INT5117

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1985
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 118
Total Number 120
Disease Relevance 52.33
Pain Relevance 29.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T cell 53
lymphocytes 24
blood 12
natural killer cell 7
mononuclear cells 6
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1525 100.00 Very High Very High Very High
Inflammation 1080 100.00 Very High Very High Very High
aspirin 92 100.00 Very High Very High Very High
antagonist 182 99.98 Very High Very High Very High
agonist 112 99.98 Very High Very High Very High
Morphine 28 99.98 Very High Very High Very High
Intracerebroventricular 1 99.98 Very High Very High Very High
potassium channel 11 99.90 Very High Very High Very High
corticosteroid 131 99.84 Very High Very High Very High
narcan 17 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1192 100.00 Very High Very High Very High
Hyperplasia 66 100.00 Very High Very High Very High
Infection 224 99.92 Very High Very High Very High
Aging 432 99.76 Very High Very High Very High
Pruritus 33 99.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 362 99.48 Very High Very High Very High
Cancer 480 99.28 Very High Very High Very High
Eczema 79 99.28 Very High Very High Very High
Pressure And Volume Under Development 74 99.28 Very High Very High Very High
Head & Neck Cancer 20 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was some additive inhibition of IL-2 receptor expression at the higher concentrations of verapamil and cyclosporine that were tested.
Negative_regulation (inhibition) of Gene_expression (expression) of IL-2
1) Confidence 0.59 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.44 Pain Relevance 0.16
Production of IL-2 was suppressed by 0.1-100 microM of heroin, whereas exposure to methadone appeared to result in a generalized modulation, with suppression of IL-2 at most concentrations.
Negative_regulation (suppressed) of Gene_expression (Production) of IL-2 associated with methadone
2) Confidence 0.57 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7713351 Disease Relevance 0.12 Pain Relevance 0.45
Isolated compound inhibited the production of TNF-alpha and IL-2; further compound 5 showed significant analgesic activities in a dose dependant manner.
Negative_regulation (inhibited) of Gene_expression (production) of IL-2 associated with analgesic
3) Confidence 0.57 Published 2009 Journal Eur J Med Chem Section Abstract Doc Link 18243423 Disease Relevance 0.07 Pain Relevance 0.25
In addition, the production of IL-2 was inhibited by the opioid treatment, but this might not be the only mechanism of action.
Negative_regulation (inhibited) of Gene_expression (production) of IL-2 associated with opioid
4) Confidence 0.56 Published 2004 Journal Life Sci. Section Abstract Doc Link 15102522 Disease Relevance 0.08 Pain Relevance 0.52
Defective expression of IL-2 receptors on peripheral blood lymphocytes from patients with cluster headache.
Negative_regulation (Defective) of Gene_expression (expression) of IL-2 in lymphocytes associated with cluster headache
5) Confidence 0.55 Published 1990 Journal Headache Section Title Doc Link 2335478 Disease Relevance 0.35 Pain Relevance 0.35
In the 6 patients treated with MVP alone, depressed PHA reactivity was found pretherapy, which was augmented by indomethacin, but not by IL-2; this was associated with impaired production of IL-2.
Negative_regulation (impaired) of Gene_expression (production) of IL-2 associated with mitral valve prolapse
6) Confidence 0.50 Published 1987 Journal J Biol Response Mod Section Abstract Doc Link 3037033 Disease Relevance 0.75 Pain Relevance 0.07
In this regard, it is especially disappointing that IL-2 administration had no discernible effect, given the numerous studies, noted previously, that point to a defect in IL-2 production as one of the hallmarks of the immunodeficiency of chronic HIV infection.
Negative_regulation (defect) of Gene_expression (production) of IL-2 associated with acquired immune deficiency syndrome or hiv infection, infection and immunodeficiency
7) Confidence 0.48 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1783674 Disease Relevance 0.63 Pain Relevance 0.06
This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.
Negative_regulation (inhibition) of Gene_expression (production) of IL-2
8) Confidence 0.43 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.46 Pain Relevance 0.14
Routine flow cytometry (FACS) examination of cell surface markers ascertained that the numbers of IL-2 producing lymphocytes were comparable in all PBMC preparations.


Negative_regulation (numbers) of Gene_expression (producing) of IL-2 in lymphocytes
9) Confidence 0.43 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0.03
This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.
