INT5135

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 106
Total Number 108
Disease Relevance 36.63
Pain Relevance 27.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1)
cell-cell signaling (GNRH1)
Anatomy Link Frequency
pituitary 17
plasma 4
gonadal 4
neurons 4
follicle 3
GNRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 182 100.00 Very High Very High Very High
antagonist 109 100.00 Very High Very High Very High
Pain 51 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
narcan 132 99.98 Very High Very High Very High
Endogenous opioid 48 99.98 Very High Very High Very High
Opioid 49 99.80 Very High Very High Very High
tetrodotoxin 5 99.78 Very High Very High Very High
Analgesic 3 99.74 Very High Very High Very High
dexamethasone 13 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 55 100.00 Very High Very High Very High
Hypogonadotropic Hypogonadism 45 100.00 Very High Very High Very High
Breast Cancer 17 100.00 Very High Very High Very High
Breast Disease 8 100.00 Very High Very High Very High
Pituitary Apoplexy 5 99.98 Very High Very High Very High
Endometriosis (extended) 129 99.82 Very High Very High Very High
Reprotox - General 1 233 99.76 Very High Very High Very High
Stress 124 99.68 Very High Very High Very High
Delayed Puberty 16 99.68 Very High Very High Very High
Disease 105 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Testosterone acts at the hypothalamus, perhaps through opioid mechanisms, to inhibit GnRH pulse frequency and to maintain a regular pattern of pulses occurring approximately every 90-110 min in adult males.
Negative_regulation (inhibit) of GnRH in hypothalamus associated with opioid
1) Confidence 0.58 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0.19
The treatment of precocious puberty is probably the perfect indication for GnRH agonist suppression.
Negative_regulation (suppression) of GnRH associated with precocious puberty and agonist
2) Confidence 0.58 Published 1989 Journal Clin Obstet Gynecol Section Abstract Doc Link 2673600 Disease Relevance 0.52 Pain Relevance 0.57
In order to assess a possible influence of endogenous opioids upon gonadotrophin secretion in women, we examined the effects of i.v. administration of 10 mg naloxone, a specific opiate antagonist, in ten normal menstruating women, in thirteen women with amenorrhoea and/or hyperprolactinaemia and in two women with putative deficiency of gonadotrophin-releasing hormone (GnRH).
Negative_regulation (deficiency) of gonadotrophin-releasing hormone associated with galactorrhea, antagonist, narcan, endogenous opioid, opiate and reprotox - general 1
3) Confidence 0.58 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6790206 Disease Relevance 0.20 Pain Relevance 0.37
In order to assess a possible influence of endogenous opioids upon gonadotrophin secretion in women, we examined the effects of i.v. administration of 10 mg naloxone, a specific opiate antagonist, in ten normal menstruating women, in thirteen women with amenorrhoea and/or hyperprolactinaemia and in two women with putative deficiency of gonadotrophin-releasing hormone (GnRH).
Negative_regulation (deficiency) of GnRH associated with galactorrhea, antagonist, narcan, endogenous opioid, opiate and reprotox - general 1
4) Confidence 0.58 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6790206 Disease Relevance 0.20 Pain Relevance 0.37
Mounting evidence suggests that GnRH agonist suppression of serum gonadotropins may also be important in many of the clinical applications described above.
Negative_regulation (suppression) of GnRH associated with agonist
5) Confidence 0.58 Published 2007 Journal Expert Opin Investig Drugs Section Abstract Doc Link 17970643 Disease Relevance 0.85 Pain Relevance 0.22
Gonadotropin-releasing hormone analogues (GnRH agonists) cause pituitary desensitization by downregulation of GnRH receptors, decrease gonadal steroid production, and reduce uterine volume in women with leiomyomas.
Negative_regulation (downregulation) of GnRH in uterine associated with uterine fibroids and agonist
6) Confidence 0.57 Published 1993 Journal Hum. Pathol. Section Abstract Doc Link 8406417 Disease Relevance 0.53 Pain Relevance 0.20
In conclusion, these results demonstrate that: (1) in mid-anestrous ewes EOPs, besides DA, are involved in the inhibition of the GnRH/LH axis; (2) brief administration of melatonin in long-photoperiod-inhibited ewes suppresses LH pulse frequency after the elimination of the inhibitory DA input, but seems to not affect LH release following opiate receptor blockade.
Negative_regulation (inhibition) of GnRH associated with opiate
7) Confidence 0.57 Published 2004 Journal Anim. Reprod. Sci. Section Abstract Doc Link 14998651 Disease Relevance 0 Pain Relevance 0.20
The purpose of the study was to evaluate the efficacy and safety of a sequential regimen of estrogen-progestin addition to GnRH agonist suppression in ovarian hyperandrogenism.
