INT51201

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Context Info
Confidence 0.20
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) extracellular region (PENK) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) signal transducer activity (OPRM1)
Anatomy Link Frequency
putamen 2
OPRM1 (Homo sapiens)
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 3 100.00 Very High Very High Very High
Opioid receptor 1 1 100.00 Very High Very High Very High
Opioid 1 99.28 Very High Very High Very High
Dynorphin 2 96.76 Very High Very High Very High
cocaine 12 96.68 Very High Very High Very High
opiate 3 95.76 Very High Very High Very High
Neuropeptide 1 95.68 Very High Very High Very High
Dopamine 1 86.24 High High
Nucleus accumbens 1 69.12 Quite High
Disease Link Frequency Relevance Heat
Death 1 88.60 High High
Cocaine Dependence 3 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Marked reductions in the levels of enkephalin mRNA and mu opiate receptor binding were found in the caudate and putamen, concomitant with elevations in levels of dynorphin mRNA and kappa opiate receptor binding in the putamen and caudate, respectively.
Negative_regulation (reductions) of mu opiate receptor Binding (binding) of enkephalin mRNA in putamen associated with dynorphin, opioid receptor 1, opiate and enkephalin
1) Confidence 0.20 Published 1993 Journal Synapse Section Abstract Doc Link 7683144 Disease Relevance 0.23 Pain Relevance 0.98

General Comments

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