INT51259

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Context Info
Confidence 0.05
First Reported 1993
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 5.63
Pain Relevance 9.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Zbtb38) nucleus (Zbtb38) intracellular (Zbtb38)
DNA binding (Zbtb38)
Anatomy Link Frequency
neurons 9
IB4 3
horn 2
sensory neurons 1
peptidergic neurons 1
Zbtb38 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1154 99.98 Very High Very High Very High
trigeminal ganglion 774 99.98 Very High Very High Very High
opioid receptor 15 99.98 Very High Very High Very High
Nerve growth factor 1204 99.72 Very High Very High Very High
parabrachial 3 99.52 Very High Very High Very High
nociceptor 73 99.46 Very High Very High Very High
dorsal root ganglion 147 97.76 Very High Very High Very High
qutenza 624 97.44 Very High Very High Very High
Neuropeptide 143 96.32 Very High Very High Very High
Somatostatin 6 93.72 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 945 99.98 Very High Very High Very High
Injury 286 99.80 Very High Very High Very High
Nociception 101 96.08 Very High Very High Very High
Depression 23 90.00 High High
INFLAMMATION 60 78.96 Quite High
Apoptosis 24 60.52 Quite High
Vibrio Infection 1 55.96 Quite High
Pain 46 52.64 Quite High
Hyperalgesia 84 51.52 Quite High
Congenital Anomalies 2 42.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most of the neurons expressing the injury-induced peptides appeared large, presumably alpha-motoneurons but there were also many small neurons expressing galanin in the ventral horn ipsilateral to lesion.
Gene_expression (expressing) of neurons in horn associated with injury
1) Confidence 0.05 Published 1993 Journal Exp Brain Res Section Abstract Doc Link 7686109 Disease Relevance 0.18 Pain Relevance 0.44
Most of the neurons expressing the injury-induced peptides appeared large, presumably alpha-motoneurons but there were also many small neurons expressing galanin in the ventral horn ipsilateral to lesion.
Gene_expression (expressing) of neurons in horn associated with injury
2) Confidence 0.05 Published 1993 Journal Exp Brain Res Section Abstract Doc Link 7686109 Disease Relevance 0.17 Pain Relevance 0.43
Preprocholecystokinin mRNA-expressing neurons in the rat parabrachial nucleus: subnuclear localization, efferent projection, and expression of nociceptive-related intracellular signaling substances.
Gene_expression (expressing) of neurons in parabrachial nucleus associated with nociception, nociceptor and parabrachial
3) Confidence 0.03 Published 1998 Journal J. Comp. Neurol. Section Title Doc Link 9766403 Disease Relevance 0.27 Pain Relevance 0.31
TG neurons express two distinct classes of K+ currents at varying levels, involving the IK and IA currents [63,64].
Gene_expression (express) of neurons in neurons associated with trigeminal ganglion
4) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.65 Pain Relevance 0.80
-opioid receptor expressing rhythmogenic preBötC neurons [32].
Gene_expression (expressing) of neurons in neurons associated with opioid receptor
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0.18 Pain Relevance 0.50
For colocalization studies, the previously generated NF-H-immunoreactive neuron counts for each well were followed by counting of CGRP- or TRPV1-immunoreactive or IB4-binding neurons in the same wells to generate the proportion of neurons expressing these markers.
Gene_expression (expressing) of neurons in IB4 associated with calcitonin gene-related peptide
6) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.14 Pain Relevance 0.16
This likely indicates that the culturing process conditions are either selectively preserving peptidergic neurons or that normally non-peptidergic neurons novelly express CGRP in culture.
Gene_expression (express) of neurons in peptidergic neurons associated with calcitonin gene-related peptide
7) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.46 Pain Relevance 0.53
GDNF receptors are more widespread, with as many as 60% of dorsal root ganglion (DRG) neurons containing c-ret, while GFR components are found throughout the c-ret population, as well as in c-ret negative neurons [8,9].
Neg (negative) Gene_expression (negative) of neurons in neurons associated with ganglion cysts and dorsal root ganglion
8) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.60 Pain Relevance 0.82
At least 500 NF-H-immunoreactive neurons were counted under every growth factor condition to calculate proportions of neurons expressing the three markers examined.
Gene_expression (expressing) of neurons in neurons
9) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.22 Pain Relevance 0.20
To determine to what extent the enhancement of CAP-evoked CGRP release in response to growth factor treatment might derive from increased neuronal survival and/or up-regulation in the proportion of neurons expressing TRPV1, release data were normalized to the number of TRPV1-immunoreactive neurons (Fig. 8B; TRPV1 neuron proportions shown in Table 1).
Gene_expression (expressing) of neurons in neuron associated with qutenza and calcitonin gene-related peptide
10) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0 Pain Relevance 1.52
We then utilized the proportion of CGRP-expressing neurons under NGF, GDNF or BDNF treatment conditions to normalize K+- evoked CGRP release to the number of CGRP-immunoreactive neurons under each condition, respectively (see Methods for normalization calculation).
Gene_expression (expressing) of neurons in neurons associated with nerve growth factor and calcitonin gene-related peptide
11) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.06 Pain Relevance 0.81
After normalization to the number of neurons that express TRPV1 and CGRP, we found that NGF had a much greater effect on CAP-evoked CGRP release and neuropeptide content, on a per cell basis, than did GDNF.
Gene_expression (express) of neurons in neurons associated with qutenza, nerve growth factor, neuropeptide and calcitonin gene-related peptide
12) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.33 Pain Relevance 0.90
The proportions of TG neurons in culture that expressed CGRP- or TRPV1-immunoreactivity or IB4-binding sites were assessed with attention to how these proportions changed in the presence of NGF, GDNF and BDNF.
Gene_expression (expressed) of neurons in IB4 associated with nerve growth factor, trigeminal ganglion and calcitonin gene-related peptide
13) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.43 Pain Relevance 0.48
This was defined by scaling the image, using Metamorph's built-in scaling feature, to an average pixel value for negative neurons in the case of TRPV1, CGRP and IB4 (no scaling was performed for NF-H ICC) and establishing all neurons as positive that were above that threshold.
Neg (negative) Gene_expression (negative) of neurons in IB4 associated with calcitonin gene-related peptide
14) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.07 Pain Relevance 0.15
We observed that a greater proportion of TRPV1-immunoreactive neurons were present with GDNF supplementation (nearly 30% increase), again indicating either that GDNF preferentially supports the survival of TRPV1-expressing sensory neurons or that neurons that do not normally express TRPV1 begin expressing TRPV1 when GDNF is included in the culture medium.
Neg (not) Gene_expression (express) of neurons in neurons
15) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.74 Pain Relevance 0.49
We observed that a greater proportion of TRPV1-immunoreactive neurons were present with GDNF supplementation (nearly 30% increase), again indicating either that GDNF preferentially supports the survival of TRPV1-expressing sensory neurons or that neurons that do not normally express TRPV1 begin expressing TRPV1 when GDNF is included in the culture medium.
Neg (not) Gene_expression (express) of neurons in neurons
16) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.73 Pain Relevance 0.49
Notably, the proportion of sensory neurons in vitro that expressed CGRP (~65%) was much larger than the known proportion of CGRP-containing neurons in native TG (~35%, [57]).
Gene_expression (expressed) of neurons in sensory neurons associated with trigeminal ganglion and calcitonin gene-related peptide
17) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.39 Pain Relevance 0.47

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