INT5118

Context Info Confidence 0.62 First Reported 1981 Last Reported 2010 Negated 10 Speculated 6 Reported most in Abstract Documents 97 Total Number 105 Disease Relevance 34.35 Pain Relevance 51.74

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)

Anatomy Link Frequency plasma 12 neurons 5 autonomic 3 gut 3 cerebrospinal fluid 2 SST (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 938 100.00 Serotonin 73 100.00 substance P 63 100.00 Neuropeptide 61 100.00 Enkephalin 58 100.00 agonist 52 100.00 antagonist 45 100.00 Pain 42 100.00 carbamazepine 29 100.00 narcan 28 100.00

Disease Link Frequency Relevance Heat Pain 35 100.00 Pancreatitis 8 100.00 Natriuresis 7 100.00 Attention Deficit Hyperactivity Disorder 131 99.92 Cancer 530 99.76 Increased Venous Pressure Under Development 28 99.56 Headache 29 99.52 Hyperglycemia 2 99.36 Nerve Root Compression 1 99.32 Disease 135 99.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The regulation of receptor expression as well as receptor internalization can give us insight into the effect of exogenous somatostatin on schistosomiasis-mediated intestinal pathology, as well as its modulation by intrinsically produced somatostatin levels.

Regulation (modulation) of somatostatin associated with somatostatin and schistosomiasis

1) Confidence 0.62 Published 2001 Journal Trop. Med. Int. Health Section Abstract Doc Link 11737838 Disease Relevance 0.70 Pain Relevance 0.40

Regulation of hypothalamic somatostatin by glucocorticoids.

Regulation (Regulation) of somatostatin associated with somatostatin

2) Confidence 0.60 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Title Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.16

There was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen.

Neg (no) Regulation (change) of somatostatin in plasma associated with somatostatin and cholecystokinin

3) Confidence 0.60 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6147213 Disease Relevance 0 Pain Relevance 0.19

The adrenergic system is involved in the neural control of GH secretion with both stimulatory and inhibitory influences mainly mediated via GHRH and/or somatostatin modulation.

Regulation (modulation) of somatostatin in neural associated with somatostatin

4) Confidence 0.60 Published 1990 Journal Endocrinol. Exp. Section Abstract Doc Link 1972919 Disease Relevance 0 Pain Relevance 0.57

Unlike heteromeric assembly of sst(2A) and sst(3), sst(2A)-MOR1 heterodimerization did not substantially alter the ligand binding or coupling properties of these receptors.

Neg (not) Regulation (ter t) of sst

5) Confidence 0.49 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.31

The aim of this study was to investigate the changes of SST-like immunoreactivity (SST-LI) in human serum before, immediately after and 2 h after surgical operations.

Spec (investigate) Regulation (changes) of SST associated with somatostatin

6) Confidence 0.45 Published 2008 Journal Neuroimmunomodulation Section Abstract Doc Link 18716415 Disease Relevance 0.19 Pain Relevance 0.50

The aim of this study was to investigate the changes of SST-like immunoreactivity (SST-LI) in human serum before, immediately after and 2 h after surgical operations.

Spec (investigate) Regulation (changes) of SST associated with somatostatin

7) Confidence 0.45 Published 2008 Journal Neuroimmunomodulation Section Abstract Doc Link 18716415 Disease Relevance 0.19 Pain Relevance 0.50

In this study the effects of somatostatin and octreotide on the basal short-circuit current and the cAMP- and Ca2+-stimulated short-circuit current were studied in isolated human colonic mucosa mounted in Ussing chambers.

Regulation (effects) of somatostatin associated with somatostatin

8) Confidence 0.45 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 11215722 Disease Relevance 0.09 Pain Relevance 0.26

Effect of somatostatin analog octreotide on human sphincter of Oddi.

Regulation (Effect) of somatostatin associated with somatostatin

9) Confidence 0.45 Published 1992 Journal Dig. Dis. Sci. Section Title Doc Link 1563323 Disease Relevance 0.09 Pain Relevance 0.23

The effect of the long-acting somatostatin analog octreotide on the sphincter of Oddi was investigated in seven subjects referred for endoscopic sphincter of Oddi manometry.

