INT51232

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Context Info
Confidence 0.31
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.32
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CSH1) extracellular region (CSH1)
Anatomy Link Frequency
cytotrophoblast 2
CSH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 4 99.98 Very High Very High Very High
narcan 3 96.44 Very High Very High Very High
Glutamate receptor 4 70.96 Quite High
antagonist 2 32.32 Quite Low
Enkephalin 3 25.00 Low Low
agonist 3 25.00 Low Low
Analgesic 1 25.00 Low Low
opiate 1 25.00 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 1 76.92 Quite High
Cockayne Syndrome 110 62.48 Quite High
Neurodegenerative Disease 2 60.80 Quite High
Contagious Ecthyma 12 32.48 Quite Low
Bordatella Infection 1 25.00 Low Low
Repression 2 24.36 Low Low
Hutchinson-gilford Progeria Syndrome 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low
Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously reported that kappa opioids stimulated the release of human placental lactogen (hPL) from trophoblastic cells and that this effect was prevented by co-incubation with naloxone.
Positive_regulation (stimulated) of Localization (release) of placental lactogen associated with narcan and opioid
1) Confidence 0.31 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7684340 Disease Relevance 0 Pain Relevance 0.30
Just as striking was the association of MER85 elements with genes that are repressed following UV irradiation (Tables S5 and S6); UV is known to cause nuclear translocation of CSA [75] which may in turn be required for full CSB function.
Positive_regulation (cause) of Localization (translocation) of CSA
2) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.12 Pain Relevance 0.03
Thus at 4–5 weeks EGF stimulates cytotrophoblast cell proliferation, whereas at 6–12 weeks it stimulates secretion of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) into the supernatant [19].
Positive_regulation (stimulates) of Localization (secretion) of placental lactogen in cytotrophoblast
3) Confidence 0.19 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.08 Pain Relevance 0
Just as striking was the association of MER85 elements with genes that are repressed following UV irradiation (Tables S5 and S6); UV is known to cause nuclear translocation of CSA [75] which may in turn be required for full CSB function.
Positive_regulation (required) of Localization (translocation) of CSA
4) Confidence 0.18 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2268245 Disease Relevance 0.12 Pain Relevance 0.04

General Comments

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