INT51168

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Context Info
Confidence 0.80
First Reported 1993
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 7.66
Pain Relevance 9.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TACR1) cytoplasm (TACR1) signal transducer activity (TACR1)
Anatomy Link Frequency
plasma 1
blood vessels 1
nerves 1
ganglia 1
trachea 1
TACR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 110 100.00 Very High Very High Very High
antagonist 9 99.96 Very High Very High Very High
Spinal cord 2 99.64 Very High Very High Very High
substance P 40 99.40 Very High Very High Very High
Chronic pancreatitis 36 98.86 Very High Very High Very High
Pain 56 98.72 Very High Very High Very High
Osteoarthritis 2 98.40 Very High Very High Very High
Inflammation 37 97.88 Very High Very High Very High
Neurotransmitter 5 97.36 Very High Very High Very High
Migraine 4 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 98.88 Very High Very High Very High
Pancreatitis 36 98.86 Very High Very High Very High
Osteoarthritis 2 98.40 Very High Very High Very High
Pain 39 98.24 Very High Very High Very High
INFLAMMATION 38 97.88 Very High Very High Very High
Migraine Disorders 4 96.16 Very High Very High Very High
Nociception 3 95.76 Very High Very High Very High
Complex Regional Pain Syndromes 8 53.84 Quite High
Anaerobic Bacterial Infections 1 25.00 Low Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Localization of the neurokinin 1 receptor in hip joints of patients with painful osteoarthritis].
Localization (Localization) of neurokinin 1 receptor in hip joints associated with pain and osteoarthritis
1) Confidence 0.80 Published 2005 Journal Z Orthop Ihre Grenzgeb Section Title Doc Link 16118758 Disease Relevance 0.29 Pain Relevance 0.34
Following its release and NK1 receptor activation, dilatation and edema result, two events that are implicated in the pathogenesis of migraine headache.
Localization (release) of NK1 receptor associated with pressure and volume under development, migraine and headache
2) Confidence 0.69 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846424 Disease Relevance 0.36 Pain Relevance 0.85
NK-1 receptor mRNA was localized to submucosal glands.
Localization (localized) of NK-1 receptor mRNA in glands
3) Confidence 0.69 Published 1999 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10430743 Disease Relevance 0.35 Pain Relevance 0.32
In CP samples, in situ hybridization and immunohistochemistry localized NK-1R mRNA expression and protein mainly in the nerves, ganglia, blood vessels, inflammatory cells and occasionally in fibroblasts.
Localization (localized) of NK-1R mRNA in blood vessels associated with inflammation and chronic pancreatitis
4) Confidence 0.52 Published 2001 Journal Pain Section Abstract Doc Link 11275376 Disease Relevance 1.69 Pain Relevance 1.64
This study analyzed the expression and localization of neurokinin 1 receptor (NK-1R), which binds SP, and its association with pain and inflammation in CP.
Spec (analyzed) Localization (localization) of NK-1R associated with pain, inflammation, chronic pancreatitis and substance p
5) Confidence 0.49 Published 2001 Journal Pain Section Abstract Doc Link 11275376 Disease Relevance 1.16 Pain Relevance 1.23
In this case, over-expression of either Rab5a or its dominant negative variant did not affect receptor internalization per se but influenced the ability of the NK1R to translocate from superficial vesicles beneath the plasma membrane into intracellular endosomes.
Localization (translocate) of NK1R in plasma
6) Confidence 0.36 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.12
In CP samples, in situ hybridization and immunohistochemistry localized NK-1R mRNA expression and protein mainly in the nerves, ganglia, blood vessels, inflammatory cells and occasionally in fibroblasts.
Localization (localized) of NK-1R mRNA in nerves associated with inflammation and chronic pancreatitis
7) Confidence 0.18 Published 2001 Journal Pain Section Abstract Doc Link 11275376 Disease Relevance 1.69 Pain Relevance 1.64
In CP samples, in situ hybridization and immunohistochemistry localized NK-1R mRNA expression and protein mainly in the nerves, ganglia, blood vessels, inflammatory cells and occasionally in fibroblasts.
Localization (localized) of NK-1R mRNA in ganglia associated with inflammation and chronic pancreatitis
8) Confidence 0.18 Published 2001 Journal Pain Section Abstract Doc Link 11275376 Disease Relevance 1.69 Pain Relevance 1.64
Stimulation of IL-6 by SP occurred in a conventional receptor-mediated manner as demonstrated by its differential release by fragments SP 4-11 and SP 1-4 and by the blockage of IL-6 release with the non-peptide, NK-1 receptor antagonist, CP-99 994.
Localization (release) of NK-1 receptor associated with antagonist and substance p
9) Confidence 0.14 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657523 Disease Relevance 0.32 Pain Relevance 1.15
NK1Rs were localized in sections from the slices by using immunohistochemistry combined with fluorescence and confocal microscopy.
Localization (localized) of NK1Rs
10) Confidence 0.07 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9334388 Disease Relevance 0.09 Pain Relevance 0.74
The effects of synthetic tachykinin receptor agonists on mucus secretion by ferret trachea was determined in vitro in Ussing chambers using 35SO4 as a mucus marker and the synthetic peptides [Sar9,Met(O2)11]substance P (SarSP), [beta Ala8]neurokinin A-(4-10) and [MePhe7] neurokinin B which are selective for NK1, NK2 and NK3 tachykinin-receptors respectively.
Localization (secretion) of tachykinin receptor in trachea associated with agonist and substance p
11) Confidence 0.01 Published 1993 Journal Neuropeptides Section Abstract Doc Link 7681552 Disease Relevance 0 Pain Relevance 0.17

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