INT5127

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Context Info
Confidence 0.80
First Reported 1980
Last Reported 2010
Negated 0
Speculated 6
Reported most in Abstract
Documents 488
Total Number 494
Disease Relevance 50.48
Pain Relevance 162.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 30
blood 12
plasma 9
follicle 8
hypothalamus 8
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 1615 100.00 Very High Very High Very High
antagonist 359 100.00 Very High Very High Very High
opioid receptor 56 100.00 Very High Very High Very High
agonist 651 99.92 Very High Very High Very High
excitatory amino acid 54 99.92 Very High Very High Very High
Clonidine 39 99.92 Very High Very High Very High
Endogenous opioid 310 99.88 Very High Very High Very High
Opioid 458 99.84 Very High Very High Very High
opiate 268 99.82 Very High Very High Very High
Morphine 201 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 420 100.00 Very High Very High Very High
Hypoglycemia 86 99.92 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 4 99.92 Very High Very High Very High
Hypothyroidism 7 99.84 Very High Very High Very High
Precocious Puberty 6 99.84 Very High Very High Very High
Stress 137 99.70 Very High Very High Very High
Opiate Addiction 1 99.62 Very High Very High Very High
Anovulation 14 99.60 Very High Very High Very High
Migraine Without Aura 10 99.54 Very High Very High Very High
Delayed Puberty 18 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LHRH infusion induced a biphasic release of LH in intact animals of both sexes and in castrated females but not in castrated males.
Localization (release) of LH
1) Confidence 0.80 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.14
The biphasic pattern of LH release was characterized by an initial acute rise followed by a plateau or a fall and the consecutive second rise after a long latent period.
Localization (release) of LH
2) Confidence 0.80 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6349979 Disease Relevance 0 Pain Relevance 0.13
Effects of the opiate agonist, morphine, and antagonist, naloxone, on LH release, courtship behavior and ejaculation frequency of mature, sexually active or sexually inactive rams were investigated.
Localization (release) of LH associated with antagonist, narcan, agonist, opiate and morphine
3) Confidence 0.80 Published 1994 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 7956174 Disease Relevance 0 Pain Relevance 0.52
GnRH stimulated the secretion of I-LH (2-4-fold), F-LH and B-LH (3-5-fold each) in all groups studied.
Localization (secretion) of F-LH
4) Confidence 0.80 Published 1991 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 1927298 Disease Relevance 0.48 Pain Relevance 0.19
GnRH stimulated the secretion of I-LH (2-4-fold), F-LH and B-LH (3-5-fold each) in all groups studied.
Localization (secretion) of I-LH
5) Confidence 0.80 Published 1991 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 1927298 Disease Relevance 0.48 Pain Relevance 0.19
GnRH stimulated the secretion of I-LH (2-4-fold), F-LH and B-LH (3-5-fold each) in all groups studied.
Localization (secretion) of B-LH
6) Confidence 0.80 Published 1991 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 1927298 Disease Relevance 0.48 Pain Relevance 0.19
However, changes in opioid inhibition are unlikely to underlie the decrease in sensitivity to steroid negative feedback and increase in pulsatile LH secretion that occur at puberty.
Localization (secretion) of LH associated with opioid
7) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.09 Pain Relevance 0.60
Naloxone treatment (hourly iv injections of 1 mg/kg BW for 4 h) produced an increase in the frequency of episodic LH secretion at all prepubertal ages, when lambs were highly sensitive to the estradiol negative feedback.
Localization (secretion) of LH associated with narcan
8) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.61
However, increases in LH pulse frequency were also induced by naloxone treatment at a postpubertal age in estradiol-treated OVX sheep, indicating that opioid inhibition is still present at a time when sensitivity to the feedback effects of ovarian steroids is markedly reduced and endogenous LH secretion is increased.
Localization (secretion) of LH associated with narcan and opioid
9) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.73
Naloxone also increased LH pulse frequency in OVX lambs in which LH secretion was inhibited chronically by progesterone rather than by estradiol.
Localization (secretion) of LH associated with narcan
10) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.06 Pain Relevance 0.77
We conclude that endogenous opioid mechanisms are an important inhibitory mechanism controlling pulsatile LH secretion in the developing sheep.
Localization (secretion) of LH associated with endogenous opioid
11) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.10 Pain Relevance 0.75
In addition, after removal of steroid implants to allow LH secretion to increase, the degree of inhibition of LH secretion by the opiate agonist morphine was similar between age-matched postpubertal sheep and those with photoperiodically delayed puberty.
Localization (secretion) of LH associated with delayed puberty, agonist, opiate and morphine
12) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.10 Pain Relevance 0.83
The developing female sheep, which attains puberty after 25 weeks of age, was used as an experimental model to investigate the role of endogenous opioid peptides in the control of pulsatile LH secretion during sexual maturation.
Localization (secretion) of LH associated with endogenous opioid
13) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.39
Treatment of ovary-intact prepubertal sheep at 12 weeks of age with the opiate antagonist naloxone resulted in a dose-dependent increase in LH secretion.
Localization (secretion) of LH in ovary associated with antagonist, narcan and opiate
14) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.49
Endogenous opioid inhibition of LH secretion is not dependent on the presence of ovarian steroids, as evidenced by the response to naloxone 3 weeks after removal of an estradiol implant from OVX lambs, when LH pulse frequency was already high.
Localization (secretion) of LH associated with narcan and endogenous opioid
15) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0 Pain Relevance 0.76
In addition, after removal of steroid implants to allow LH secretion to increase, the degree of inhibition of LH secretion by the opiate agonist morphine was similar between age-matched postpubertal sheep and those with photoperiodically delayed puberty.
Localization (secretion) of LH associated with delayed puberty, agonist, opiate and morphine
16) Confidence 0.79 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.09 Pain Relevance 0.85
The working hypothesis for this study was that 17 beta-estradiol (E2), progesterone (P4), and opioid neuropeptides modulate frequency of pulsatile release of LH during the luteal phase of the bovine estrous cycle.
Localization (release) of LH associated with neuropeptide and opioid
17) Confidence 0.78 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8286576 Disease Relevance 0 Pain Relevance 0.41
The greatest amplitude (p < 0.01) of LH release after LHRH was in cows treated with E2 alone.
Localization (release) of LH
18) Confidence 0.78 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8286576 Disease Relevance 0 Pain Relevance 0.45
The parallelism in the LH responses to both antagonists in these hyperprolactinemic patients lends further support to a functional link between opioid and dopamine regulation of LH secretion.
Localization (secretion) of LH associated with dopamine, antagonist and opioid
19) Confidence 0.78 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3760121 Disease Relevance 0.08 Pain Relevance 0.88
Endogenous opiate peptides are considered to inhibit LH secretion via a dopaminergic mechanism, and increased opioid inhibition of LH secretion has been found in some hyperprolactinemic women with a pituitary microadenoma.
Localization (secretion) of LH in pituitary associated with opiate and opioid
20) Confidence 0.78 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3760121 Disease Relevance 0.07 Pain Relevance 0.75

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