INT51253

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Context Info
Confidence 0.60
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.43
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hspa4) lipid particle (Hspa4) nucleolus (Hspa4)
nucleus (Hspa4) cytoplasm (Hspa4)
Anatomy Link Frequency
sciatic nerve 1
motor neurons 1
Hspa4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 4 99.28 Very High Very High Very High
Sciatic nerve 8 96.32 Very High Very High Very High
unmyelinated 4 94.40 High High
peripheral neuropathy 8 89.40 High High
Nerve growth factor 4 80.32 Quite High
Calcitonin gene-related peptide 4 70.16 Quite High
Disease Link Frequency Relevance Heat
Shock 8 100.00 Very High Very High Very High
Stress 4 99.32 Very High Very High Very High
Neuropathic Pain 12 99.28 Very High Very High Very High
Peripheral Neuropathy 8 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hsp 70 and ubiquitin are proteins involved in protein metabolism and their expression is regulated during cellular stress.
Regulation (regulated) of Hsp 70 associated with stress
1) Confidence 0.60 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 7685508 Disease Relevance 0.66 Pain Relevance 0.32
Opposite effects of axon damage on heat shock proteins (hsp 70) and ubiquitin contents in motor neurons of neuropathic rats.
Regulation (effects) of hsp 70 in motor neurons associated with neuropathic pain and shock
2) Confidence 0.60 Published 1993 Journal Neurosci. Lett. Section Title Doc Link 7685508 Disease Relevance 0.65 Pain Relevance 0.29
Motoneurone staining for hsp 70 and ubiquitin were differentially altered at the peak of the neuropathy.
Regulation (altered) of hsp 70 associated with neuropathic pain
3) Confidence 0.44 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 7685508 Disease Relevance 0.66 Pain Relevance 0.35
Alteration in the motoneurone contents of heat shock protein (hsp 70) and ubiquitin were studied in rats which had been subject to loose ligation of one common sciatic nerve.
Regulation (Alteration) of hsp 70 in sciatic nerve associated with shock and sciatic nerve
4) Confidence 0.26 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 7685508 Disease Relevance 0.46 Pain Relevance 0.20

General Comments

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