INT51244

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Context Info
Confidence 0.60
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 14
Disease Relevance 2.03
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod)
plasma membrane (Umod)
Anatomy Link Frequency
urine 7
macrophages 2
THP-1 1
brain 1
tubules 1
Umod (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 60 98.90 Very High Very High Very High
interstitial cystitis 2 98.72 Very High Very High Very High
Inflammation 117 98.70 Very High Very High Very High
anesthesia 12 73.64 Quite High
Dismenorea 1 46.00 Quite Low
Spinal cord 16 38.16 Quite Low
Peripheral nervous system 16 23.72 Low Low
Neuropathic pain 16 12.00 Low Low
peripheral neuropathy 24 8.52 Low Low
tolerance 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 2 98.72 Very High Very High Very High
INFLAMMATION 123 98.70 Very High Very High Very High
Glioma 2 93.92 High High
Affective Disorder 1 92.80 High High
Disease Progression 16 87.28 High High
Shock 4 86.40 High High
Gauchers Disease 56 81.60 Quite High
Mental Disorders 2 75.00 Quite High
Fabry Disease 144 73.52 Quite High
Diabetes Mellitus 87 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased urinary levels of Tamm-Horsfall glycoprotein suggest a systemic etiology of interstitial cystitis.
Gene_expression (levels) of Tamm-Horsfall glycoprotein associated with interstitial cystitis
1) Confidence 0.60 Published 1996 Journal J. Urol. Section Title Doc Link 8709369 Disease Relevance 0.10 Pain Relevance 0.19
Uromodulin expression and processing appears to be abnormal in Fabry patients [32].
Gene_expression (expression) of Uromodulin
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Combined ERT and SRT is most effective at reducing uromodulin levels in the urine of Fabry-Rag mice
Gene_expression (levels) of uromodulin in urine
3) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
When comparing ERT alone to the ERT every two months plus SRT, significant improvements were also observed in urine uromodulin levels (Figure 5), loss of heat-sensitivity (Figure 6) and prevention of DRG cell vacuolation (Figure 7).
Gene_expression (comparing) of uromodulin in urine
4) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.17 Pain Relevance 0
Taking into account the effects of combination ERT and SRT on urine volume (data not shown; see Figure 2), total uromodulin amounts excreted over a 24 h period were most effectively reduced by the combined ERT and SRT approaches (?
Gene_expression (amounts) of uromodulin in urine
5) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
In some assays, notably kidney and urine GL-3 levels (Figure 4), urine uromodulin level (Figure 5), heat-sensitivity (Figure 6) and degree of DRG vacuolation (Figure 7), this therapeutic option was as, or more effective than, ERT every two months alone.
Gene_expression (level) of uromodulin in urine
6) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.30 Pain Relevance 0
Characterization of the Fabry-Rag mouse showed that urine uromodulin levels were significantly elevated.
Gene_expression (levels) of uromodulin in urine
7) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Quantitation of urine uromodulin
Gene_expression (Quantitation) of uromodulin in urine
8) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Tamm-Horsfall protein, a glycoprotein synthesized by the distal tubules, decreased significantly less in the verapamil group compared to the controls.
Gene_expression (synthesized) of Tamm-Horsfall protein in tubules
9) Confidence 0.50 Published 1993 Journal J. Urol. Section Abstract Doc Link 7685425 Disease Relevance 0.30 Pain Relevance 0.07
A sandwich ELISA was developed using commercially available reagents to quantitate uromodulin levels in the urine.
Gene_expression (levels) of uromodulin in urine
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
The aim of the present study was to evaluate the synthesis of dihydroprogesterone (DHP), tetrahydroprogesterone (THP), and the activity of 5alpha-reductase (5alphaR) which regulates the reduction of P to DHP on exposure to supraphysiological levels of E2 in vitro (C6 glioma cells) and in vivo (mouse brain).
Gene_expression (synthesis) of THP in brain associated with glioma
11) Confidence 0.45 Published 2004 Journal Brain Res. Section Abstract Doc Link 15312799 Disease Relevance 0.34 Pain Relevance 0
Two macrophage cell systems, human THP-1 macrophages and mouse RAW-Blue macrophages, were employed in the high-throughput screening platform to determine the effects of the active fractions.
Gene_expression (macrophages) of THP-1 in macrophages
12) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.38 Pain Relevance 0.35
Conditioned THP-1 medium was collected after Rx (5 ?
Gene_expression (medium) of THP-1 in THP-1
13) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.07 Pain Relevance 0
Treatment with the selected active fraction Rx caused a drastic reduction in secretion of pro-inflammatory cytokines including MCP-1 and IL-6 in the conditioned medium of THP-1 macrophages, in a dose-dependent manner (figure 3a, b).
Gene_expression (macrophages) of THP-1 in macrophages associated with inflammation and cytokine
14) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 0.38 Pain Relevance 0.34

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