INT51190

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2001
Negated 0
Speculated 1
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0.41
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Htr3a) plasma membrane (Htr3a) cytoplasm (Htr3a)
Htr3a (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 4 100.00 Very High Very High Very High
lidocaine 3 99.50 Very High Very High Very High
Nicotine 4 99.48 Very High Very High Very High
cocaine 6 99.26 Very High Very High Very High
fluoxetine 3 98.56 Very High Very High Very High
Potency 2 97.14 Very High Very High Very High
substance P 1 84.00 Quite High
antagonist 2 83.52 Quite High
tetrodotoxin 2 79.80 Quite High
sodium channel 4 79.76 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 5 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rank order of potency for inhibition of veratridine-induced influx by local anaesthetics was tetracaine > bupivacaine > cocaine > lidocaine > procaine and that for inhibition of the 5-HT3 receptor channel was tetracaine > bupivacaine > cocaine > procaine > lidocaine.
Negative_regulation (inhibition) of 5-HT3 receptor associated with lidocaine, cocaine and potency
1) Confidence 0.58 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7682657 Disease Relevance 0.14 Pain Relevance 0.91
Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: potential involvement of sigma 2 binding sites.
Negative_regulation (Inhibition) of 5-HT3 associated with neuroblastoma
2) Confidence 0.57 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8878053 Disease Relevance 0.19 Pain Relevance 0.17
Inhibition of the serotonin 5-HT3 receptor by nicotine, cocaine, and fluoxetine investigated by rapid chemical kinetic techniques.
Spec (investigated) Negative_regulation (Inhibition) of 5-HT3 associated with nicotine, serotonin, fluoxetine and cocaine
3) Confidence 0.57 Published 2001 Journal Biochemistry Section Title Doc Link 11444989 Disease Relevance 0.08 Pain Relevance 0.70

General Comments

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