INT51279

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2009
Negated 4
Speculated 7
Reported most in Body
Documents 17
Total Number 24
Disease Relevance 15.89
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) nucleus (IGFBP3)
Anatomy Link Frequency
blood 1
plasma 1
fibroblasts 1
molar 1
Body 1
IGFBP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 20 99.20 Very High Very High Very High
rheumatoid arthritis 12 98.44 Very High Very High Very High
spinal inflammation 10 97.24 Very High Very High Very High
aspirin 1 93.12 High High
cINOD 8 92.48 High High
Dynorphin 3 83.16 Quite High
Pain 3 72.88 Quite High
Bioavailability 8 65.52 Quite High
cytokine 22 62.96 Quite High
fibrosis 6 45.84 Quite Low
Disease Link Frequency Relevance Heat
Stress 4 100.00 Very High Very High Very High
Endometriosis (extended) 5 99.68 Very High Very High Very High
Sleep Disorders 208 99.60 Very High Very High Very High
Disease 39 99.54 Very High Very High Very High
Hypoxia 52 99.14 Very High Very High Very High
Cancer 53 98.96 Very High Very High Very High
Apoptosis 188 98.70 Very High Very High Very High
Rheumatoid Arthritis 12 98.44 Very High Very High Very High
Adhesions 258 97.60 Very High Very High Very High
Low Back Pain 10 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They may also attain a high proliferating nature due to up regulation of S100A10 and CSPG2 genes, and down regulation of IGFBP3 (Table 2).
Regulation (regulation) of IGFBP3
1) Confidence 0.49 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.26 Pain Relevance 0.06
Body size indicators, vigorous physical activity, and dietary factors appeared to influence serum levels of IGF-1 and the ratio of IGF-1 to IGFBP-3 in pre-menopausal women more than in post-menopausal women.
Regulation (influence) of IGFBP-3 in Body associated with endometriosis (extended)
2) Confidence 0.42 Published 2005 Journal Cancer Causes Control Section Abstract Doc Link 16215864 Disease Relevance 0.43 Pain Relevance 0.14
Furthermore, all subjects in the present study were healthy, with no known confounding disease or condition that may influence IGF-1 or IGFBP-3 concentrations.
Spec (may) Regulation (influence) of IGFBP-3 associated with disease
3) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671651 Disease Relevance 1.16 Pain Relevance 0
Furthermore, subjects were often not matched for gender and/or age, both known to influence systemic IGF-1 and IGFBP-3 concentrations.
Regulation (influence) of IGFBP-3
4) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669552 Disease Relevance 1.29 Pain Relevance 0
Furthermore, all subjects in the present study were healthy, with no known confounding disease or condition that may influence IGF-1 or IGFBP-3 concentrations.
Spec (may) Regulation (influence) of IGFBP-3 associated with disease
5) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669552 Disease Relevance 1.16 Pain Relevance 0
Furthermore, subjects were often not matched for gender and/or age, both known to influence systemic IGF-1 and IGFBP-3 concentrations.
Regulation (influence) of IGFBP-3
6) Confidence 0.42 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671651 Disease Relevance 1.29 Pain Relevance 0
This study was performed to determine the effects of short-term dynamic exercise on serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels in the patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS).
Spec (determine) Regulation (effects) of insulin-like growth factor binding protein-3 associated with spinal inflammation and rheumatoid arthritis
7) Confidence 0.33 Published 2007 Journal Clin. Rheumatol. Section Abstract Doc Link 17322964 Disease Relevance 1.10 Pain Relevance 0.82
Multiple mechanisms may control IGFBP-3 actions.
Spec (may) Regulation (control) of IGFBP-3
8) Confidence 0.27 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 0.88 Pain Relevance 0
However, assessment of IGF1 concentration and IGFBP3/IGF1 values in the Acclydine group at baseline, 4 wk, and 8 wk during treatment, at the end of treatment, and at follow-up (1 mo after the treatment period) did not show a significant change.
