INT5131

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Context Info
Confidence 0.78
First Reported 1983
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 109
Total Number 113
Disease Relevance 28.79
Pain Relevance 23.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
neurons 17
pituitary 16
follicle 3
hypothalamus 3
Plasma 2
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 417 100.00 Very High Very High Very High
antagonist 337 100.00 Very High Very High Very High
narcan 68 100.00 Very High Very High Very High
Opioid 59 100.00 Very High Very High Very High
amygdala 9 100.00 Very High Very High Very High
Dopamine 8 100.00 Very High Very High Very High
Morphine 11 99.96 Very High Very High Very High
Enkephalin 19 99.84 Very High Very High Very High
Somatostatin 18 99.74 Very High Very High Very High
alcohol 21 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reprotox - General 1 430 99.98 Very High Very High Very High
Cancer 133 99.98 Very High Very High Very High
Breast Cancer 99 99.98 Very High Very High Very High
Precocious Puberty 19 99.92 Very High Very High Very High
Stroke 5 99.86 Very High Very High Very High
Diabetes Mellitus 41 99.74 Very High Very High Very High
Ganglioneuroma 6 99.48 Very High Very High Very High
Endocrine Disease 3 99.48 Very High Very High Very High
Endometrial Cancer 4 99.46 Very High Very High Very High
Adenoma 4 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Numerous antagonistic analogs of GnRH have been synthesized and have shown some potential contraceptive effects in animal studies.
Gene_expression (synthesized) of GnRH
1) Confidence 0.78 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6130985 Disease Relevance 0.68 Pain Relevance 0.34
Native LHRH produced by the hypothalamus controls the secretion of follicle-stimulating hormone and luteinizing hormone by the pituitary gland, and hence gonadal steroid hormone production.
Gene_expression (produced) of LHRH in gonadal
2) Confidence 0.78 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138786 Disease Relevance 0.60 Pain Relevance 0.07
Trophoblast gonadotropic hormone human chorionic gonadotropin (hCG) and locally produced GnRH in human placenta are similar in structure and biological functions to luteinizing hormone and GnRH from hypothalamic-pituitary axis.
Gene_expression (produced) of GnRH in pituitary
3) Confidence 0.77 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8114013 Disease Relevance 0 Pain Relevance 0.41
These compounds have superior antitumor effects in cancers expressing GnRH receptors as compared with native doxorubicin and allow for a targeted cytotoxic chemotherapy of gynecologic and breast cancers.
Gene_expression (expressing) of GnRH in superior associated with cancer and breast cancer
4) Confidence 0.77 Published 2003 Journal Endocr. Relat. Cancer Section Abstract Doc Link 12790790 Disease Relevance 0.61 Pain Relevance 0.32
Approximately 80% of human ovarian and endometrial cancers and 50% of breast cancers express GnRH and its receptor as part of an autocrine regulatory system.
Gene_expression (express) of GnRH associated with breast cancer and endometrial cancer
5) Confidence 0.77 Published 2003 Journal Endocr. Relat. Cancer Section Abstract Doc Link 12790790 Disease Relevance 0.49 Pain Relevance 0.04
A variety of human cancers, including those of the breast, the ovary, and the endometrium, express GnRH receptors.
Gene_expression (express) of GnRH in endometrium associated with cancer
6) Confidence 0.76 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397531 Disease Relevance 1.03 Pain Relevance 0.12
GnRH receptors are expressed in the hypothalamic GnRH neurons suggesting that GnRH exerts an autocrine action [6,8].
Gene_expression (expressed) of GnRH in neurons
7) Confidence 0.76 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.23 Pain Relevance 0.25
Corticotropin-releasing factor (CRF) does interact with gonadotropin-releasing hormone (GnRH)-producing neurons, probably through an opioidergic pathway, suppressing gonadotropin secretion.
Gene_expression (producing) of GnRH in neurons
8) Confidence 0.75 Published 1990 Journal Int. J. Fertil. Section Abstract Doc Link 1968447 Disease Relevance 0.44 Pain Relevance 0.24
Opioids, primarily beta-endorphin, originating through CRF-independent mechanisms in the brain or even the pituitary may also inhibit GnRH production.
