INT5126

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Context Info
Confidence 0.48
First Reported 1981
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 2.12
Pain Relevance 5.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
follicles 2
gonadotroph 2
pituitary 2
body 2
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 30 100.00 Very High Very High Very High
Clonidine 2 100.00 Very High Very High Very High
narcan 46 99.98 Very High Very High Very High
Morphine 14 98.16 Very High Very High Very High
Endogenous opioid 11 86.08 High High
antagonist 9 83.28 Quite High
opiate 4 80.44 Quite High
withdrawal 2 59.08 Quite High
agonist 1 25.00 Low Low
imagery 3 16.00 Low Low
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 11 100.00 Very High Very High Very High
Galactorrhea 1 95.00 High High
Growth Problems 1 94.24 High High
Rheumatic Heart Disease 13 86.52 High High
Ovarian Cysts 36 82.44 Quite High
Reprotox - General 2 3 77.80 Quite High
Aging 1 75.00 Quite High
Mitral Valve Stenosis 1 71.84 Quite High
Aortic Valve Insufficiency 1 70.64 Quite High
Cyst 12 69.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: To investigate whether enhanced LH levels of women with polycystic ovarian syndrome (PCOS) are the consequence of an absent hypothalamic opioid inhibitory control and/or an increased sensitivity of gonadotroph to GnRH, induced by sensitizing effects of circulating opioid peptides.
Spec (whether) Positive_regulation (induced) of Spec (whether) Positive_regulation (enhanced) of LH in gonadotroph associated with polycystic ovary syndrome and opioid
1) Confidence 0.48 Published 1994 Journal Fertil. Steril. Section Abstract Doc Link 8034071 Disease Relevance 0.28 Pain Relevance 0.27
RESULTS: In comparison with normal cycling women, PCOS showed normal frequency and increased amplitude LH pulses, elevated mean LH levels, and increased LH response to GnRH.
Positive_regulation (increased) of Positive_regulation (response) of LH
2) Confidence 0.48 Published 1994 Journal Fertil. Steril. Section Body Doc Link 8034071 Disease Relevance 0 Pain Relevance 0
The same occurred after naltrexone treatment, when significant increases in both mean LH levels (P < 0.02) and LH response to GnRH (P < 0.025) were observed.
Positive_regulation (increases) of Positive_regulation (response) of LH
3) Confidence 0.48 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0.06 Pain Relevance 0.34
The same occurred after naltrexone treatment, when significant increases in both mean LH levels (P < 0.02) and LH response to GnRH (P < 0.025) were observed.
Positive_regulation (increases) of Positive_regulation (increases) of LH response
4) Confidence 0.48 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0.06 Pain Relevance 0.34
Chronic opioid blockade in bromocriptine-treated non-lactating women did not result in increased LH levels.
Neg (not) Positive_regulation (result) of Neg (not) Positive_regulation (increased) of LH associated with opioid
5) Confidence 0.46 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1899421 Disease Relevance 0 Pain Relevance 0.31
Naltrexone administration (40 mg at 0630 and 2200 h the day before blood sampling and at 0630 h, 30 min before starting frequent blood sampling at 10-min intervals for 12 h) to young men (n = 8) induced a significant increase in individual mean baseline plasma LH levels, LH pulse frequency, and the sum of LH pulse amplitudes.
Positive_regulation (induced) of Positive_regulation (increase) of LH in plasma
6) Confidence 0.45 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2909555 Disease Relevance 0.07 Pain Relevance 0.15
However, increases in LH pulse frequency were also induced by naloxone treatment at a postpubertal age in estradiol-treated OVX sheep, indicating that opioid inhibition is still present at a time when sensitivity to the feedback effects of ovarian steroids is markedly reduced and endogenous LH secretion is increased.
Positive_regulation (induced) of Positive_regulation (increases) of LH associated with narcan and opioid
7) Confidence 0.40 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.67
The rise of LH correlated with the mean basal LH concentrations; a low basal level only responded to naloxone with a small increase in circulating LH concentration and vice versa.
Positive_regulation (increase) of Positive_regulation (circulating) of LH associated with narcan
8) Confidence 0.36 Published 1981 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6785301 Disease Relevance 0.10 Pain Relevance 0.43
Plasma basal concentrations of LH and FSH were low and and did not increase after GnRH stimulation test, while the estradiol level was <37 pmol/l.
Neg (not) Positive_regulation (increase) of Positive_regulation (concentrations) of LH in Plasma
9) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892512 Disease Relevance 0.63 Pain Relevance 0
Acute administration of an antiopoid (Naloxone), 2 mg i.v. both in young and elderly men at rest showed that in young and elderly men, Naloxone induced a comparable increase of LH levels.
Positive_regulation (induced) of Positive_regulation (increase) of LH associated with narcan
10) Confidence 0.31 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2913408 Disease Relevance 0 Pain Relevance 0.27
Administration of the opioid blocker induced a significant increase in serum LH concentrations only in those patients in ideal body weight and amenorrhoea who resumed ovulatory cycles within the 6 months following the last study as well as in patients with an ideal body weight and ovulatory cycles and in normal controls.
Positive_regulation (induced) of Positive_regulation (increase) of LH in body
11) Confidence 0.22 Published 1992 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 1286522 Disease Relevance 0 Pain Relevance 0
When naloxone and ANG II were given together stimulated LH increase was greatly enhanced.
Positive_regulation (enhanced) of Positive_regulation (increase) of LH associated with narcan
12) Confidence 0.20 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 8059012 Disease Relevance 0 Pain Relevance 0.58
While the 24-h naloxone infusions did not alter any of the pulse characteristics in the EFP, they elicited a robust increase in LH pulsatile activity in the LFP, composed of a progressive rise in LH pulse amplitudes and transverse mean levels.
Positive_regulation (elicited) of Positive_regulation (increase) of LH associated with narcan
13) Confidence 0.17 Published 1989 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2745936 Disease Relevance 0 Pain Relevance 0.29
The large antral follicles of wave 2 of the cycle, that were exposed to the GnRH induced increase in LH pulse frequency, grew to a larger size than the equivalent follicles in the control ewes or even the follicles in wave 1 of GnRH treated ewes.
Positive_regulation (induced) of Positive_regulation (increase) of LH in follicles
14) Confidence 0.12 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2731046 Disease Relevance 0 Pain Relevance 0
LHRH provoked an increase in plasma LH concentration in control as well as in treated animals but the amplitude of the net peak height increased progressively up to the third pulse in NAL treated animals, while there was no increase in pituitary responsiveness to LHRH in control prepubertal ewes.
Positive_regulation (increased) of Positive_regulation (increase) of LH in pituitary
15) Confidence 0.12 Published 1989 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 2508375 Disease Relevance 0 Pain Relevance 0.18
Injection of GnRH induced 400 and 50% increases in LH and FSH respectively.
Positive_regulation (induced) of Positive_regulation (increases) of LH
16) Confidence 0.06 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3146613 Disease Relevance 0 Pain Relevance 1.29
Growth hormone (GH) response to clonidine provocation, LH and FSH response to LHRH stimulation, and in boys testosterone (T) response to HCG were evaluated.
Positive_regulation (response) of Positive_regulation (response) of LH associated with clonidine
17) Confidence 0.04 Published 1997 Journal J. Trop. Pediatr. Section Abstract Doc Link 9078821 Disease Relevance 0.92 Pain Relevance 0.10

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