INT51340

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Context Info
Confidence 0.22
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.38
Pain Relevance 0.36

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extracellular space (Vtn) proteinaceous extracellular matrix (Vtn) extracellular matrix organization (Vtn)
Vtn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 1 99.02 Very High Very High Very High
palliative 3 94.68 High High
Disease Link Frequency Relevance Heat
Breast Cancer 9 99.78 Very High Very High Very High
Cancer 6 97.12 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 3 90.24 High High
Adhesions 3 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SP-40,40 bound to beta-endorphin via C-terminal non-opioid portion of beta-endorphin as well as S-protein (vitronectin) bound.
vitronectin Binding (bound) of associated with opioid
1) Confidence 0.22 Published 1993 Journal Biol. Pharm. Bull. Section Abstract Doc Link 7689889 Disease Relevance 0 Pain Relevance 0.10
We identified two aptamers, WT-15 and SM-20, that disrupt the interactions between PAI-1 and heparin, as well as PAI-1 and vitronectin, without affecting the antiprotease activity of PAI-1.
vitronectin Binding (interactions) of
2) Confidence 0.04 Published 2009 Journal Oligonucleotides Section Abstract Doc Link 19284310 Disease Relevance 0.48 Pain Relevance 0.08
PAI-1 competes with integrins and the urokinase plasminogen activator receptor on the surface of breast cancer cells for binding to vitronectin.
vitronectin Binding (binding) of associated with breast cancer
3) Confidence 0.04 Published 2009 Journal Oligonucleotides Section Abstract Doc Link 19284310 Disease Relevance 0.42 Pain Relevance 0.09
For this reason, we sought to isolate RNA aptamers that disrupt the interaction between PAI-1 and vitronectin.
vitronectin Binding (interaction) of
4) Confidence 0.03 Published 2009 Journal Oligonucleotides Section Abstract Doc Link 19284310 Disease Relevance 0.47 Pain Relevance 0.09

General Comments

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