INT51163

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 119
Total Number 121
Disease Relevance 67.48
Pain Relevance 49.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gal) Golgi apparatus (Gal) cytoplasm (Gal)
Anatomy Link Frequency
neurons 12
sciatic nerve 9
nerve 7
brain 6
dorsal root ganglia 6
Gal (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 401 100.00 Very High Very High Very High
Cholecystokinin 269 100.00 Very High Very High Very High
Neuropeptide 211 100.00 Very High Very High Very High
Enkephalin 40 100.00 Very High Very High Very High
Calcitonin gene-related peptide 15 100.00 Very High Very High Very High
Somatostatin 10 100.00 Very High Very High Very High
Peripheral nervous system 51 99.98 Very High Very High Very High
antagonist 73 99.96 Very High Very High Very High
allodynia 281 99.88 Very High Very High Very High
Neuropathic pain 240 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 629 100.00 Very High Very High Very High
Poisoning 52 100.00 Very High Very High Very High
Ganglion Cysts 100 99.92 Very High Very High Very High
Neuropathic Pain 596 99.88 Very High Very High Very High
Neurodegenerative Disease 7 99.84 Very High Very High Very High
Nervous System Injury 457 99.82 Very High Very High Very High
Injury 218 99.62 Very High Very High Very High
Nociception 203 99.58 Very High Very High Very High
Aging 10 99.58 Very High Very High Very High
Sprains And Strains 348 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Galanin expression is significantly up-regulated following damage to a peripheral nerve.
Gene_expression (expression) of Galanin in peripheral nerve
1) Confidence 0.78 Published 2001 Journal Neuroreport Section Abstract Doc Link 11711881 Disease Relevance 0.42 Pain Relevance 0.32
Galanin is a neuropeptide synthesized in many neuronal types including brainstem norepinephrine-producing cells of the locus coeruleus and the serotonin-producing neurons of the dorsal raphe nucleus.
Gene_expression (synthesized) of Galanin in neurons associated with medulla, locus ceruleus, neuropeptide, raphe and serotonin
2) Confidence 0.78 Published 2006 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 16611095 Disease Relevance 0.44 Pain Relevance 0.51
Immunohistochemical analysis showed that galanin is over-expressed both in small and large dorsal root ganglion cells in the transgene mouse, whereas large galanin-positive neurons were never seen in wild-type mice.
Gene_expression (expressed) of galanin in neurons associated with ganglion cysts and dorsal root ganglion
3) Confidence 0.78 Published 2004 Journal Brain Res. Section Abstract Doc Link 15464755 Disease Relevance 0.95 Pain Relevance 0.69
Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury.
Gene_expression (over) of Galanin in sciatic nerve associated with pain, nervous system injury, neuropathic pain and sciatic nerve
4) Confidence 0.78 Published 2004 Journal Brain Res. Section Title Doc Link 15464755 Disease Relevance 0.87 Pain Relevance 0.90
To further understand the functional role of galanin, a mouse overexpressing galanin under the platelet-derived growth factor-B was generated, and high levels of galanin expression were observed in several peripheral tissues and spinal cord.
Gene_expression (expression) of galanin in spinal cord associated with spinal cord
5) Confidence 0.77 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893631 Disease Relevance 0.19 Pain Relevance 0.13
Galanin overexpressing mice showed an attenuated plasma extravasation, an increased pain response in the formalin test, and changes in muscle physiology, but did not differ from wild type mice in sudomotor function.
Gene_expression (overexpressing) of Galanin in plasma associated with pain
6) Confidence 0.77 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893631 Disease Relevance 0.69 Pain Relevance 0.16
In transgenic superior cervical ganglia around half of all neuron profiles expressed galanin mRNA but axotomy did not cause a further increase, even if mRNA levels were increased in individual neurons.
Gene_expression (expressed) of galanin mRNA in neuron associated with targeted disruption
7) Confidence 0.77 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893631 Disease Relevance 0.46 Pain Relevance 0.13
In most parts of the peripheral nervous system galanin is expressed at very low levels.
