INT51275

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Context Info
Confidence 0.35
First Reported 1993
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.98
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGF1, INS) extracellular region (IGF1, INS) signal transduction (IGF1)
small molecule metabolic process (INS) carbohydrate metabolic process (INS) cell-cell signaling (INS)
IGF1 (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 93.96 High High
headache 1 69.12 Quite High
Clonidine 1 63.44 Quite High
Disease Link Frequency Relevance Heat
Arthralgia 1 94.60 High High
Pain 2 93.96 High High
Pressure And Volume Under Development 2 93.56 High High
Body Weight 1 86.32 High High
Diabetes Mellitus 8 75.00 Quite High
Laron Syndrome 1 75.00 Quite High
Headache 1 69.12 Quite High
Papilledema 1 67.52 Quite High
Paralysis 1 65.52 Quite High
Hypoglycemia 1 50.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To analyze the mechanism by which IGF-I/IGFBP-3 might reduce insulin requirements, the change in serum GH was quantified.
IGF-I Spec (might) Negative_regulation (reduce) of insulin
1) Confidence 0.35 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10770191 Disease Relevance 0.50 Pain Relevance 0.14
We conclude that rhIGF-I/rhIGFBP-3 significantly lowers insulin requirements yet improves glucose values and these changes may reflect improvement in insulin sensitivity.
rhIGF-I Negative_regulation (lowers) of insulin
2) Confidence 0.26 Published 2005 Journal Growth Horm. IGF Res. Section Abstract Doc Link 16005252 Disease Relevance 0.36 Pain Relevance 0.09
We conclude that IGF-I (40 micrograms/kg every 12 h) given sc to adults with GHRD is safe; achieves normal levels of IGF-I; reduces insulin, IGF-II, and GH levels; and increases IGFBP-2 concentrations and urinary excretion of calcium.
IGF-I Negative_regulation (reduces) of insulin
3) Confidence 0.15 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7686916 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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