INT51264

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Context Info
Confidence 0.54
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 10.69
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TXK) nucleus (TXK) DNA binding (TXK)
cytoplasm (TXK)
Anatomy Link Frequency
blood 1
interstitial cells 1
pituitary 1
internal 1
TXK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 56 97.92 Very High Very High Very High
Pain 14 97.36 Very High Very High Very High
Inflammation 93 94.28 High High
cINOD 11 92.16 High High
agonist 9 86.84 High High
aspirin 7 86.48 High High
chemokine 105 70.72 Quite High
corticosteroid 38 69.48 Quite High
Bioavailability 12 58.20 Quite High
Inflammatory stimuli 5 53.48 Quite High
Disease Link Frequency Relevance Heat
Cancer 521 99.78 Very High Very High Very High
Hypereosinophilic Syndrome 10 99.76 Very High Very High Very High
Chronic Myeloid Leukemia 3 99.10 Very High Very High Very High
Mouth Ulcer 4 99.02 Very High Very High Very High
Pituitary Cancer 6 98.92 Very High Very High Very High
Disease 323 97.68 Very High Very High Very High
Breast Cancer 240 96.88 Very High Very High Very High
Carcinoma 11 96.60 Very High Very High Very High
Lung Cancer 55 95.76 Very High Very High Very High
Malignant Neoplastic Disease 34 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fusion results in a novel tyrosine kinase that is constitutively activated and may induce proliferation ofhaematopoietic cells.
Positive_regulation (activated) of tyrosine kinase
1) Confidence 0.54 Published 2006 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 16768284 Disease Relevance 0.80 Pain Relevance 0.10
[A man with oral ulcers caused by hypereosinophilic syndrome and a good response to the tyrosine-kinase inhibitor imatinib].
Positive_regulation (response) of tyrosine-kinase associated with hypereosinophilic syndrome and mouth ulcer
2) Confidence 0.39 Published 2006 Journal Ned Tijdschr Geneeskd Section Title Doc Link 16768284 Disease Relevance 0.86 Pain Relevance 0.14
We previously reported that this enhancement occurred in parallel with the priming agent-induced increase in protein tyrosyl phosphorylation which is sensitive to tyrosine kinase (TK) inhibitors [Akimaru K. et al.
Positive_regulation (sensitive) of tyrosine kinase
3) Confidence 0.25 Published 1993 Journal Physiol Chem Phys Med NMR Section Abstract Doc Link 7686297 Disease Relevance 0.28 Pain Relevance 0.29
The receptor molecules consist of an extracellular ligand binding domain and an intracellular tyrosine kinase that is activated via conformational change in the intracellular protein domain due to extracellular ligand binding and receptor dimerization; the activation of the tyrosine kinase results in phosphorylation of intracellular substrate proteins, kicking off an intracellular reaction cascade regulating cell function and division, apoptosis, adhesion, motility and neoangiogenesis [17].
Positive_regulation (activated) of tyrosine kinase associated with apoptosis and adhesions
4) Confidence 0.19 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1524973 Disease Relevance 0.46 Pain Relevance 0
Ligand binding induces dimerization of the cell-surface receptors resulting in auto-phosphorylation of the cytoplasmic domains and activation of the receptor’s tyrosine kinase (Olayioye et al 2000; Schlessinger 2000).
Positive_regulation (activation) of tyrosine kinase
5) Confidence 0.17 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.26 Pain Relevance 0
The receptor molecules consist of an extracellular ligand binding domain and an intracellular tyrosine kinase that is activated via conformational change in the intracellular protein domain due to extracellular ligand binding and receptor dimerization; the activation of the tyrosine kinase results in phosphorylation of intracellular substrate proteins, kicking off an intracellular reaction cascade regulating cell function and division, apoptosis, adhesion, motility and neoangiogenesis [17].
Positive_regulation (activation) of tyrosine kinase associated with apoptosis and adhesions
6) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1524973 Disease Relevance 0.47 Pain Relevance 0
activation of the tyrosine kinase.
Positive_regulation (activation) of tyrosine kinase
7) Confidence 0.12 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.12 Pain Relevance 0
required for the activation of the internal tyrosine kinase.
Positive_regulation (activation) of tyrosine kinase in internal
8) Confidence 0.12 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0 Pain Relevance 0
Data also support the use of EGFR tyrosine kinase inhibitors in combination with HER2 antibodies, such as trastuzumab, against breast tumors that express EGFR and high levels of HER2 [37].
Positive_regulation (use) of tyrosine kinase associated with breast cancer
9) Confidence 0.11 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.42 Pain Relevance 0.04
Imatinib, a receptor tyrosine kinase inhibitor, was first used in the treatment of chronic myelogenous leukemia, which is characterized by the constitutive activation of the Bcr-Abl tyrosine kinase [5].
Positive_regulation (activation) of tyrosine kinase associated with chronic myeloid leukemia
10) Confidence 0.09 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2661077 Disease Relevance 0.59 Pain Relevance 0
Activation of EGFR by ligands, such as EGF, leads to receptor dimerization and activation of intrinsic tyrosine kinase (TK) activity.
Positive_regulation (activation) of tyrosine kinase
11) Confidence 0.09 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2699661 Disease Relevance 0.97 Pain Relevance 0
Activation of the EGFR tyrosine kinase phosphorylates
Positive_regulation (Activation) of tyrosine kinase
12) Confidence 0.07 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.21 Pain Relevance 0
Functional analyses of these mutant EGFRs in the cultured cells demonstrated that all EGFR mutants have enhanced tyrosine kinase activity in response to epidermal growth factor and increased sensitivity to EGFR inhibitor Erlotinib.
Positive_regulation (enhanced) of tyrosine kinase
13) Confidence 0.05 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2970593 Disease Relevance 0.42 Pain Relevance 0
In this landmark publication, the group reported the finding of activating KIT mutations in a significant proportion of GISTs, with constitutive ligand-independent activation of the KIT-receptor tyrosine kinase (RTK), and a near universal expression of KIT on immunohistochemistry.7 Corroborated by Kindblom and others, it was demonstrated that GIST cells were closely related to the interstitial cells of Cajal.8 This understanding provided the platform for accurate and uniform diagnoses of this uncommon tumor and the rational development and use of tyrosine kinase inhibitors (TKI) in the management of GIST.


