INT5128

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2010
Negated 7
Speculated 7
Reported most in Abstract
Documents 232
Total Number 239
Disease Relevance 44.23
Pain Relevance 71.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 36
follicle 9
pituitary 5
shoulder 4
neurons 3
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 717 100.00 Very High Very High Very High
Opioid 231 100.00 Very High Very High Very High
Clonidine 14 100.00 Very High Very High Very High
member 8 2 100.00 Very High Very High Very High
antagonist 144 99.98 Very High Very High Very High
addiction 14 99.96 Very High Very High Very High
headache 17 99.86 Very High Very High Very High
opiate 110 99.84 Very High Very High Very High
transdermal 4 99.82 Very High Very High Very High
mu opioid receptor 7 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 139 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 102 100.00 Very High Very High Very High
Stress 54 100.00 Very High Very High Very High
Aging 28 100.00 Very High Very High Very High
Appetite Loss 16 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Sleep Disorders 52 99.98 Very High Very High Very High
Ovarian Cancer 32 99.96 Very High Very High Very High
Headache 17 99.86 Very High Very High Very High
Anxiety 6 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of high doses of naloxone, an opiate antagonist, produces an increase in plasma concentration of LH.
Positive_regulation (increase) of LH in plasma associated with antagonist, narcan and opiate
1) Confidence 0.69 Published 1996 Journal Arch. Androl. Section Abstract Doc Link 8827343 Disease Relevance 0 Pain Relevance 0.48
Amplitude of the naloxone-induced LH response was greater (P less than .05) for ovariectomized (5.9 +/- 1.1 ng/ml) than for intact groups (2.7 +/- .5 ng/ml).
Positive_regulation (induced) of LH associated with narcan
2) Confidence 0.69 Published 1989 Journal J. Anim. Sci. Section Abstract Doc Link 2670869 Disease Relevance 0 Pain Relevance 0.32
Naloxone also increased LH pulse frequency in OVX lambs in which LH secretion was inhibited chronically by progesterone rather than by estradiol.
Positive_regulation (increased) of LH associated with narcan
3) Confidence 0.68 Published 1989 Journal Endocrinology Section Abstract Doc Link 2737153 Disease Relevance 0.05 Pain Relevance 0.77
In contrast, 7 of the 11 hyperprolactinemic women responded to both antagonists with a significant increase in LH levels.
Positive_regulation (increase) of LH associated with antagonist
4) Confidence 0.68 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3760121 Disease Relevance 0.09 Pain Relevance 0.92
In elderly men (n = 11) only a borderline significant increase in baseline plasma LH levels occurred, and neither LH pulse frequency nor the sum of the amplitudes of LH pulses increased.
Positive_regulation (increase) of LH in plasma
5) Confidence 0.68 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2909555 Disease Relevance 0.07 Pain Relevance 0.16
Naltrexone administration (40 mg at 0630 and 2200 h the day before blood sampling and at 0630 h, 30 min before starting frequent blood sampling at 10-min intervals for 12 h) to young men (n = 8) induced a significant increase in individual mean baseline plasma LH levels, LH pulse frequency, and the sum of LH pulse amplitudes.
Positive_regulation (increase) of LH in plasma
6) Confidence 0.68 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2909555 Disease Relevance 0.07 Pain Relevance 0.15
In the mature ewes, there was a trend for naloxone to increase LH values during the early anoestrous period but naloxone was without effect during mid- and late anoestrus.
Positive_regulation (increase) of LH associated with narcan
7) Confidence 0.67 Published 1986 Journal J. Reprod. Fertil. Section Abstract Doc Link 3701707 Disease Relevance 0 Pain Relevance 0.67
Jugular venous infusion of naloxone (25, 50 or 100 mg/h for 8h) into 5 ewes during the early and mid-luteal phase of the cycle resulted overall in a significant increase in mean plasma LH concentrations and LH episode frequency.
Positive_regulation (increase) of LH in plasma associated with narcan
8) Confidence 0.67 Published 1986 Journal J. Reprod. Fertil. Section Abstract Doc Link 3701707 Disease Relevance 0 Pain Relevance 0.78
Pentobarbital anesthesia delayed, but did not prevent, the EB-induced LH surge in peripubertal females, while it completely abolished the P-induced LH surge.
Positive_regulation (induced) of LH associated with anesthesia
9) Confidence 0.66 Published 1984 Journal Endocrinology Section Abstract Doc Link 6734515 Disease Relevance 0 Pain Relevance 0.10
Present data do not support a role for endogenous opioid peptides in the pathogenesis of increased LH levels in PCOS.


