INT5130

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2010
Negated 9
Speculated 12
Reported most in Abstract
Documents 139
Total Number 151
Disease Relevance 31.95
Pain Relevance 42.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
neurons 15
pituitary 13
plasma 5
anterior pituitary 4
uterine 3
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 707 100.00 Very High Very High Very High
agonist 680 100.00 Very High Very High Very High
narcan 242 100.00 Very High Very High Very High
Opioid 134 100.00 Very High Very High Very High
dexamethasone 89 100.00 Very High Very High Very High
opiate 39 100.00 Very High Very High Very High
Enkephalin 35 100.00 Very High Very High Very High
Dismenorea 29 100.00 Very High Very High Very High
gABA 28 100.00 Very High Very High Very High
addiction 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 42 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 211 99.92 Very High Very High Very High
Pain 86 99.66 Very High Very High Very High
Uterine Fibroids 13 99.40 Very High Very High Very High
Disease 85 99.36 Very High Very High Very High
Eating Disorder 11 99.20 Very High Very High Very High
Reprotox - General 3 541 99.16 Very High Very High Very High
Reprotox - General 1 181 99.16 Very High Very High Very High
Aging 41 99.16 Very High Very High Very High
Reprotox - General 2 40 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This neuroanatomical evidence may suggest that dynorphin has effects on GnRH regulation in humans as seen in other species.
Regulation (regulation) of GnRH associated with dynorphin
1) Confidence 0.62 Published 2009 Journal Reprod Sci Section Abstract Doc Link 19474285 Disease Relevance 0 Pain Relevance 0.34
Regulation of the gonadotropin-releasing hormone (GnRH) neuronal system: morphological aspects.
Regulation (Regulation) of GnRH in neuronal
2) Confidence 0.62 Published 1989 Journal J. Steroid Biochem. Section Title Doc Link 2513450 Disease Relevance 0 Pain Relevance 0.13
In particular, the dramatic effects of naloxone on GnRH pulse shape and interpulse GnRH levels raise the possibility that EOP play an important role in synchronizing the activity of the GnRH neurons involved in episodic GnRH secretion.
Regulation (effects) of GnRH in neurons associated with narcan
3) Confidence 0.61 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750462 Disease Relevance 0 Pain Relevance 0.41
In particular, the dramatic effects of naloxone on GnRH pulse shape and interpulse GnRH levels raise the possibility that EOP play an important role in synchronizing the activity of the GnRH neurons involved in episodic GnRH secretion.
Regulation (effects) of GnRH in neurons associated with narcan
4) Confidence 0.61 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750462 Disease Relevance 0 Pain Relevance 0.41
We, therefore, examined the effects of naloxone on GnRH pulse profiles in the hypophyseal portal blood of OVX and OVX+E ewes (n = 6/group).
Spec (examined) Regulation (effects) of GnRH in blood associated with narcan
5) Confidence 0.61 Published 1995 Journal Endocrinology Section Abstract Doc Link 7750462 Disease Relevance 0 Pain Relevance 0.40
[The role of the endogenous opioid system in the pathogenesis of polycystic ovary syndrome: the altered neuroendocrine regulation of GnRH-LH is corrected after clomiphene therapy].
Regulation (regulation) of GnRH in ovary associated with endogenous opioid and polycystic ovary syndrome
6) Confidence 0.60 Published 1992 Journal Minerva Endocrinol. Section Title Doc Link 1298870 Disease Relevance 1.12 Pain Relevance 0.27
However, significant negative correlations were observed between circulating levels of estradiol during the follicular phase and mu-receptor binding measures in the amygdala and hypothalamus, two regions thought to be involved in the regulation of GnRH pulsatility.
Regulation (regulation) of GnRH in amygdala associated with amygdala
7) Confidence 0.56 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9851799 Disease Relevance 0 Pain Relevance 0.43
In this study, we examined the effects of GnRH, FMRFamide, bicuculline, and enkephalin on horizontal cell activity in the white perch retina in an attempt to understand the synaptic inputs to the interplexiform cells.
Spec (examined) Regulation (effects) of GnRH in retina associated with enkephalin
8) Confidence 0.53 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 1682424 Disease Relevance 0 Pain Relevance 0.27
Thus, dysregulation of the GnRH releasing clock center in the nucleus arcuatus in the mediobasal hypothalamus is associated with altered central alpha-receptor activity which results in lowering of the set point of the central thermostat and the circulatory changes.
Regulation (dysregulation) of GnRH in hypothalamus
9) Confidence 0.53 Published 1994 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 7713285 Disease Relevance 0.36 Pain Relevance 0.31
Neither photoperiod nor T affected either mean GnRH or LH whereas naloxone (P < 0.01) increased both.