Regulation (values) of IGFBP3
9) Confidence 0.26 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1876596 Disease Relevance 0.36 Pain Relevance 0
We studied the GH response to provocation by clonidine and glucagon, measured the circulating concentrations of insulin, IGF-I, IGF-binding protein-3 (IGFBP-3) and ferritin, and evaluated IGF-I generation after a single dose of GH (0.1 mg/kg per dose) in 15 prepubertal patients with thalassaemia, 15 age-matched children with constitutional short stature (CSS) (height standard deviation score less than -2, with normal GH response to provocation) and 11 children with isolated GH deficiency (GHD).
Regulation (concentrations) of IGF-binding protein-3 associated with thalassemia, growth problems and clonidine
10) Confidence 0.25 Published 1998 Journal Eur. J. Endocrinol. Section Abstract Doc Link 9578506 Disease Relevance 0.58 Pain Relevance 0.16
As IGFBP3 is known to have modulatory effects on transcription, for example through its binding to nur 77 [21], a possible explanation for IGFBP3 effects on sleep could be transcriptional modulation of the preprohypocretin gene.
Spec (possible) Regulation (explanation) of IGFBP3
11) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.46 Pain Relevance 0
Data obtained in our study also indicate that adhesion fibroblasts may resist apoptosis due to anti apoptotic effects mediated by increased hMet1-e and CSPG2 levels and down regulation of IGFBP3.
Regulation (regulation) of IGFBP3 in fibroblasts associated with apoptosis and adhesions
12) Confidence 0.24 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.26 Pain Relevance 0.06
However, this correlation was weak (r = 0.12) suggesting that colonic tissue IGFBP-3 levels may have only small a contribution to plasma IGFBP-3 given that other tissue sources also influence plasma IGFBP-3 levels.
Regulation (influence) of plasma IGFBP-3 in plasma
13) Confidence 0.24 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.39 Pain Relevance 0.03
Percent change in IGF-I and IGFBP-3 during the somatomedin generation test was not significantly affected by zinc supplementation (118% vs 136% and 57% vs 44%, respectively).
Regulation (change) of IGFBP-3
14) Confidence 0.22 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 15679071 Disease Relevance 0.22 Pain Relevance 0.32
Although IGF-binding protein-3 (IGFBP-3) levels were not significantly influenced, baseline IGFBP-2 levels (153% of the control) increased 45% (P < 0.01).
Neg (not) Regulation (influenced) of IGF-binding protein-3
15) Confidence 0.20 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7686916 Disease Relevance 0.13 Pain Relevance 0.07
Although IGF-binding protein-3 (IGFBP-3) levels were not significantly influenced, baseline IGFBP-2 levels (153% of the control) increased 45% (P < 0.01).
Neg (not) Regulation (influenced) of IGFBP-3
16) Confidence 0.20 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7686916 Disease Relevance 0.13 Pain Relevance 0.07
These results suggest a direct stimulatory effect of zinc on serum IGF-IGFBP-3, alkaline phosphatase and osteocalcin.
Regulation (effect) of serum IGF-IGFBP-3
17) Confidence 0.19 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 15679071 Disease Relevance 0.07 Pain Relevance 0.22
We investigated whether human narcolepsy is associated with dysregulated IGFBP3 levels in the blood and CSF.
Spec (whether) Regulation (dysregulated) of IGFBP3 in blood associated with sleep disorders
18) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.49 Pain Relevance 0.04
To test whether IGFBP3 activity regulates hypocretin levels in vivo, DNA samples of 262 Caucasian subjects with normal CSF hypocretin-1 levels (>200 pg/ml), either drawn from healthy control subjects or from subjects with a complaint of sleepiness unexplained by hypocretin deficiency, were typed for rs2854744 (?
Spec (whether) Regulation (regulates) of IGFBP3 associated with sleep disorders
19) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.44 Pain Relevance 0
RESULTS: Basal GH, IGF-I, insulin-like growth factor binding protein-3 (IGFBP-3) plasma levels and the IGF-I/IGFBP-3 molar ratio remained unaffected by NTX.
Neg (unaffected) Regulation (unaffected) of insulin-like growth factor binding protein-3 in molar
20) Confidence 0.16 Published 1997 Journal Eur. J. Endocrinol. Section Body Doc Link 9437228 Disease Relevance 0 Pain Relevance 0

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