INT5136

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 71
Total Number 71
Disease Relevance 11.22
Pain Relevance 51.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
plasma 3
pallidum 3
NG108-15 3
putamen 3
ventral 2
PDYN (Homo sapiens)
PDYN - S2L (1)
Pain Link Frequency Relevance Heat
Enkephalin 307 100.00 Very High Very High Very High
Dynorphin 155 100.00 Very High Very High Very High
Morphine 60 100.00 Very High Very High Very High
MU agonist 8 100.00 Very High Very High Very High
Serotonin 2 100.00 Very High Very High Very High
bradykinin 2 100.00 Very High Very High Very High
Potency 8 99.98 Very High Very High Very High
anesthesia 22 99.96 Very High Very High Very High
Cholecystokinin 1 99.96 Very High Very High Very High
narcan 42 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 5 100.00 Very High Very High Very High
Uremia 4 99.84 Very High Very High Very High
Dyspnea 6 99.54 Very High Very High Very High
Hypersensitivity 4 99.40 Very High Very High Very High
Bradycardia 1 99.32 Very High Very High Very High
Parkinson's Disease 18 98.88 Very High Very High Very High
Arrhythmias 2 Under Development 4 98.38 Very High Very High Very High
Malignant Tumors Of Salivary Glands 4 98.36 Very High Very High Very High
Cold Sores 5 97.96 Very High Very High Very High
Aging 5 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most interestingly, activation of U-937 cells with lipopolysaccharide (LPS) led to a decrease in PDYN mRNA levels.
Negative_regulation (decrease) of PDYN mRNA in U-937
1) Confidence 0.59 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16483672 Disease Relevance 0 Pain Relevance 0.15
Results from transient transfections and dual luciferase assays showed that PDYN gene promoter activity was decreased by LPS treatment.
Negative_regulation (decreased) of PDYN gene
2) Confidence 0.59 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16483672 Disease Relevance 0 Pain Relevance 0.11
However, AR caused a significant decrease of the dynorphin levels in spinal cord.
Negative_regulation (decrease) of dynorphin in spinal cord associated with dynorphin and spinal cord
3) Confidence 0.57 Published 2006 Journal In Vivo Section Abstract Doc Link 16900785 Disease Relevance 0.93 Pain Relevance 0.72
Ventricular fibrillation, caused by the occlusion of the anterior descending coronary artery, results in leu-enkephalin level decrease in ischemic and non-ischemic zones of myocardium.
Negative_regulation (decrease) of leu-enkephalin in myocardium associated with arrhythmias 2 under development and enkephalin
4) Confidence 0.57 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 2847826 Disease Relevance 0.34 Pain Relevance 0.34
Although these cells remain histologically intact, the decrease in dynorphin level precedes and continues during the delayed loss of hippocampal CA1 neurons characteristic of this model and further defines the selective vulnerability of hippocampal circuitry following ischemia.
Negative_regulation (decrease) of dynorphin in neurons associated with dynorphin and ischemia
5) Confidence 0.57 Published 1987 Journal Stroke Section Abstract Doc Link 2885947 Disease Relevance 0.27 Pain Relevance 0.83
A significant reduction in Leu5-enkephalin and Met5-enkephalin levels had been previously observed in the pallidum and putamen whereas only Met5-enkephalin concentrations were decreased in the substantia nigra of parkinsonian brains.
Negative_regulation (reduction) of Leu5-enkephalin in pallidum associated with parkinson's disease, substantia nigra and enkephalin
6) Confidence 0.55 Published 1985 Journal Brain Res. Section Abstract Doc Link 2864101 Disease Relevance 0.26 Pain Relevance 0.50
The reduction in heterozygosity at PDYN (Figure 4C) is even more extreme (p < 0.003 for Italy and India, p < 0.006 for Ethiopia, p = 0.016 for China, and p = 0.072 for Papua New Guinea).
Negative_regulation (reduction) of PDYN
7) Confidence 0.51 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1283535 Disease Relevance 0 Pain Relevance 0
The loss of the PDYN gene in chicken is unexpected since it is present in mammals, fishes and in the lizard Anolis carolinensis.
Negative_regulation (loss) of PDYN
8) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2865548 Disease Relevance 0 Pain Relevance 0.27
Thus the inhibitory effect of leu-enkephalin is due mainly to an action on myenteric ganglia as well as on axon terminals of the myenteric plexus subserving the peristaltic reflex.
Negative_regulation (effect) of leu-enkephalin in ganglia associated with enkephalin
9) Confidence 0.44 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 3591348 Disease Relevance 0 Pain Relevance 0.89
In the presence of proteolysis inhibitors, hydrolysis of Leu-enkephalin and association to cells of its radioactive label are reduced.
