INT51312

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Context Info
Confidence 0.46
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 9.41
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINA1) extracellular region (SERPINA1) proteinaceous extracellular matrix (SERPINA1)
Anatomy Link Frequency
plasma 4
liver 2
SERPINA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 344 99.92 Very High Very High Very High
Inflammation 40 99.12 Very High Very High Very High
rheumatoid arthritis 152 98.56 Very High Very High Very High
Osteoarthritis 144 95.20 Very High Very High Very High
palliative 2 83.44 Quite High
Bile 1 79.88 Quite High
imagery 1 54.64 Quite High
Arthritis 8 50.00 Quite Low
diclofenac 2 31.76 Quite Low
alcohol 3 5.08 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 105 100.00 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 21 100.00 Very High Very High Very High
Liver Failure 13 100.00 Very High Very High Very High
Low Back Pain 340 99.92 Very High Very High Very High
INFLAMMATION 43 99.12 Very High Very High Very High
Rheumatoid Arthritis 161 98.56 Very High Very High Very High
Stomach Cancer 3 97.68 Very High Very High Very High
Arthritis 12 95.96 Very High Very High Very High
Frailty 152 95.20 Very High Very High Very High
Necrosis 7 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was suggested that the increasing levels of A1AT and A1AChy during chemotherapy after radical surgery for gastric cancer may point to the progress of the disease.
Positive_regulation (increasing) of Gene_expression (levels) of A1AT associated with alpha-1-antitrypsin deficiency, disease and stomach cancer
1) Confidence 0.46 Published 1993 Journal Neoplasma Section Abstract Doc Link 7688868 Disease Relevance 0.86 Pain Relevance 0.16
Additionally, a significantly increased expression level of the alpha-1-antitrypsin (A1AT) precursor, which is an important plasma inhibitor of serine proteases, was detected in the synovial tissues of AS patients using a proteomic approach.
Positive_regulation (increased) of Gene_expression (expression) of antitrypsin in plasma associated with spinal inflammation and alpha-1-antitrypsin deficiency
2) Confidence 0.18 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.74 Pain Relevance 0.77
Additionally, a significantly increased expression level of the alpha-1-antitrypsin (A1AT) precursor, which is an important plasma inhibitor of serine proteases, was detected in the synovial tissues of AS patients using a proteomic approach.
Positive_regulation (increased) of Gene_expression (expression) of A1AT in plasma associated with spinal inflammation and alpha-1-antitrypsin deficiency
3) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.74 Pain Relevance 0.78
This study also detected increased expression of alpha-1-antitrypsin in the synovial tissues from AS patients, which is in agreement with other reports.


Positive_regulation (increased) of Gene_expression (expression) of antitrypsin associated with spinal inflammation
4) Confidence 0.12 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC3012668 Disease Relevance 1.62 Pain Relevance 0.91
Increased levels of the complex of immunoglobulin with A-alpha 1 antitrypsin have been detected in the serum of AS patients and were associated with a clinical index of the disease [9,10].
Positive_regulation (Increased) of Gene_expression (levels) of antitrypsin associated with spinal inflammation and disease
5) Confidence 0.12 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.87 Pain Relevance 0.89
Other causes of liver failure such as Wilson's disease and alpha-1-antitrypsin deficiency were excluded in these two patients.
Positive_regulation (causes) of Gene_expression (deficiency) of alpha-1-antitrypsin in liver associated with liver failure and disease
6) Confidence 0.06 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2329632 Disease Relevance 1.53 Pain Relevance 0.33
Pediatric MSC co-cultured with Huh-7 cells express more frequently albumin and alpha 1 anti-trypsin compared to adult MSC
Positive_regulation (frequently) of Gene_expression (express) of alpha 1 anti-trypsin
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.05 Pain Relevance 0

General Comments

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