INT51298

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Context Info
Confidence 0.27
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.99
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r) plasma membrane (Ltb4r) signal transducer activity (Ltb4r)
Anatomy Link Frequency
muscle 2
sensory neurons 1
dorsal horn 1
trigeminal ganglion 1
neurons 1
Ltb4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 5 99.80 Very High Very High Very High
Trigeminal ganglion neurons 2 98.68 Very High Very High Very High
Root ganglion neuron 3 98.64 Very High Very High Very High
Hyperalgesia 2 97.80 Very High Very High Very High
substantia gelatinosa 4 96.12 Very High Very High Very High
spinal dorsal horn 6 95.80 Very High Very High Very High
Dorsal horn 15 94.96 High High
primary afferent fibers 3 93.96 High High
dorsal root ganglion 30 91.72 High High
parabrachial 2 90.52 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 99.88 Very High Very High Very High
Nociception 33 99.12 Very High Very High Very High
Ganglion Cysts 38 98.44 Very High Very High Very High
Hyperalgesia 12 97.80 Very High Very High Very High
Inflammatory Pain 3 89.76 High High
INFLAMMATION 9 78.52 Quite High
Nervous System Injury 1 76.72 Quite High
Neuropathic Pain 1 74.48 Quite High
Adhesions 2 71.44 Quite High
Eczema 1 69.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intradermal injection of LTB4 has been shown to produce both thermal and mechanical hyperalgesia [11,12].
LTB4 Binding (injection) of associated with hyperalgesia
1) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 1.21 Pain Relevance 0.80
Nociceptive nature of axon terminals showing mGluR7-like immunoreactivity (mGluR7-LI) was indicated by binding to the isolectin I-B4 from Griffonia simplicifolia (I-B4), or by substance P-like immunoreactivity (SP-LI).
I-B4 Binding (binding) of associated with nociception and substance p
2) Confidence 0.22 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9080455 Disease Relevance 0.27 Pain Relevance 0.30
The I-B4 isolectin from Bandeiraea simplicifolia exhibits specific binding to a subpopulation of rat dorsal root ganglion neurons of small diameter which terminate in the substantia gelatinosa of the dorsal horn.
I-B4 Binding (binding) of in dorsal root ganglion associated with ganglion cysts, substantia gelatinosa, dorsal horn and root ganglion neuron
3) Confidence 0.20 Published 1993 Journal Neuroscience Section Abstract Doc Link 7687755 Disease Relevance 0.10 Pain Relevance 0.18
The results revealed that Bandeiraea simplicifolia I-B4 binding is associated with over one-third of neurones which innervate the skin, but only a small proportion of neurones innervating muscle or viscera.
I-B4 Binding (binding) of in muscle
4) Confidence 0.14 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8264961 Disease Relevance 0.07 Pain Relevance 0
The results revealed that Bandeiraea simplicifolia I-B4 binding is associated with over one-third of neurones which innervate the skin, but only a small proportion of neurones innervating muscle or viscera.
I-B4 Binding (associated) of in muscle
5) Confidence 0.14 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8264961 Disease Relevance 0.07 Pain Relevance 0
As the I-B4 lectin appears to bind selectively to a subset of small-diameter primary afferents with cutaneous peripheral projections, we sought to determine whether it could be used as a transganglionic tracer which selectively labels the spinal terminations of cutaneous afferents in superficial dorsal horn.
I-B4 Binding (bind) of in dorsal horn associated with dorsal horn
6) Confidence 0.13 Published 1993 Journal Neuroscience Section Abstract Doc Link 7687755 Disease Relevance 0.09 Pain Relevance 0.31
The isolectin I-B4 (IB4) binds specifically to a subset of small sensory neurons.
I-B4 Binding (binds) of in sensory neurons
7) Confidence 0.03 Published 2001 Journal Neuroscience Section Abstract Doc Link 11738138 Disease Relevance 0.14 Pain Relevance 0.07
Vc neurons in direct contact with axonal varicosities that bind isolectin I-B4 were also considered nociceptive.
I-B4 Binding (bind) of in neurons associated with nociception and increased venous pressure under development
8) Confidence 0.02 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9214544 Disease Relevance 0.87 Pain Relevance 0.31
Confocal laser-scanning microscopy revealed that axonal varicosities with 5-HT-LI were in close apposition to TMR-DA-labeled neurons showing Fos-LI in lamina I and the outer part of lamina II (lamina IIo), and that both axonal varicosities with 5-HT-LI and those binding I-B4 were in close apposition to single neuronal profiles labeled with TMR-DA.
I-B4 Binding (binding) of in lamina associated with increased venous pressure under development
9) Confidence 0.01 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9214544 Disease Relevance 0.77 Pain Relevance 0.26
Sweat glands receive M2-receptor-immunoreactive fibres that express neither I-B4 binding nor substance P immunoreactivity, whereas blood vessels of the deeper dermis are innervated by I-B4-positive nerve fibres that are immunoreactive for M2 receptors and substance P.
I-B4 Binding (binding) of in nerve associated with substance p
10) Confidence 0.01 Published 2000 Journal Cell Tissue Res. Section Abstract Doc Link 10928269 Disease Relevance 0 Pain Relevance 0.35
The pattern of binding by the isolectin I-B4 from Griffonia simplicifolia to trigeminal ganglion neurons and the trigeminal nucleus caudalis has been investigated at the ultrastructural level in the rat.
I-B4 Binding (binding) of in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion neurons
11) Confidence 0.00 Published 1993 Journal Neuroscience Section Abstract Doc Link 8450967 Disease Relevance 0.40 Pain Relevance 0.11

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