Positive_regulation (increased) of LH
10) Confidence 0.66 Published 1994 Journal Fertil. Steril. Section Body Doc Link 8034071 Disease Relevance 0 Pain Relevance 0
The same occurred after naltrexone treatment, when significant increases in both mean LH levels (P < 0.02) and LH response to GnRH (P < 0.025) were observed.
Positive_regulation (increases) of LH response
11) Confidence 0.66 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0.06 Pain Relevance 0.34
RESULTS: In comparison with normal cycling women, PCOS showed normal frequency and increased amplitude LH pulses, elevated mean LH levels, and increased LH response to GnRH.
Positive_regulation (elevated) of LH
12) Confidence 0.66 Published 1994 Journal Fertil. Steril. Section Body Doc Link 8034071 Disease Relevance 0 Pain Relevance 0
The same occurred after naltrexone treatment, when significant increases in both mean LH levels (P < 0.02) and LH response to GnRH (P < 0.025) were observed.
Positive_regulation (increases) of LH
13) Confidence 0.66 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7883843 Disease Relevance 0.06 Pain Relevance 0.34
Naloxone administration during the saline infusion did not increase either the mean plasma LH concentration (7.5 +/- 0.7 IU/L; P = NS vs. saline control) or the LH pulse frequency (0.69 +/- 0.1 pulses/boy.h; P = NS vs. saline control).
Neg (not) Positive_regulation (increase) of LH in plasma associated with narcan
14) Confidence 0.65 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7962287 Disease Relevance 0 Pain Relevance 0.24
Naloxone significantly increased plasma LH levels in the luteal, but not during the follicular phase of the cycle in both subject groups.
Positive_regulation (increased) of LH in plasma associated with narcan
15) Confidence 0.64 Published 1987 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 3034748 Disease Relevance 0.26 Pain Relevance 0.42
Naloxone increased mean LH and LH pulse frequency only in the four older, more mature boys during the infusion of saline.
Positive_regulation (increased) of LH associated with narcan
16) Confidence 0.63 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1955505 Disease Relevance 0 Pain Relevance 0.40
However, in the 3 patients who had had spontaneous menarche and in normal pubertal girls naloxone increased plasma LH levels.
Positive_regulation (increased) of LH in plasma associated with narcan
17) Confidence 0.62 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3129445 Disease Relevance 0.40 Pain Relevance 0.37
Naloxone did not increase plasma LH levels in the amenorrheic untreated and treated patients with Turner's syndrome.
Neg (not) Positive_regulation (increase) of LH in plasma associated with syndrome and narcan
18) Confidence 0.62 Published 1988 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3129445 Disease Relevance 0.38 Pain Relevance 0.32
During the follicular phase of the oestrous cycle, naloxone enhanced LH pulse frequency, which resulted in increased plasma LH concentrations; saline had no effect.
Positive_regulation (increased) of LH in plasma associated with narcan
19) Confidence 0.62 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2527942 Disease Relevance 0 Pain Relevance 0.36
A significant increase in the serum LH concentration (greater than or equal to 20% within 40 min of injection) was observed after naloxone administration in 60% of the trials conducted during the luteal phase.
Positive_regulation (increase) of LH associated with narcan
20) Confidence 0.60 Published 1983 Journal Endocrinology Section Abstract Doc Link 6414806 Disease Relevance 0 Pain Relevance 0.57

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