INT51160

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Context Info
Confidence 0.28
First Reported 1993
Last Reported 2001
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.55
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TAC1, Tacr1) signal transduction (Tacr1) extracellular space (TAC1)
extracellular region (TAC1) cytoplasm (Tacr1) signal transducer activity (Tacr1)
TAC1 (Homo sapiens)
Tacr1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 50 100.00 Very High Very High Very High
Neuropeptide 32 94.96 High High
Inflammation 15 93.68 High High
Pain 1 92.12 High High
antagonist 8 89.64 High High
Somatostatin 17 84.32 Quite High
qutenza 5 62.64 Quite High
cytokine 5 59.44 Quite High
Calcitonin gene-related peptide 15 5.00 Very Low Very Low Very Low
unmyelinated 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 3 93.68 High High
Pain 1 92.12 High High
INFLAMMATION 11 85.76 High High
Granuloma 2 76.56 Quite High
Hypersensitivity 2 44.60 Quite Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Sarcoidosis 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we identify epitopes on the NK1 receptor responsible for the specific binding of CP 96345 by systematic exchange of corresponding segments between the NK1 receptor and the homologous NK3 (neurokinin B) receptor, which does not bind the non-peptide ligand.
neurokinin Neg (not) Binding (bind) of NK1 receptor associated with substance p
1) Confidence 0.28 Published 1993 Journal Nature Section Abstract Doc Link 7681152 Disease Relevance 0.19 Pain Relevance 0.59
There are at least three distinct tachykinin receptors: neurokinin-1 receptor (NK-1R), NK-2R and NK-3R, which bind preferentially to SP, neurokinin A and neurokinin B, respectively [5].
neurokinin A Binding (bind) of neurokinin-1 receptor associated with substance p
2) Confidence 0.03 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.36 Pain Relevance 0.79

General Comments

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