Gene_expression (expressed) of galanin in peripheral nervous system associated with peripheral nervous system
8) Confidence 0.77 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893631 Disease Relevance 0.11 Pain Relevance 0.12
Aging by itself increased galanin expression in the superior cervical ganglion in wild type and transgenic mice, and in the latter also in preganglionic cholinergic neurons projecting to the superior cervical ganglion.
Gene_expression (expression) of galanin in superior cervical ganglion associated with targeted disruption, ganglion cysts and aging
9) Confidence 0.77 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893631 Disease Relevance 0.70 Pain Relevance 0.17
Galanin is a 29-amino-acid peptide expressed in dorsal root ganglion (DRG) neurones and spinal dorsal horn neurones.
Gene_expression (expressed) of Galanin in spinal associated with ganglion cysts, dorsal root ganglion and spinal dorsal horn
10) Confidence 0.77 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16487144 Disease Relevance 0.49 Pain Relevance 0.34
Genetically engineered mice, with either deletion or overexpression of galanin gene, showed altered resistance to seizures, which was in direct correlation with galanin gene expression.
Gene_expression (overexpression) of galanin gene associated with convulsion
11) Confidence 0.77 Published 2001 Journal Neuroscientist Section Abstract Doc Link 11765128 Disease Relevance 0.54 Pain Relevance 0.41
Genetically engineered mice, with either deletion or overexpression of galanin gene, showed altered resistance to seizures, which was in direct correlation with galanin gene expression.
Gene_expression (expression) of galanin gene associated with convulsion
12) Confidence 0.77 Published 2001 Journal Neuroscientist Section Abstract Doc Link 11765128 Disease Relevance 0.52 Pain Relevance 0.41
Galanin, a 29-amino-acid peptide expressed in dorsal root ganglia (DRG) and spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation.
Gene_expression (expressed) of Galanin in dorsal root ganglia associated with nervous system injury, inflammation and spinal dorsal horn
13) Confidence 0.76 Published 2002 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 12368071 Disease Relevance 0.40 Pain Relevance 0.27
Following the description of galanin expression increasing after nerve injury, the role of galanin in nociception and neuropathic pain has been the subject of a substantial body of research.
Gene_expression (expression) of galanin in nerve associated with nociception, nervous system injury and neuropathic pain
14) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 1.32 Pain Relevance 0.58
The level of galanin overexpression in the double heterozygous transgenic was assessed at the protein level by measuring the percentage of galanin positive neurons in the DRG one week after axotomy, both in the presence and absence of dox (Figure 2).
Gene_expression (overexpression) of galanin in neurons associated with targeted disruption
15) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 0.34 Pain Relevance 0.07
Galanin is expressed at low levels in ~5% of small diameter C-fibre neurons in the intact adult rodent dorsal root ganglia (DRG) [3-5].
Gene_expression (expressed) of Galanin in neurons associated with c fibre
16) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 0.38 Pain Relevance 0.57
This finding is consistent with the previously described galanin overexpressing mice, which used the same 20 kb and 4.6 kb constructs used in this study [22].
Gene_expression (overexpressing) of galanin
17) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 0.96 Pain Relevance 0.44
In order to direct galanin overexpression solely to galaninergic tissue, the previously characterised 20 kb galanin enhancer [21,24] was used to drive tetracycline controlled transactivator (tTA) expression (termed tTA transgene).
Gene_expression (overexpression) of galanin
18) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 0.71 Pain Relevance 0.32
A much smaller increase in galanin expression is observed in the dorsal horn after peripheral nerve injury [15] implying that much of the neuropeptide is anterogradely transported to the site of injury.
Gene_expression (expression) of galanin in dorsal horn associated with nervous system injury, injury, neuropeptide, dorsal horn and peripheral nerve injury
19) Confidence 0.76 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 1.18 Pain Relevance 0.67
The neuropeptide galanin is expressed developmentally in the DRG and is rapidly up-regulated 120-fold after peripheral nerve section in the adult.
Gene_expression (expressed) of galanin in peripheral nerve associated with neuropeptide
20) Confidence 0.75 Published 2001 Journal Curr Opin Pharmacol Section Abstract Doc Link 11712539 Disease Relevance 0.09 Pain Relevance 0.13

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