INT51164

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 6.30
Pain Relevance 7.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Galr1) plasma membrane (Galr1) signal transducer activity (Galr1)
Anatomy Link Frequency
brain 4
tail 2
hippocampus 1
Galr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 65 100.00 Very High Very High Very High
Neuropeptide 19 100.00 Very High Very High Very High
Locus ceruleus 24 99.68 Very High Very High Very High
c fibre 4 99.46 Very High Very High Very High
withdrawal 8 99.40 Very High Very High Very High
Hippocampus 88 99.36 Very High Very High Very High
opiate 12 98.96 Very High Very High Very High
Sciatic nerve 3 98.68 Very High Very High Very High
Neuropathic pain 4 97.32 Very High Very High Very High
addiction 4 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 48 99.08 Very High Very High Very High
Nervous System Injury 4 98.96 Very High Very High Very High
Injury 37 98.76 Very High Very High Very High
Nociception 9 98.24 Very High Very High Very High
Epilepsy 56 98.04 Very High Very High Very High
Neuropathic Pain 5 97.32 Very High Very High Very High
Status Epilepticus 28 97.28 Very High Very High Very High
Drug Dependence 4 97.00 Very High Very High Very High
Neurodegenerative Disease 8 96.68 Very High Very High Very High
Stress 1 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although GalR1 is the least abundantly expressed subtype in the hippocampus, it is most prominent in the highly vulnerable CA3 neurons.
Gene_expression (expressed) of GalR1 in hippocampus associated with hippocampus
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 0.91 Pain Relevance 0.26
Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB-dependent mechanism.
Gene_expression (expression) of Galanin receptor 1 gene
2) Confidence 0.78 Published 2001 Journal J. Neurochem. Section Title Doc Link 11145992 Disease Relevance 0 Pain Relevance 0.58
This study provides a molecular mechanism for the increased GalR1 expression in the LC seen following opiate withdrawal.
Gene_expression (expression) of GalR1 associated with locus ceruleus, opiate and withdrawal
3) Confidence 0.78 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11145992 Disease Relevance 0 Pain Relevance 0.52
Galanin acts at three G-protein-coupled receptors, galanin receptors (GalR1-3), each expressed in the DRGs as suggested by in situ hybridization and/or reverse transcriptase-polymerase chain reaction.
Gene_expression (expressed) of GalR1
4) Confidence 0.75 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16487144 Disease Relevance 0.50 Pain Relevance 0.34
On the other hand, mice lacking the GALR1 receptor (Galr1-/-) exhibited only slight increase in heat nociception in the hot plate, but not tail flick, test and showed no increase in spinal sensitization.
Neg (lacking) Gene_expression (lacking) of GALR1 in tail associated with nociception, spinal sensitization and tail-flick
5) Confidence 0.68 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15944013 Disease Relevance 0.95 Pain Relevance 0.56
On the other hand, mice lacking the GALR1 receptor (Galr1-/-) exhibited only slight increase in heat nociception in the hot plate, but not tail flick, test and showed no increase in spinal sensitization.
Neg (lacking) Gene_expression (lacking) of Galr1 in tail associated with nociception, spinal sensitization and tail-flick
6) Confidence 0.68 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15944013 Disease Relevance 0.95 Pain Relevance 0.56
A 2-µl Hamilton syringe with a 26-gauge needle mounted to an electrode holder containig the GalR1 antagonist, galantide (1 µM; Sigma Aldrich, St.
Gene_expression (antagonist) of GalR1 associated with antagonist
7) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 0 Pain Relevance 0.23
Thus, taken together our findings suggest that GalR1 deletion may contribute to hippocampal injury after kainate administration.
Gene_expression (deletion) of GalR1 associated with injury
8) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 1.17 Pain Relevance 0.03
This study was conducted to examine the excitability of the nociceptive flexor reflex and its sensitization by repetitive stimulation of C-fibers in anesthetized mice that lack the galanin-R1 receptor.
Neg (lack) Gene_expression (lack) of galanin-R1 receptor associated with nociception and c fibre
9) Confidence 0.67 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12842279 Disease Relevance 0.16 Pain Relevance 0.30
Overall, GalR1, GalR2, and GalR3 are distributed widely throughout the brain, correlate with widespread galanin binding, and colocalize with tyrosine hydroxylase in catecholaminergic brain areas.
Gene_expression (distributed) of GalR1 in brain
10) Confidence 0.67 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15514977 Disease Relevance 0.07 Pain Relevance 0.83
Although the distribution of GalR1, GalR2, and GalR3 largely recapitulates the pattern of galanin binding throughout the brain, some discrepancies exist, suggesting that another galanin receptor(s) may be present in some brain areas.
Gene_expression (distribution) of GalR1 in brain
11) Confidence 0.67 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15514977 Disease Relevance 0.08 Pain Relevance 0.94
The distribution of immunoreactivity for the three identified neuropeptide galanin receptors, GalR1, GalR2, and GalR3, was determined in areas of the mouse brain involved in drug addiction, including the ventral tegmental area (VTA), substantia nigra (SN), nucleus accumbens (NA), and locus coeruleus (LC).
Gene_expression (distribution) of GalR1 in brain associated with drug dependence, nucleus accumbens, ventral tegmentum, addiction, locus ceruleus, substantia nigra and neuropeptide
12) Confidence 0.67 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15514977 Disease Relevance 0.10 Pain Relevance 0.80
Although the distribution of GalR1, GalR2, and GalR3 largely recapitulates the pattern of galanin binding throughout the brain, some discrepancies exist, suggesting that another galanin receptor(s) may be present in some brain areas.
Gene_expression (present) of galanin receptor in brain
13) Confidence 0.67 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15514977 Disease Relevance 0.07 Pain Relevance 0.86
Our results suggest that a reduction of GalR1 expression in the C57BL/6J mouse strain renders them susceptible to excitotoxic injury following systemic kainate administration.
Gene_expression (expression) of GalR1 associated with injury and sprains and strains
14) Confidence 0.60 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001489 Disease Relevance 1.25 Pain Relevance 0.13
To study its physiological function, we recently synthesized a galanin-like galanin receptor antagonist, galantide.
Gene_expression (synthesized) of galanin receptor associated with antagonist
15) Confidence 0.31 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7681407 Disease Relevance 0.10 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox