INT51316

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Context Info
Confidence 0.51
First Reported 1993
Last Reported 2009
Negated 1
Speculated 3
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 4.23
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
blood 1
facets 1
amnion 1
fibroblasts 1
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 18 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
cINOD 4 100.00 Very High Very High Very High
Calcitonin gene-related peptide 2 100.00 Very High Very High Very High
antagonist 3 99.82 Very High Very High Very High
Catechol-O-methyltransferase 9 99.34 Very High Very High Very High
cytokine 65 98.08 Very High Very High Very High
Inflammation 106 96.60 Very High Very High Very High
depression 4 95.40 Very High Very High Very High
antidepressant 3 93.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 117 100.00 Very High Very High Very High
Cataract 4 98.72 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 98.44 Very High Very High Very High
Ocular Hypertension 14 98.16 Very High Very High Very High
Depression 7 95.40 Very High Very High Very High
Natriuresis 1 88.48 High High
Pressure And Volume Under Development 1 82.08 Quite High
Weight Gain 1 80.72 Quite High
Affective Disorder 24 78.40 Quite High
Eye Disease 6 72.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: We examined the effect of 3 commonly used nonsteroidal antiinflammatory drugs (NSAID), indomethacin, naproxen and tiaprofenic acid, and a prostaglandin E1 analog, misoprostol, on the glucocorticoid receptor level in synovial fibroblasts.
Spec (examined) Regulation (effect) of glucocorticoid receptor in fibroblasts associated with inflammation and cinod
1) Confidence 0.51 Published 1994 Journal J. Rheumatol. Section Abstract Doc Link 7799361 Disease Relevance 0.17 Pain Relevance 0.10
Modulation of the human glucocorticoid receptor function by antidepressive compounds.
Regulation (Modulation) of glucocorticoid receptor
2) Confidence 0.44 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12757900 Disease Relevance 0.19 Pain Relevance 0.34
Briefly, most of these SNPs are intronic or intergenic except that rs4633 (COMT), rs1801291 (MAOA), and rs6196 (NR3C1) are synonymous coding changes [8].
Regulation (changes) of NR3C1 associated with catechol-o-methyltransferase
3) Confidence 0.27 Published 2009 Journal J Transl Med Section Body Doc Link PMC2765429 Disease Relevance 0.19 Pain Relevance 0.13
Such tests are more sensitive as they assess facets of the HPA axis which are considered to be primary causal factors, namely dysregulation of hypothalamic drive (Holsboer 2002) and reduced glucocorticoid receptor (GR) feedback (McQuade and Young 2000; Pariante and Miller 2001).
Regulation (dysregulation) of glucocorticoid receptor in facets
4) Confidence 0.23 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.54 Pain Relevance 0.13
Paradox of glucocorticoid-induced cytosolic phospholipase A2 group IVA messenger RNA expression involves glucocorticoid receptor binding to the promoter in human amnion fibroblasts.
Regulation (involves) of glucocorticoid receptor in amnion associated with cytokine
5) Confidence 0.22 Published 2008 Journal Biol. Reprod. Section Title Doc Link 17901074 Disease Relevance 0.22 Pain Relevance 0.21
Selective glucocorticoid receptor agonists (SEGRAs) represent a set of molecules that preferentially regulate glucocorticoid receptor-mediated gene expression via transrepression and carry out glucocorticoid-like anti-inflammatory activities.
Spec (like) Regulation (regulate) of glucocorticoid receptor associated with inflammation and agonist
6) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.25 Pain Relevance 0.38
Selective glucocorticoid receptor agonists (SEGRAs) represent a set of molecules that preferentially regulate glucocorticoid receptor-mediated gene expression via transrepression and carry out glucocorticoid-like anti-inflammatory activities.
Spec (like) Regulation (regulate) of glucocorticoid receptor associated with inflammation and agonist
7) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.29 Pain Relevance 0.39
In rats, rabbits and in man, it is a PR-agonist and an MCR- and androgen-R antagonist with no effect on the glucocorticoid-R and the estrogen-R.
Neg (no) Regulation (effect) of glucocorticoid-R associated with antagonist and agonist
8) Confidence 0.02 Published 2004 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 15134826 Disease Relevance 0.38 Pain Relevance 0.14
The effects of systemically-administered human alpha calcitonin gene-related peptide (h.alpha CGRP), substance P and the selective neurokinin receptor agonists, GR73632 (NK1) and GR64349 (NK2) on cerebral blood flow (CBF) were studied in anaesthetized guinea-pigs using a laser-Doppler flowmeter. h.alpha CGRP (0.1 and 0.3 nmol/kg), substance P (0.03-1.0 nmol/kg), GR73632 (0.03-0.3 nmol/kg) and GR64349 (0.3 nmol/kg) each, following intra-carotid artery injection, reduced transiently (< 5 min) blood pressure and CBF.
Regulation (effects) of GR64349 in blood associated with agonist, substance p and calcitonin gene-related peptide
9) Confidence 0.01 Published 1993 Journal Neuropeptides Section Abstract Doc Link 7688875 Disease Relevance 0 Pain Relevance 0.27

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