INT51202

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Context Info
Confidence 0.00
First Reported 1993
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.63
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1, PDYN) cell death (PDYN) extracellular region (PDYN)
signal transducer activity (OPRK1)
Anatomy Link Frequency
putamen 2
OPRK1 (Homo sapiens)
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 20 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
Kappa opioid receptor 1 100.00 Very High Very High Very High
Opioid receptor 1 3 98.70 Very High Very High Very High
Dopamine 1 96.56 Very High Very High Very High
Opioid 1 94.04 High High
Morphine 2 93.40 High High
cocaine 12 91.44 High High
Neuropeptide 1 90.44 High High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 1 95.44 Very High Very High Very High
INFLAMMATION 1 87.80 High High
Death 1 83.36 Quite High
Cancer 1 77.84 Quite High
Necrosis 1 77.36 Quite High
Cocaine Dependence 3 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, des-tyrosine leucine enkephalin (DTLE), an LE analogue that is missing the tyrosine residue required for binding to the kappa opioid receptor, was also neuroprotective (10(-15)-10(-13) M), as determined by DA uptake assay and TH ICC.
Positive_regulation (required) of kappa opioid receptor Spec (determined) Binding (binding) of leucine enkephalin associated with kappa opioid receptor and enkephalin
1) Confidence 0.00 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16179514 Disease Relevance 0.34 Pain Relevance 1.08
Marked reductions in the levels of enkephalin mRNA and mu opiate receptor binding were found in the caudate and putamen, concomitant with elevations in levels of dynorphin mRNA and kappa opiate receptor binding in the putamen and caudate, respectively.
Positive_regulation (elevations) of kappa opiate receptor Binding (binding) of dynorphin mRNA in putamen associated with dynorphin, opioid receptor 1, opiate and enkephalin
2) Confidence 0.12 Published 1993 Journal Synapse Section Abstract Doc Link 7683144 Disease Relevance 0.29 Pain Relevance 1.01
These data suggest that the putative second extracellular loop contributes substantially to the kappa receptor's selectivity in dynorphin ligand recognition.
Positive_regulation (contributes) of kappa receptor Binding (recognition) of dynorphin associated with dynorphin
3) Confidence 0.11 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 7929306 Disease Relevance 0 Pain Relevance 1.01

General Comments

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