Negative_regulation (suppression) of GnRH associated with agonist and hyperandrogenism
8) Confidence 0.53 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7989480 Disease Relevance 0.27 Pain Relevance 0.17
Increased endogenous opioid inhibition of the hypothalamic GnRH pulse generator resulting in insufficient stimulation of the pituitary gonadotroph has been proposed as a possible mechanism.
Negative_regulation (inhibition) of GnRH in gonadotroph associated with endogenous opioid
9) Confidence 0.53 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7922600 Disease Relevance 0.63 Pain Relevance 0.37
In patients who responded to the administration of naltrexone, there was a dramatic increase in the amplitude and frequency of gonadotrophin pulses, reflecting disinhibition of the hypothalamic gonadotrophin-releasing hormone (GnRH) pulse generator.
Negative_regulation (disinhibition) of gonadotrophin-releasing hormone
10) Confidence 0.53 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8473447 Disease Relevance 0.40 Pain Relevance 0.28
Naloxone decreased GnRH IPI (P < 0.01).
Negative_regulation (decreased) of GnRH associated with narcan
11) Confidence 0.44 Published 2000 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10701767 Disease Relevance 0 Pain Relevance 0.61
However, the GnRH agonists provoke suppress on E2, which lead to transient bones demineralization.
Negative_regulation (suppress) of GnRH associated with agonist
12) Confidence 0.43 Published 2000 Journal Akush Ginekol (Sofiia) Section Abstract Doc Link 11288628 Disease Relevance 0.44 Pain Relevance 0.32
The addition of morphine, methionine-enkephalin, or UP50, 488H which preferentially bind mu-, delta-, and kappa-opiate receptors, respectively, did not decrease basal irGnRH release from cultured human placental cells.
Neg (not) Negative_regulation (decrease) of irGnRH associated with opiate, enkephalin and morphine
13) Confidence 0.43 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.70
Gonadotrophin-releasing hormone (GnRH) agonists are the most widely used androgen deprivation therapy, but do have some drawbacks.
Negative_regulation (deprivation) of Gonadotrophin-releasing hormone associated with agonist
14) Confidence 0.43 Published 2009 Journal Neuroendocrinology Section Abstract Doc Link 19602868 Disease Relevance 0.50 Pain Relevance 0.19
Gonadotrophin-releasing hormone (GnRH) agonists are the most widely used androgen deprivation therapy, but do have some drawbacks.
Negative_regulation (deprivation) of GnRH associated with agonist
15) Confidence 0.43 Published 2009 Journal Neuroendocrinology Section Abstract Doc Link 19602868 Disease Relevance 0.50 Pain Relevance 0.19
Progesterone also acutely inhibits GnRH pulse frequency via a non-EOP mechanism, as naloxone does not block the rapid effects of this steroid.
Negative_regulation (inhibits) of GnRH associated with narcan
16) Confidence 0.42 Published 2002 Journal Reprod. Suppl. Section Abstract Doc Link 12698972 Disease Relevance 0 Pain Relevance 0.23
The most well characterized action is inhibition of GnRH pulse amplitude, which is probably mediated by noradrenergic neurones.
Negative_regulation (inhibition) of GnRH
17) Confidence 0.42 Published 2002 Journal Reprod. Suppl. Section Abstract Doc Link 12698972 Disease Relevance 0 Pain Relevance 0.22
Endogenous opioids exert a tonic inhibitory effect on GnRH release; this opioid inhibition is dependent upon the gonadal steroid milieu, and may play a role in the initiation of the mid-cycle luteinizing hormone surge.
Negative_regulation (effect) of GnRH in gonadal associated with endogenous opioid and opioid
18) Confidence 0.42 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8276951 Disease Relevance 0 Pain Relevance 0.27
Pain was attributed to the presence of these residual ovaries if there was an adnexal mass--or the pain improved following ovarian suppression with a GnRH analogue.
Negative_regulation (suppression) of GnRH in ovaries associated with pain
19) Confidence 0.42 Published 2007 Journal J Obstet Gynaecol Section Abstract Doc Link 17999301 Disease Relevance 0.45 Pain Relevance 0.45
Effectiveness of combined GnRH analogue plus raloxifene administration in the treatment of uterine leiomyomas: a prospective, randomized, single-blind, placebo-controlled clinical trial.
Negative_regulation (Effectiveness) of GnRH in uterine associated with pain and uterine fibroids
20) Confidence 0.42 Published 2002 Journal Hum. Reprod. Section Title Doc Link 12456626 Disease Relevance 0.36 Pain Relevance 0.10

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