Neg (Neither) Regulation (affected) of GnRH associated with narcan
10) Confidence 0.46 Published 2000 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10701767 Disease Relevance 0 Pain Relevance 0.50
Investigations have proved the clinical importance of hypothalmic gonadotropin-releasing hormone (GnRH) and its agonistic and antagonistic analogs.
Regulation (importance) of GnRH
11) Confidence 0.45 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6130985 Disease Relevance 0.13 Pain Relevance 0.03
The role of GnRH agonists plus add-back therapy in the treatment of endometriosis.
Regulation (role) of GnRH associated with pain, endometriosis and agonist
12) Confidence 0.45 Published 1997 Journal Semin. Reprod. Endocrinol. Section Title Doc Link 9383836 Disease Relevance 0.65 Pain Relevance 0.51
The control of the gonadotrophin releasing hormone pulse generator in relation to opioid and nutritional cues.
Regulation (control) of gonadotrophin releasing hormone associated with opioid
13) Confidence 0.45 Published 1993 Journal Hum. Reprod. Section Title Doc Link 8276951 Disease Relevance 0 Pain Relevance 0.27
GnRH agonists are effective in the treatment of endometriosis, as well as other disorders, such as advanced prostrate cancer, precocious puberty and uterine leiomyomata.
Regulation (effective) of GnRH in uterine associated with endometriosis, uterine fibroids, precocious puberty, cancer and agonist
14) Confidence 0.45 Published 1998 Journal Depress Anxiety Section Abstract Doc Link 9706454 Disease Relevance 0.74 Pain Relevance 0.41
To elucidate the mechanism of hypogonadotropic hypogonadism in a patient with X-linked congenital adrenal hypoplasia, we studied the effects on serum LH and FSH of repeated iv administration of GnRH (400 micrograms, over 2 h, once a day, for 14 consecutive days), pulsatile sc administration of GnRH (5 micrograms every 90 min during days 1 approximately 56, 10 micrograms every 90 min during days 57 approximately 91) and an iv bolus injection of 10 mg of naloxone.
Regulation (effects) of GnRH associated with hypogonadotropic hypogonadism and narcan
15) Confidence 0.45 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3101337 Disease Relevance 0.17 Pain Relevance 0.04
To elucidate the mechanism of hypogonadotropic hypogonadism in a patient with X-linked congenital adrenal hypoplasia, we studied the effects on serum LH and FSH of repeated iv administration of GnRH (400 micrograms, over 2 h, once a day, for 14 consecutive days), pulsatile sc administration of GnRH (5 micrograms every 90 min during days 1 approximately 56, 10 micrograms every 90 min during days 57 approximately 91) and an iv bolus injection of 10 mg of naloxone.
Regulation (effects) of GnRH associated with hypogonadotropic hypogonadism and narcan
16) Confidence 0.45 Published 1987 Journal Acta Endocrinol. Section Abstract Doc Link 3101337 Disease Relevance 0.17 Pain Relevance 0.05
Side effects of GnRH analogue treatment in childhood.
Regulation (effects) of GnRH
17) Confidence 0.45 Published 2000 Journal J. Pediatr. Endocrinol. Metab. Section Title Doc Link 10969924 Disease Relevance 0.79 Pain Relevance 0.09
[Influence of GnRH analogue on the intensification of endometriosis symptoms and infertility treatment].
Regulation ([Influence) of GnRH associated with endometriosis, reprotox - general 3 and dismenorea
18) Confidence 0.45 Published 2004 Journal Wiad. Lek. Section Title Doc Link 15884262 Disease Relevance 1.19 Pain Relevance 0.83
These observations also suggest that the potential uses of GnRH analogs in the modulation of GnRH signaling and treatment of disease has yet to be fully realized.
Regulation (modulation) of GnRH associated with disease
19) Confidence 0.45 Published 2007 Journal Expert Opin Investig Drugs Section Abstract Doc Link 17970643 Disease Relevance 0.74 Pain Relevance 0.13
Moreover, the presence of GnRHR in a multitude of non-reproductive tissues including the recent discovery of GnRHR expression in the hippocampi and cortex of the human brain indicates that GnRH analogs such as leuprolide acetate may also act directly via tissue GnRHRs to modulate (brain) function.
Regulation (modulate) of GnRH in brain
20) Confidence 0.45 Published 2007 Journal Expert Opin Investig Drugs Section Abstract Doc Link 17970643 Disease Relevance 0.77 Pain Relevance 0.19

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