INT5132

Context Info Confidence 0.08 First Reported 1990 Last Reported 1992 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0.52

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1) cell-cell signaling (GNRH1)

Anatomy Link Frequency Pituitary 1 GNRH1 (Homo sapiens) Lhb (Mus musculus)

Pain Link Frequency Relevance Heat narcan 6 99.38 transdermal 3 97.12 Endogenous opioid 3 84.96 Opioid 3 50.00

Disease Link Frequency Relevance Heat Weight Loss 2 50.00 Eating Disorder 2 50.00 Body Weight 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pituitary LH response to exogenous GnRH during weight recovery does not accurately predict the outcome of the disease regarding reinitiation of menstrual cycles; however, it might be an indicator that the normal function of the hypothalamic-pituitary axis is being restored.

GnRH Regulation (response) of LH in Pituitary

1) Confidence 0.08 Published 1992 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 1286522 Disease Relevance 0 Pain Relevance 0

In untreated postmenopausal women, two different doses of naloxone infusion failed to modify the LH and FSH responses to GnRH stimulation.

GnRH Regulation (responses) of LH associated with narcan

2) Confidence 0.05 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2105330 Disease Relevance 0 Pain Relevance 0.52

General Comments

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