INT5116

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Context Info
Confidence 0.78
First Reported 1984
Last Reported 2010
Negated 17
Speculated 15
Reported most in Abstract
Documents 670
Total Number 685
Disease Relevance 291.13
Pain Relevance 146.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T cells 121
lymphocytes 46
blood 27
PBMC 22
natural killer cells 18
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7064 100.00 Very High Very High Very High
Inflammation 5108 100.00 Very High Very High Very High
chemokine 870 100.00 Very High Very High Very High
cINOD 327 100.00 Very High Very High Very High
Antinociceptive 52 100.00 Very High Very High Very High
MU agonist 9 100.00 Very High Very High Very High
Intracerebroventricular 1 99.98 Very High Very High Very High
antagonist 454 99.96 Very High Very High Very High
anesthesia 93 99.96 Very High Very High Very High
Serotonin 28 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5728 100.00 Very High Very High Very High
Cancer 2993 100.00 Very High Very High Very High
Necrosis 400 100.00 Very High Very High Very High
Adhesions 334 100.00 Very High Very High Very High
Renal Cancer 131 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 103 100.00 Very High Very High Very High
Syndrome 351 99.98 Very High Very High Very High
Pruritus 114 99.96 Very High Very High Very High
Hyperplasia 148 99.92 Very High Very High Very High
Vomiting 144 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liposome-mediated pcDNA3-IL-2 produced a more powerful antinociceptive effect than pcDNA3-IL-2 alone.
Gene_expression (produced) of IL-2 associated with antinociceptive
1) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044458 Disease Relevance 0.47 Pain Relevance 0.90
The expressed IL-2 profile detected by western blot coincided with its mRNA profile except it was present in the spinal dorsal horn at a higher level.
Gene_expression (expressed) of IL-2 in dorsal horn associated with spinal dorsal horn
2) Confidence 0.78 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044458 Disease Relevance 0.42 Pain Relevance 0.90
There was some additive inhibition of IL-2 receptor expression at the higher concentrations of verapamil and cyclosporine that were tested.
Gene_expression (expression) of IL-2
3) Confidence 0.78 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.44 Pain Relevance 0.16
This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.
Gene_expression (production) of IL-2
4) Confidence 0.78 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.46 Pain Relevance 0.14
Interleukin-2 (IL-2) is a lymphokine produced by T cells whose main function is to stimulate the growth and cytotoxic response of activated T lymphocytes.
Gene_expression (produced) of Interleukin-2 in T lymphocytes
5) Confidence 0.78 Published 2006 Journal Anticancer Drugs Section Abstract Doc Link 16317284 Disease Relevance 0.71 Pain Relevance 0
Interleukin-2 (IL-2) is a lymphokine produced by T cells whose main function is to stimulate the growth and cytotoxic response of activated T lymphocytes.
Gene_expression (produced) of IL-2 in T lymphocytes
6) Confidence 0.78 Published 2006 Journal Anticancer Drugs Section Abstract Doc Link 16317284 Disease Relevance 0.71 Pain Relevance 0
Our present data suggest that the presence of intrauterine bacterial infection may stimulate the intrauterine production of IL-2, and that the stimulation of IL-2 and the reduction of progesterone caused by IL-2 may in part explain the mechanism of uterine contraction associated with intrauterine infection during pregnancy.
Gene_expression (production) of IL-2 in uterine associated with bacterial infection and infection
7) Confidence 0.78 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 8180676 Disease Relevance 0.39 Pain Relevance 0.07
Evaluation of cellular immunity (T-cell subsets, in vitro interleukin-2 production and interleukin-2 receptor expression, T-cell responses to mitogens and antigens, and delayed-hypersensitivity skin tests) as well as clinical and toxicity monitoring was performed prior to treatment, at 2-week intervals during treatment, and after the cessation of treatment.
Gene_expression (expression) of interleukin-2 in skin associated with toxicity and hypersensitivity
8) Confidence 0.77 Published 1988 Journal J. Clin. Immunol. Section Abstract Doc Link 2967309 Disease Relevance 0.61 Pain Relevance 0.33
Increases in interleukin-2 receptor expression were seen on lymphocytes collected on one occasion from each of two patients 30 min postinfusion.
Gene_expression (expression) of interleukin-2 in lymphocytes
9) Confidence 0.77 Published 1988 Journal J. Clin. Immunol. Section Abstract Doc Link 2967309 Disease Relevance 0.86 Pain Relevance 0.29
Studies done 24 hr after infusions revealed increases in interleukin-2 production in one patient, but when pre- and posttreatment values were compared there were no significant changes in numbers of circulating T cells of any phenotype or in T-cell responses to mitogens or antigens.
Gene_expression (production) of interleukin-2 in T-cell
10) Confidence 0.77 Published 1988 Journal J. Clin. Immunol. Section Abstract Doc Link 2967309 Disease Relevance 0.89 Pain Relevance 0.33
Evaluation of cellular immunity (T-cell subsets, in vitro interleukin-2 production and interleukin-2 receptor expression, T-cell responses to mitogens and antigens, and delayed-hypersensitivity skin tests) as well as clinical and toxicity monitoring was performed prior to treatment, at 2-week intervals during treatment, and after the cessation of treatment.
Gene_expression (production) of interleukin-2 in skin associated with toxicity and hypersensitivity
11) Confidence 0.77 Published 1988 Journal J. Clin. Immunol. Section Abstract Doc Link 2967309 Disease Relevance 0.61 Pain Relevance 0.33
The expressed IL-2 protein profile in spinal cord detected by enzyme-linked immunosorbent assay coincided almost exactly with its antinociceptive effect.
Gene_expression (expressed) of IL-2 in spinal cord associated with antinociceptive and spinal cord
12) Confidence 0.77 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.63 Pain Relevance 0.73
These data demonstrated that the IL-2 gene was transfected into spinal cord regions relevant to pain modulation.
Gene_expression (transfected) of IL-2 gene in spinal cord associated with pain and spinal cord
13) Confidence 0.77 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.65 Pain Relevance 0.74
This supported the hypothesis that the therapeutic effect of IL-2 gene was related to IL-2 protein expression.
Gene_expression (expression) of IL-2
14) Confidence 0.77 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.57 Pain Relevance 0.68
Human IL-2 mRNA was detected by in situ hybridization in the spinal pia mater and parenchyma of the lumbar, sacral, thoracic and cervical regions, and gray matter had higher level of IL-2 expression than white matter.
Gene_expression (expression) of IL-2 in parenchyma
15) Confidence 0.77 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.66 Pain Relevance 0.73
The results provide impetus for further investigations in order to clarify the relationship between HVLA manipulation with or without cavitation and the synthesis of IL-2 and other immunoregulatory mediators.


Gene_expression (synthesis) of IL-2
16) Confidence 0.77 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
Constitutive synthesis of IL-2 was determined in supernatants from unstimulated (inducer-free) cultures cultivated in parallel to inducer-activated preparations.
Gene_expression (synthesis) of IL-2
17) Confidence 0.77 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0.03
Finally, IL-15-activated DCs themselves produce IL-2 in considerable quantities [30].
Gene_expression (produce) of IL-2
18) Confidence 0.77 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.27 Pain Relevance 0
IL-2 synthesis in PBMC cultures was induced by two different methods.
Gene_expression (synthesis) of IL-2 in PBMC
19) Confidence 0.77 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
The application of phorbol ester and calcium ionophore by-passes this requirement and mobilizes molecular mechanisms of IL-2 synthesis directly [25,26].
Gene_expression (synthesis) of IL-2
20) Confidence 0.77 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0

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