INT51243

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Context Info
Confidence 0.33
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.52
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod)
plasma membrane (Umod)
Anatomy Link Frequency
urine 2
tubules 1
Umod (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 73.64 Quite High
antagonist 1 64.40 Quite High
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Neuropathic pain 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
hypoalgesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 8 89.04 High High
Fabry Disease 36 5.00 Very Low Very Low Very Low
Disease 22 5.00 Very Low Very Low Very Low
Gauchers Disease 14 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Peripheral Neuropathy 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Cerebrovascular Disease 4 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Combined ERT and SRT is most effective at reducing uromodulin levels in the urine of Fabry-Rag mice
Negative_regulation (reducing) of uromodulin in urine
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Figure 5 shows that although monotherapy by SRT and ERT had some ability to decrease urine uromodulin concentrations (20–25% reduction compared to untreated), combining ERT and SRT appeared to result in an additive effect, reducing uromodulin concentrations by at least 50%.
Negative_regulation (reducing) of uromodulin in urine
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Tamm-Horsfall protein, a glycoprotein synthesized by the distal tubules, decreased significantly less in the verapamil group compared to the controls.
Negative_regulation (decreased) of Tamm-Horsfall protein in tubules
3) Confidence 0.28 Published 1993 Journal J. Urol. Section Abstract Doc Link 7685425 Disease Relevance 0.31 Pain Relevance 0.07
After ESWL there was a significant increase in urinary beta 2-microglobulin and albumin (p < 0.001), and the urinary Tamm-Horsfall protein decreased significantly (p < 0.01) compared with before ESWL in group 1.
Negative_regulation (decreased) of Tamm-Horsfall protein
4) Confidence 0.10 Published 1995 Journal J. Urol. Section Abstract Doc Link 7861490 Disease Relevance 0.22 Pain Relevance 0.11

General Comments

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