INT51262

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.31
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TKT) small molecule metabolic process (TKT) nucleolus (TKT)
peroxisome (TKT) nucleus (TKT) carbohydrate metabolic process (TKT)
Anatomy Link Frequency
erythrocyte 1
Neuron 1
Gill 1
TKT (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 92.48 High High
imagery 28 91.36 High High
alcohol 1 87.36 High High
aspirin 7 86.80 High High
Pain 18 81.96 Quite High
abdominal pain 2 77.56 Quite High
positron emission tomography 16 70.32 Quite High
headache 1 25.00 Low Low
cytokine 42 5.00 Very Low Very Low Very Low
Inflammation 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 254 98.78 Very High Very High Very High
Apoptosis 33 98.72 Very High Very High Very High
Cv General 2 Under Development 4 98.64 Very High Very High Very High
Carcinoma 15 96.60 Very High Very High Very High
Myocardial Infarction 1 93.40 High High
Head & Neck Cancer 7 93.32 High High
Necrosis 3 93.16 High High
Acid Base Imbalance 1 92.56 High High
Convulsion 5 91.76 High High
Diplopia 1 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Postmortem results revealed low erythrocyte transketolase activity, which was increased by 22% by in vitro addition of thiamine diphosphate (TDP effect).
Positive_regulation (increased) of erythrocyte transketolase in erythrocyte
1) Confidence 0.69 Published 1997 Journal Intensive Care Med Section Abstract Doc Link 9201534 Disease Relevance 0.81 Pain Relevance 0.04
In addition, younger men, like the young women, did not acquire much TK due to dynamic of the local economy.
Neg (not) Positive_regulation (acquire) of TK
2) Confidence 0.41 Published 2008 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC2275234 Disease Relevance 0 Pain Relevance 0
We previously reported that this enhancement occurred in parallel with the priming agent-induced increase in protein tyrosyl phosphorylation which is sensitive to tyrosine kinase (TK) inhibitors [Akimaru K. et al.
Positive_regulation (sensitive) of TK
3) Confidence 0.23 Published 1993 Journal Physiol Chem Phys Med NMR Section Abstract Doc Link 7686297 Disease Relevance 0.28 Pain Relevance 0.34
Serum tumor markers such as sIL-2R (soluble interleukin-2 receptor) and TK (thymidine kinase) were elevated to 2870 U/ml and 15 U/L, respectively, but CEA (Carcinoembryonic Antigen), CA 19-9 (Carbohydrate Antigen 19-9) and NSE (Neuron-specific enolase) were normal.
Positive_regulation (elevated) of TK in Neuron associated with cancer
4) Confidence 0.12 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2615780 Disease Relevance 0.92 Pain Relevance 0.19
Activation of EGFR by ligands, such as EGF, leads to receptor dimerization and activation of intrinsic tyrosine kinase (TK) activity.
Positive_regulation (activation) of TK
5) Confidence 0.12 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2699661 Disease Relevance 0.98 Pain Relevance 0
These vectors retained an intact viral tk gene and contained a lac Z insertional mutation within the gene encoding RR, while MGH-1 bore additional mutation at both ?
Positive_regulation (intact) of tk
6) Confidence 0.12 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.82 Pain Relevance 0.24
Cetuximab competitively blocks the binding of the EGF and other ligands to the EGFR thus preventing the activation of the downstream TK resulting in growth arrest and apoptosis (Gill et al 1984; Sato et al 1983; Baselga 2000).
Positive_regulation (activation) of TK in Gill associated with apoptosis
7) Confidence 0.09 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721286 Disease Relevance 0.50 Pain Relevance 0

General Comments

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