Negative_regulation (reduced) of Leu-enkephalin associated with enkephalin
10) Confidence 0.43 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8014025 Disease Relevance 0 Pain Relevance 0.44
Inhibition of dynorphin converting enzymes from human spinal cord by N-peptidyl-O-acyl hydroxylamines.
Negative_regulation (Inhibition) of dynorphin in spinal cord associated with dynorphin and spinal cord
11) Confidence 0.42 Published 1993 Journal J. Biochem. Section Title Doc Link 8113215 Disease Relevance 0 Pain Relevance 0.27
On the other hand, the hyperalgesia, as a consequence of peripheral inflammation induced by a variety of agents, is associated with increased dynorphin expression [18-20], and opioid receptor antagonists reversed the decrease in dynorphin level induced by paracetamol [21].
Negative_regulation (decrease) of dynorphin associated with paracetamol, hyperalgesia, dynorphin, inflammation, antagonist and opioid receptor
12) Confidence 0.42 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000619 Disease Relevance 0.32 Pain Relevance 1.74
Identification of bikunin as an endogenous inhibitor of dynorphin convertase in human cerebrospinal fluid.
Negative_regulation (inhibitor) of dynorphin in cerebrospinal fluid associated with dynorphin
13) Confidence 0.42 Published 2006 Journal FEBS J. Section Title Doc Link 17087727 Disease Relevance 0 Pain Relevance 0.49
The hypothalamic isolation prevented both the inhibitory effect of Leu-enkephalin on the rumen motility and the drug induced psychosedative action.
Negative_regulation (inhibitory) of Leu-enkephalin associated with enkephalin
14) Confidence 0.42 Published 1992 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 1414089 Disease Relevance 0 Pain Relevance 0.55
However the hypothalamic isolation did not prevent Leu-enkephalin induced inhibition of the mean amplitude of rumen contractions, but this inhibition was not significant (NS).
Negative_regulation (prevent) of Leu-enkephalin associated with enkephalin
15) Confidence 0.42 Published 1992 Journal Zentralbl Veterinarmed A Section Abstract Doc Link 1414089 Disease Relevance 0 Pain Relevance 0.69
By immunocytochemistry, the NE cells revealed the presence of serotonin, met-enkephalin, and leu-enkephalin.
Negative_regulation (presence) of leu-enkephalin associated with enkephalin and serotonin
16) Confidence 0.41 Published 1992 Journal Anat. Rec. Section Abstract Doc Link 1443667 Disease Relevance 0 Pain Relevance 0.25
The most striking effect was on dynorphin A immunoreactivity, which was reduced by 30-40% as early as 1 hour after recirculation and remained at 50% of the control level for at least 1 week.
Negative_regulation (reduced) of dynorphin associated with dynorphin
17) Confidence 0.41 Published 1987 Journal Stroke Section Abstract Doc Link 2885947 Disease Relevance 0.20 Pain Relevance 0.66
In the present work, by studying co-localization of c-Fos immunoreactivity and preproenkephalin and preprodynorphin transcripts, we show that co-administration of the A1 receptor agonist CPA and the A2A receptor agonist CGS 21680 increases the striatal expression of c-fos in GABAergic enkephalinergic but not in GABAergic dynorphinergic neurons.
Negative_regulation (studying) of preprodynorphin in CPA associated with gabaergic and agonist
18) Confidence 0.41 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16452987 Disease Relevance 0 Pain Relevance 0.47
A significant reduction in Leu5-enkephalin and Met5-enkephalin levels had been previously observed in the pallidum and putamen whereas only Met5-enkephalin concentrations were decreased in the substantia nigra of parkinsonian brains.
Negative_regulation (reduction) of Met5-enkephalin in pallidum associated with parkinson's disease, substantia nigra and enkephalin
19) Confidence 0.40 Published 1985 Journal Brain Res. Section Abstract Doc Link 2864101 Disease Relevance 0.26 Pain Relevance 0.50
A significant reduction in Leu5-enkephalin and Met5-enkephalin levels had been previously observed in the pallidum and putamen whereas only Met5-enkephalin concentrations were decreased in the substantia nigra of parkinsonian brains.
Negative_regulation (decreased) of Met5-enkephalin in pallidum associated with parkinson's disease, substantia nigra and enkephalin
20) Confidence 0.40 Published 1985 Journal Brain Res. Section Abstract Doc Link 2864101 Disease Relevance 0.26 Pain Relevance 0.50

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