Regulation (effect) of somatostatin associated with somatostatin

10) Confidence 0.45 Published 1992 Journal Dig. Dis. Sci. Section Abstract Doc Link 1563323 Disease Relevance 0.09 Pain Relevance 0.21

Effect of somatostatin on 133Xe clearance from colonic mucosa before and after local nervous blockade in unanaesthetized man.

Regulation (Effect) of somatostatin associated with somatostatin

11) Confidence 0.45 Published 1986 Journal Scand. J. Gastroenterol. Section Title Doc Link 2877488 Disease Relevance 0 Pain Relevance 0.30

Several studies demonstrating a tight interaction between somatostatin and insulin indicate that insulin is another important factor in the regulation of basal and postprandial somatostatin release.

Regulation (regulation) of somatostatin associated with somatostatin

12) Confidence 0.44 Published 1983 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6138852 Disease Relevance 0.16 Pain Relevance 0.74

The role of somatostatin analogues in the treatment of refractory diarrhoea.

Regulation (role) of somatostatin associated with diarrhoea and somatostatin

13) Confidence 0.44 Published 1996 Journal Digestion Section Title Doc Link 8813486 Disease Relevance 1.39 Pain Relevance 0.10

The role of somatostatin analogues in the management of obstructive ileus in advanced cancer is discussed.

Regulation (role) of somatostatin associated with ileus, cancer and somatostatin

14) Confidence 0.44 Published 1993 Journal Support Care Cancer Section Abstract Doc Link 7511473 Disease Relevance 0.87 Pain Relevance 0.29

However, neuroleptics also alter the biochemical integrity of neurotensin, neuropeptide Y, substance P and somatostatin, which may also play a role in the overall expression of the neuroleptic-induced extrapyramidal reactions.

Regulation (alter) of somatostatin associated with somatostatin, neuropeptide and substance p

15) Confidence 0.44 Published 1988 Journal Neurosci Biobehav Rev Section Abstract Doc Link 2906420 Disease Relevance 0.47 Pain Relevance 0.78

Although much attention has been focused on the opioid peptides, substantial data strongly support the hypothesis that non-opioid peptides such as somatostatin, neurotensin and substance P are altered in a diverse number of neuropsychiatric disorders including Alzheimer's disease, Huntington's chorea, Parkinson's disease, major depression and schizophrenia.

Regulation (altered) of somatostatin associated with chorea, depression, somatostatin, disease, opioid, schizophrenia and substance p

16) Confidence 0.44 Published 1985 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 2934745 Disease Relevance 0.48 Pain Relevance 0.46

Double immunocytochemical methods demonstrated contacts of 5-HT fibers on enkephalin containing neurons of the spinal trigeminal nucleus and on somatostatin containing neurons of the medullary reticular formation.

Regulation (contacts) of somatostatin in neurons associated with somatostatin and enkephalin

17) Confidence 0.44 Published 1992 Journal Mol. Neurobiol. Section Abstract Doc Link 1285932 Disease Relevance 0 Pain Relevance 0.31

An analysis of changes in distribution of substance P, methionine-enkephalin, and somatostatin after simulated nerve root avulsion injury suggested a possible mechanism for deafferentation pain.

Regulation (changes) of somatostatin in nerve associated with nerve root compression, pain, injury, somatostatin, enkephalin, deafferentation and substance p

18) Confidence 0.44 Published 1984 Journal Neurosurgery Section Abstract Doc Link 6083504 Disease Relevance 0.39 Pain Relevance 0.63

[Analgesic effect of a somatostatin analog, SMS 201-995, on headache associated with tumor of the hypophysis].

Regulation (effect) of somatostatin in hypophysis associated with cancer, analgesic, somatostatin and headache

19) Confidence 0.44 Published 1989 Journal Med Clin (Barc) Section Title Doc Link 2622243 Disease Relevance 0.47 Pain Relevance 1.02

These protocols involve vasopressin antagonists, rapamycin and somatostatin at the present time.

Regulation (involve) of somatostatin associated with antagonist and somatostatin

20) Confidence 0.44 Published 2008 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 18619180 Disease Relevance 0.79 Pain Relevance 0.19

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