INT51265

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Context Info
Confidence 0.81
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 25.33
Pain Relevance 10.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
plasma 1
joints 1
leukocyte 1
microglia 1
SK-N-SH 1
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 464 100.00 Very High Very High Very High
cytokine 519 99.84 Very High Very High Very High
aspirin 8 99.84 Very High Very High Very High
Inflammation 587 99.36 Very High Very High Very High
methotrexate 63 99.10 Very High Very High Very High
Arthritis 357 98.96 Very High Very High Very High
abatacept 123 98.74 Very High Very High Very High
Infliximab 63 97.76 Very High Very High Very High
Adalimumab 73 96.24 Very High Very High Very High
Calcium channel 12 93.88 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 540 100.00 Very High Very High Very High
Cancer 231 100.00 Very High Very High Very High
Necrosis 84 100.00 Very High Very High Very High
Targeted Disruption 110 99.96 Very High Very High Very High
Stress 79 99.82 Very High Very High Very High
Apoptosis 155 99.80 Very High Very High Very High
INFLAMMATION 696 99.36 Very High Very High Very High
Latent Tuberculosis 6 99.34 Very High Very High Very High
Death 71 99.20 Very High Very High Very High
Arthritis 144 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the Bio-Plex Manager software, serum levels of TNF?
Phosphorylation (levels) of TNF
1) Confidence 0.81 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991021 Disease Relevance 0.44 Pain Relevance 0.49
Most notably, however, the concentrations of TNF-?
Phosphorylation (concentrations) of TNF
2) Confidence 0.80 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.53 Pain Relevance 0.29
-catenin phosphorylation by TNF-?
Phosphorylation (phosphorylation) of TNF
3) Confidence 0.80 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.51 Pain Relevance 0.12
Importantly, moreover, SF concentrations of TNF-?
Phosphorylation (concentrations) of TNF
4) Confidence 0.79 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778712 Disease Relevance 1.30 Pain Relevance 0.36
The increased concentrations of TNF-?
Phosphorylation (concentrations) of TNF
5) Confidence 0.79 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.47 Pain Relevance 0.37
A correlation between IL-1 and TNF-?
Phosphorylation (correlation) of TNF
6) Confidence 0.79 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2837669 Disease Relevance 1.72 Pain Relevance 0.65
The students with lower serum levels of omega-3s had a significantly greater stress-induced elevation of TNF-?
Phosphorylation (elevation) of TNF associated with stress
7) Confidence 0.79 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1855049 Disease Relevance 1.43 Pain Relevance 0.50
Our study clearly addresses this concern by demonstrating the lack of TNF?
Neg (lack) Phosphorylation (lack) of TNF
8) Confidence 0.79 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2441623 Disease Relevance 1.10 Pain Relevance 0.08
For either the stimulation or inhibition of the TNF-?
Phosphorylation (stimulation) of TNF
9) Confidence 0.79 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.28 Pain Relevance 0
The concentration of tumor necrosis factor (TNF)-?
Phosphorylation (concentration) of TNF associated with necrosis and cancer
10) Confidence 0.79 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Abstract Doc Link PMC2778712 Disease Relevance 1.21 Pain Relevance 0.27
The concentration of IL and TNF-?
Phosphorylation (concentration) of TNF
11) Confidence 0.74 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2984415 Disease Relevance 0.66 Pain Relevance 0.16
The possibility of reactivation of latent tuberculosis (Tb) is an area of concern with the arrival of anti-TNF-?
Phosphorylation (arrival) of anti-TNF associated with latent tuberculosis
12) Confidence 0.71 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504074 Disease Relevance 1.43 Pain Relevance 0.55
Increased lymphangiogenesis in joints of tumor necrosis factor-transgenic mice
Phosphorylation (joints) of tumor necrosis factor in joints associated with targeted disruption, necrosis and cancer
13) Confidence 0.69 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.83 Pain Relevance 0.05
The polymorphism of TNF alleles and association with malaria pathogenicity/susceptibility/severity
Phosphorylation (polymorphism) of TNF associated with malaria
14) Confidence 0.68 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 0.61 Pain Relevance 0
Effect of indomethacin and aspirin on the TNF-alpha-induced priming and protein tyrosyl phosphorylation of human neutrophils.
Phosphorylation (phosphorylation) of TNF-alpha in neutrophils associated with aspirin
15) Confidence 0.61 Published 1993 Journal Physiol Chem Phys Med NMR Section Title Doc Link 7686297 Disease Relevance 0.26 Pain Relevance 0.41
B = nuclear factor-kappa-B; NO = nitric oxide; PBL = peripheral blood-derived mononuclear leukocyte; PBS = phosphate-buffered saline; PGE2 = prostaglandin E2; PHA = phytohemagglutinin-P; RA = rheumatoid arthritis; RU = rutoside; s.c. = subcutaneous; TNF-?
Phosphorylation (phosphate) of TNF in leukocyte associated with rheumatoid arthritis
16) Confidence 0.58 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.96 Pain Relevance 0.38
Western blot analyses revealed that hCG-A impaired TNF-alpha-mediated phosphorylation and degradation of the inhibitor IkappaBalpha suggesting that the hormone may reduce nuclear import of NF-kappaB by stabilizing its inhibitor.
Phosphorylation (phosphorylation) of TNF-alpha
17) Confidence 0.50 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.34 Pain Relevance 0.21
In this study, plasma concentrations of TNF?
Phosphorylation (concentrations) of TNF in plasma
18) Confidence 0.43 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.53 Pain Relevance 0.06
Surprisingly, the frequency of TNF?
Phosphorylation (frequency) of TNF
19) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.78 Pain Relevance 0.43
Abatacept plus methotrexate in patients with rheumatoid arthritis and a history of TNF-?
Phosphorylation (history) of TNF associated with rheumatoid arthritis, abatacept and methotrexate
20) Confidence 0.43 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582812 Disease Relevance 0.39 Pain Relevance 1.20

General Comments

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