horn NK1 receptor mRNA levels but did not block the nociception-induced substance P encoding mRNA levels in sensory ganglia.
Positive_regulation (increases) of NK1 receptor in ganglia associated with nociception, dorsal horn, substance p and morphine
18) Confidence 0.39 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846421 Disease Relevance 0.90 Pain Relevance 0.68
Next, we used EMSA to confirm that selected TREs (NF-kappaB and NKx-2.5) are indeed part of the molecular network downstream of NK1R activation.
Positive_regulation (activation) of NK1R
19) Confidence 0.39 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.13 Pain Relevance 0.06
NK1 receptor-encoding mRNA within the vascular endothelium was increased in the biopsies obtained from patients with IC.
Positive_regulation (increased) of NK1 receptor in vascular endothelium
20) Confidence 0.38 Published 1998 Journal Br J Urol Section Body Doc Link 9488063 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox