INT51307

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.00
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
spinal cord 2
neurons 2
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 8 100.00 Very High Very High Very High
Hyperalgesia 1 99.88 Very High Very High Very High
narcan 22 99.52 Very High Very High Very High
Spinal cord 3 96.60 Very High Very High Very High
substance P 1 94.76 High High
Substantia nigra 1 92.24 High High
Hippocampus 3 88.76 High High
Dorsal horn 1 88.12 High High
tricyclic antidepressant 1 84.80 Quite High
cINOD 1 83.56 Quite High
Disease Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
Hyperalgesia 1 99.88 Very High Very High Very High
Pressure And Volume Under Development 1 99.60 Very High Very High Very High
Disease 8 99.48 Very High Very High Very High
Nociception 2 99.10 Very High Very High Very High
Stress 4 95.48 Very High Very High Very High
INFLAMMATION 1 83.36 Quite High
Depression 1 75.72 Quite High
Inborn Genetic Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed that indomethacin significantly reduced nociception-related peripheral edema, hyperalgesia, and reversed the pain-evoked up-regulation of neurokinin (NK)-1 receptor and brain-derived neurotrophic factor (BDNF) gene expression in the spinal cord to levels not statistically different from controls.
Negative_regulation (reversed) of Positive_regulation (up-regulation) of neurokinin in spinal cord associated with nociception, pain, pressure and volume under development, hyperalgesia and spinal cord
1) Confidence 0.42 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16956981 Disease Relevance 1.45 Pain Relevance 1.45
We report on an HD phenocopy with selective loss of preprotachykinin (PPT) neurons, dysfunction of surviving PPT neurons, preservation of preproenkephalin (PPE) neurons within the striatum, and greater loss of immunohistochemical staining for substance P in terminals of striatal neurons projecting to the substantia nigra, than in those projecting to the internal pallidal segment.
Negative_regulation (loss) of Positive_regulation (dysfunction) of PPT in neurons associated with substantia nigra, disease and substance p
2) Confidence 0.10 Published 2002 Journal Mov. Disord. Section Abstract Doc Link 11921119 Disease Relevance 0.55 Pain Relevance 0.09
Naloxone 10(-7) M significantly reversed medium stimulation of NK activity, induced by 25 U/ml, in a group as a whole.
Negative_regulation (reversed) of Positive_regulation (induced) of NK associated with narcan
3) Confidence 0.07 Published 1993 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 7688780 Disease Relevance 0 Pain Relevance 0.64
Naloxone 10(-7) M significantly reversed medium stimulation of NK activity, induced by 25 U/ml, in a group as a whole.
Negative_regulation (reversed) of Positive_regulation (stimulation) of NK associated with narcan
4) Confidence 0.07 Published 1993 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 7688780 Disease Relevance 0 Pain Relevance 0.64

General Comments

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