INT51206

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.92
Pain Relevance 7.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
spinal cord 2
striatum 2
amygdala 2
adult mouse 2
stomach smooth muscle 2
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 80 100.00 Very High Very High Very High
Pain 41 100.00 Very High Very High Very High
Neuropeptide 39 100.00 Very High Very High Very High
antagonist 28 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
calcitonin gene related peptide 11 100.00 Very High Very High Very High
amygdala 6 100.00 Very High Very High Very High
monoamine 2 100.00 Very High Very High Very High
Morphine 8 99.96 Very High Very High Very High
Spinal cord 14 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 9 99.84 Very High Very High Very High
Pain 49 99.44 Very High Very High Very High
Dementia 2 99.32 Very High Very High Very High
INFLAMMATION 39 99.28 Very High Very High Very High
Anxiety Disorder 4 99.16 Very High Very High Very High
Ganglion Cysts 101 98.88 Very High Very High Very High
Nociception 35 98.80 Very High Very High Very High
Vomiting 127 95.80 Very High Very High Very High
Neuropathic Pain 79 95.04 Very High Very High Very High
Targeted Disruption 54 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse.
Regulation (modulate) of Gene_expression (expressing) of Neurokinin-1 in amygdala associated with anxiety disorder, amygdala and morphine
1) Confidence 0.45 Published 2003 Journal J. Neurosci. Section Title Doc Link 12967989 Disease Relevance 0.23 Pain Relevance 0.87
In contrast, expression levels of mRNA for the Runx1-independent neuropeptides CGRP and Substance P/Tachykinin 1 (SP/Tac1) were little changed (Figure 3B), consistent with past results [16,17].
Neg (little) Regulation (changed) of Gene_expression (expression) of Tac1 associated with calcitonin gene related peptide, neuropeptide and substance p
2) Confidence 0.44 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.55 Pain Relevance 1.11
Immunohistochemistry demonstrated a consistent reduction of nNOS and NK2 receptor expression in mdx stomach smooth muscle cells and no change in nNOS and NK1 receptor expression in neurones.
Neg (no) Regulation (change) of Gene_expression (expression) of NK1 in stomach smooth muscle
3) Confidence 0.41 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16918764 Disease Relevance 0 Pain Relevance 0.31
Alternatively, up-regulation of NK1 receptor expression in the spinal cord [52] may counteract the threshold change.
Regulation (regulation) of Gene_expression (expression) of NK1 in spinal cord associated with spinal cord
4) Confidence 0.34 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.27 Pain Relevance 1.46
Effects on tachykinin gene expression
Regulation (Effects) of Gene_expression (expression) of tachykinin gene
5) Confidence 0.26 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
In addition, MK-801 (NMDA antagonist) decreased PPE message levels (DM 59 +/- 10%, DL 52 +/- 7%) without significantly altering PPT mRNA expression.
Neg (without) Regulation (altering) of Gene_expression (expression) of PPT mRNA associated with antagonist
6) Confidence 0.23 Published 2002 Journal Neuroreport Section Abstract Doc Link 11924893 Disease Relevance 0 Pain Relevance 0.45
Effects of L-DOPA on preproenkephalin and preprotachykinin gene expression in the MPTP-treated monkey striatum.
Regulation (Effects) of Gene_expression (expression) of preprotachykinin in striatum associated with parkinson's disease and enkephalin
7) Confidence 0.23 Published 1995 Journal Neuroscience Section Title Doc Link 8544992 Disease Relevance 0.47 Pain Relevance 0.42
The acute effects of the monoamine releaser p-chloroamphetamine (pCA, 10 mg/kg, i.p.) on preprotachykinin (PPT) and preproenkephalin (PPE) mRNA expression in the anterior (A-STR) vs. posterior (P-STR) striatum were studied in rodents at postnatal days (PND) 10, 21 and 35.
Regulation (effects) of in anterior Gene_expression (expression) of preprotachykinin in posterior associated with monoamine
8) Confidence 0.16 Published 1999 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9974171 Disease Relevance 0 Pain Relevance 0.15
Alterations in neurokinin 1 receptor gene expression in models of pain and inflammation.
Regulation (Alterations) of Gene_expression (expression) of neurokinin 1 associated with pain and inflammation
9) Confidence 0.14 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 8846421 Disease Relevance 0.95 Pain Relevance 0.72
Involvement of voltage-gated sodium channel Na(v)1.8 in the regulation of the release and synthesis of substance P in adult mouse dorsal root ganglion neurons.
Regulation (regulation) of Gene_expression (synthesis) of substance P in adult mouse associated with ganglion cysts, qutenza, root ganglion neuron, sodium channel and substance p
10) Confidence 0.13 Published 2008 Journal J. Pharmacol. Sci. Section Title Doc Link 18845912 Disease Relevance 0.99 Pain Relevance 0.94
Striosomal arrangement of met-enkephalin and substance P expression in parkinsonism-dementia complex on Guam.
Regulation (arrangement) of Gene_expression (expression) of substance P associated with parkinson's disease, dementia, enkephalin and substance p
11) Confidence 0.11 Published 1993 Journal Acta Neuropathol. Section Title Doc Link 7683167 Disease Relevance 0.38 Pain Relevance 0.64
Therefore, it can be proposed that NK1 receptor expression on immune cells such as mast cells is influenced by environmental inflammatory factors such as cytokines.
Regulation (influenced) of Gene_expression (expression) of NK1 in mast cells associated with inflammation and cytokine
12) Confidence 0.05 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.22 Pain Relevance 0.47
Palonosetron + neurokinin-1 antagonists
Regulation (Palonosetron) of Gene_expression (antagonists) of neurokinin-1 associated with antagonist
13) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387285 Disease Relevance 0.86 Pain Relevance 0.20

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