Gene_expression (production) of GnRH in pituitary associated with opioid
9) Confidence 0.75 Published 1990 Journal Int. J. Fertil. Section Abstract Doc Link 1968447 Disease Relevance 0.48 Pain Relevance 0.28
Corticotropin-releasing factor (CRF) does interact with gonadotropin-releasing hormone (GnRH)-producing neurons, probably through an opioidergic pathway, suppressing gonadotropin secretion.
Gene_expression (producing) of gonadotropin-releasing hormone in neurons
10) Confidence 0.75 Published 1990 Journal Int. J. Fertil. Section Abstract Doc Link 1968447 Disease Relevance 0.44 Pain Relevance 0.24
In particular, these peptides control the secretion of LH by inhibiting the activity of the hypothalamic neurons which produce GnRH.
Gene_expression (produce) of GnRH in neurons
11) Confidence 0.73 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.29
Through a feedback mechanism, they influence the synthesis and release of hypothalamic gonadotropin-releasing hormone (GnRH) and/or pituitary gonadotropic hormones (luteinizing hormone, LH, and follicle stimulating hormone, FSH).
Gene_expression (synthesis) of gonadotropin-releasing hormone in follicle
12) Confidence 0.73 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.20
Through a feedback mechanism, they influence the synthesis and release of hypothalamic gonadotropin-releasing hormone (GnRH) and/or pituitary gonadotropic hormones (luteinizing hormone, LH, and follicle stimulating hormone, FSH).
Gene_expression (synthesis) of GnRH in follicle
13) Confidence 0.73 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1359605 Disease Relevance 0 Pain Relevance 0.20
LHRH-IR elements were detected mainly in the medial basal hypothalamus, in the medial preoptic area and along the diagonal band of Broca.
Gene_expression (detected) of LHRH-IR in medial associated with urological neuroanatomy
14) Confidence 0.70 Published 2004 Journal Neuroscience Section Abstract Doc Link 14960353 Disease Relevance 0.18 Pain Relevance 0.07
Dynorphin immunoreactive fibers contact GnRH neurons in the human hypothalamus.
Gene_expression (neurons) of GnRH in hypothalamus associated with dynorphin
15) Confidence 0.68 Published 2009 Journal Reprod Sci Section Title Doc Link 19474285 Disease Relevance 0 Pain Relevance 0.39
In conclusion, dynorphin fibers form close contacts with GnRH neurons in humans.
Gene_expression (neurons) of GnRH in neurons associated with dynorphin
16) Confidence 0.68 Published 2009 Journal Reprod Sci Section Abstract Doc Link 19474285 Disease Relevance 0 Pain Relevance 0.35
For GnRH nonresponders, sequential treatment with human chorionic gonadotropin produced an 86.2% success rate.
Gene_expression (produced) of GnRH
17) Confidence 0.68 Published 1983 Journal Fertil. Steril. Section Abstract Doc Link 6130985 Disease Relevance 0.50 Pain Relevance 0.15
Recent, primarily immunocytochemical studies indicate that catecholaminergic, serotoninergic, GABA-ergic, opioid peptidergic, immunoreactive substance-P and corticotropin releasing factor-immunoreactive axons synapse on GnRH neurons.
Gene_expression (synapse) of GnRH in synapse associated with gaba and opioid
18) Confidence 0.68 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2513450 Disease Relevance 0 Pain Relevance 0.19
Direct connections of the GnRH neurons demonstrated so far does not exclude the possibility that these neurotransmitters or neuromodulators influence GnRH release also at other levels of the CNS.
Gene_expression (connections) of GnRH in neurons associated with neurotransmitter
19) Confidence 0.68 Published 1989 Journal J. Steroid Biochem. Section Abstract Doc Link 2513450 Disease Relevance 0 Pain Relevance 0.18
Clinical effects of luteinizing hormone-releasing hormone agonists
Gene_expression (agonists) of luteinizing hormone-releasing hormone associated with agonist
20) Confidence 0.67 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138786 Disease Relevance 0.51 Pain Relevance 0.26

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