Negative_regulation (responsiveness) of Gene_expression (production) of IL-2
10) Confidence 0.43 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.46 Pain Relevance 0.14
This additive immunosuppression was not likely to have been related to these drugs' effects on interleukin-2 (IL-2) circuitry, since no additive inhibition of IL-2 production or IL-2 responsiveness was found.
Negative_regulation (inhibition) of Gene_expression (production) of IL-2
11) Confidence 0.43 Published 1991 Journal Am. J. Med. Section Abstract Doc Link 2039018 Disease Relevance 0.46 Pain Relevance 0.14
[Intracerebroventricular injection of interleukin-2 inhibits splenic sympathetic nerve activity].
Negative_regulation (inhibits) of Gene_expression (injection) of interleukin-2 in nerve associated with narcan and intracerebroventricular
12) Confidence 0.43 Published 1996 Journal Sheng Li Xue Bao Section Title Doc Link 9387781 Disease Relevance 0 Pain Relevance 0.34
Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone.
Negative_regulation (decreased) of Gene_expression (levels) of IL-2 associated with antagonist, narcan, opioid, infection and morphine
13) Confidence 0.40 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.38 Pain Relevance 1.00
This phenomenon led to an investigation of the phenotypic expression of PBL before and after IL-2 incubation, and of the IL-2 lymphocyte receptor.
Spec (investigation) Negative_regulation (investigation) of Gene_expression (expression) of IL-2 in lymphocyte
14) Confidence 0.40 Published 1990 Journal Headache Section Abstract Doc Link 2335478 Disease Relevance 0.32 Pain Relevance 0.32
The data support the hypothesis that cyclosporine may be an antagonist of calmodulin that selectively blocks early events in T lymphocyte activation leading to IL-2 synthesis, but does not inhibit the expression or function of the IL-2 receptor.
Negative_regulation (inhibit) of Gene_expression (expression) of IL-2 in T lymphocyte associated with antagonist
15) Confidence 0.40 Published 1986 Journal Transplantation Section Abstract Doc Link 3097893 Disease Relevance 0 Pain Relevance 0.12
Augmentation of IL-2 production by aspirin and/or TF5 was prevented by monocyte depletion of the PBL population.
Negative_regulation (prevented) of Gene_expression (production) of IL-2 in monocyte associated with aspirin
16) Confidence 0.40 Published 1985 Journal Immunopharmacology Section Abstract Doc Link 3926716 Disease Relevance 0.07 Pain Relevance 0.36
The synthetic peptide containing residues 43-49 of alpha-gliadin, the major protein component of gluten, has previously been shown to inhibit the production of lymphokine activities by mononuclear leukocytes.
Negative_regulation (inhibit) of Gene_expression (production) of lymphokine in leukocytes
17) Confidence 0.38 Published 1987 Journal Life Sci. Section Abstract Doc Link 3561149 Disease Relevance 0 Pain Relevance 0.11
Supporting this theory is the finding that ciclosporin A, an inhibitor of lymphokine production, reduces itch in atopic dermatitis.
Negative_regulation (inhibitor) of Gene_expression (production) of lymphokine associated with pruritus and eczema
18) Confidence 0.37 Published 1992 Journal Skin Pharmacol. Section Abstract Doc Link 1575979 Disease Relevance 1.69 Pain Relevance 0.44
In vitro tests included (a) phytohemagglutinin (PHA) responsiveness in the presence of indomethacin or interleukin-2 (IL-2), (b) natural killer cell (NK) function, and (c) PHA-induced IL-2 synthesis.
Negative_regulation (responsiveness) of Gene_expression (synthesis) of IL-2 in natural killer cell
19) Confidence 0.37 Published 1987 Journal J Biol Response Mod Section Abstract Doc Link 3037033 Disease Relevance 0.74 Pain Relevance 0.08
In vitro tests included (a) phytohemagglutinin (PHA) responsiveness in the presence of indomethacin or interleukin-2 (IL-2), (b) natural killer cell (NK) function, and (c) PHA-induced IL-2 synthesis.
Negative_regulation (responsiveness) of Gene_expression (synthesis) of IL-2 in natural killer cell
20) Confidence 0.37 Published 1987 Journal J Biol Response Mod Section Abstract Doc Link 3037033 Disease Relevance 0.74 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox