INT51198

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Context Info
Confidence 0.18
First Reported 1993
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.30
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRM1, PDYN) cell death (PDYN) extracellular region (PDYN)
Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) signal transducer activity (OPRM1)
Anatomy Link Frequency
putamen 2
OPRM1 (Homo sapiens)
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 8 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
Opioid receptor 1 3 100.00 Very High Very High Very High
Enkephalin 5 99.80 Very High Very High Very High
Opioid 1 97.36 Very High Very High Very High
Dopamine 1 96.56 Very High Very High Very High
cocaine 12 94.76 High High
Neuropeptide 1 93.76 High High
Morphine 2 81.04 Quite High
Nucleus accumbens 1 79.44 Quite High
Disease Link Frequency Relevance Heat
Death 1 86.68 High High
Cocaine Dependence 3 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The chimeric opiate receptor displays dramatically increased affinity for dynorphin peptides.
Positive_regulation (increased) of opiate receptor Binding (affinity) of dynorphin associated with dynorphin and opiate
1) Confidence 0.18 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 7929306 Disease Relevance 0 Pain Relevance 1.05
Marked reductions in the levels of enkephalin mRNA and mu opiate receptor binding were found in the caudate and putamen, concomitant with elevations in levels of dynorphin mRNA and kappa opiate receptor binding in the putamen and caudate, respectively.
Positive_regulation (elevations) of mu opiate receptor Binding (binding) of dynorphin mRNA in putamen associated with dynorphin, opioid receptor 1, opiate and enkephalin
2) Confidence 0.12 Published 1993 Journal Synapse Section Abstract Doc Link 7683144 Disease Relevance 0.30 Pain Relevance 1.03

General Comments

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