Neg (independent) Positive_regulation (activation) of tyrosine kinase in interstitial cells associated with cancer and gastrointestinal stromal tumor
14) Confidence 0.02 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819895 Disease Relevance 1.47 Pain Relevance 0
More recently, several studies proposed that CXCR4-dependent activation of ERK1/2 was mediated by transactivation of tyrosine kinase receptors.
Positive_regulation (transactivation) of tyrosine kinase
15) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.60 Pain Relevance 0.12
The authors concluded that tyrosine kinase activity is crucial for the integrity and growth of pituitary adenomas in culture and that growth factors released by pituitary adenomas potentially may maintain and promote tumor growth by stimulating tyrosine kinase activity [106].
Positive_regulation (stimulating) of tyrosine kinase in pituitary associated with cancer and pituitary cancer
16) Confidence 0.02 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.60 Pain Relevance 0.03
The mechanism of growth factor receptors is via activation of the intracellular tyrosine kinase domain, which triggers downstream targets and subsequently cell proliferation and survival [34].
Positive_regulation (activation) of tyrosine kinase
17) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2814233 Disease Relevance 0.95 Pain Relevance 0
At 400 mg per day the blood concentration of imatinib was consistently higher than that required for 50% Bcr-Abl tyrosine kinase activity in vitro (Peng et al 2004; Schmidli et al 2005). 600 mg per day was likely to be more effective in accelerated and blastic phase CML and increasing the dose up to 800 mg per day can benefit a subgroup with either an inadequate cytogenetic response or disease progression (Kantarjian et al 2003a; Zonder et al 2003).
Positive_regulation (required) of tyrosine kinase in blood associated with myeloid leukemia and disease progression
18) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.30 Pain Relevance 0
Mutations in this proto-oncogene commonly cause constitutive activation of the KIT tyrosine kinase receptor, an important factor in the pathogenesis of the disease.
Positive_regulation (activation) of tyrosine kinase associated with disease
19) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2503651 Disease Relevance 0.70 Pain Relevance 0
engagement of this receptor complex leads to the initiation of complex signaling events leading to protein tyrosine phosphorylation and activation of the src-family kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52].
Positive_regulation (activation) of tyrosine kinase
20) Confidence 0.01 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.05 Pain Relevance 0.07

General Comments

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