INT51205

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Context Info
Confidence 0.00
First Reported 1993
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.01
Pain Relevance 7.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1, PDYN) cell death (PDYN) extracellular region (PDYN)
signal transducer activity (OPRK1)
Anatomy Link Frequency
putamen 1
OPRK1 (Homo sapiens)
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 30 100.00 Very High Very High Very High
Pain 29 100.00 Very High Very High Very High
Enkephalin 27 100.00 Very High Very High Very High
Kappa opioid receptor 27 100.00 Very High Very High Very High
Opioid 13 100.00 Very High Very High Very High
opiate 9 100.00 Very High Very High Very High
opioid receptor 7 100.00 Very High Very High Very High
agonist 1 100.00 Very High Very High Very High
orphanin 1 99.76 Very High Very High Very High
bradykinin 1 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 38 98.40 Very High Very High Very High
Drug Induced Neurotoxicity 1 95.44 Very High Very High Very High
Nociception 3 92.24 High High
INFLAMMATION 2 87.80 High High
Neuropathic Pain 1 85.08 High High
Death 2 82.40 Quite High
Conversion Disorder 1 81.52 Quite High
Repression 5 80.08 Quite High
Cancer 1 77.84 Quite High
Necrosis 1 77.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, des-tyrosine leucine enkephalin (DTLE), an LE analogue that is missing the tyrosine residue required for binding to the kappa opioid receptor, was also neuroprotective (10(-15)-10(-13) M), as determined by DA uptake assay and TH ICC.
kappa opioid receptor Spec (determined) Binding (binding) of leucine enkephalin associated with kappa opioid receptor and enkephalin
1) Confidence 0.00 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16179514 Disease Relevance 0.34 Pain Relevance 1.08
Marked reductions in the levels of enkephalin mRNA and mu opiate receptor binding were found in the caudate and putamen, concomitant with elevations in levels of dynorphin mRNA and kappa opiate receptor binding in the putamen and caudate, respectively.
kappa opiate receptor Binding (binding) of dynorphin mRNA in putamen associated with dynorphin, opioid receptor 1, opiate and enkephalin
2) Confidence 0.12 Published 1993 Journal Synapse Section Abstract Doc Link 7683144 Disease Relevance 0.29 Pain Relevance 1.01
Dynorphin interacts preferably with the kappa opioid receptor (KOR), which is part of the endogenous pain-relieving machinery [10].
kappa opioid receptor Binding (interacts) of Dynorphin associated with pain, dynorphin and kappa opioid receptor
3) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 1.30 Pain Relevance 1.22
These data suggest that the putative second extracellular loop contributes substantially to the kappa receptor's selectivity in dynorphin ligand recognition.
kappa receptor Binding (recognition) of dynorphin associated with dynorphin
4) Confidence 0.08 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 7929306 Disease Relevance 0 Pain Relevance 1.00
It is discussed that the helical region of the extracellular loop II of the kappa-opioid receptor may interact with the helical region of dynorphin with a high affinity in the membrane environments. beta-endorphin takes alpha-helical structure at N-terminus and the central regions and the rest of regions take unordered structure when the bind to the membrane.
kappa-opioid receptor Binding (interact) of dynorphin associated with dynorphin and kappa opioid receptor
5) Confidence 0.05 Published 2004 Journal Curr Top Med Chem Section Abstract Doc Link 14754381 Disease Relevance 0 Pain Relevance 0.78
Here, we characterized interactions of big dynorphin (Big Dyn), a 32-amino acid prodynorphin-derived peptide consisting of Dyn A and Dyn B, with human KOR, mu- (hMOR) and delta- (hDOR) opioid receptors and opioid receptor-like receptor 1 (hORL1) expressed in cells transfected with respective cDNA.
KOR Binding (interactions) of big dynorphin associated with dynorphin, kappa opioid receptor and opioid receptor
6) Confidence 0.02 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515546 Disease Relevance 0 Pain Relevance 0.68
Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor.
kappa-opioid receptor Binding (ligand) of Big dynorphin associated with pain, dynorphin and kappa opioid receptor
7) Confidence 0.02 Published 2006 Journal J. Neurochem. Section Title Doc Link 16515546 Disease Relevance 0 Pain Relevance 0.99
The kappa opioid receptor selective opioid peptide, dynorphin, recognized for its ability to produce dysphoria, is converted to the delta opioid receptor agonist Leu-enkephalin, with euphoric properties.
kappa opioid receptor Binding (recognized) of Leu-enkephalin associated with dynorphin, agonist, kappa opioid receptor, enkephalin, opioid receptor and opioid
8) Confidence 0.00 Published 2003 Journal Curr. Protein Pept. Sci. Section Abstract Doc Link 12570783 Disease Relevance 0.08 Pain Relevance 1.05

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