INT51392

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Context Info
Confidence 0.27
First Reported 1993
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 14.75
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
macrophages 5
monocytes 1
fat 1
esophagus 1
myeloid cell 1
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 19 100.00 Very High Very High Very High
allodynia 4 100.00 Very High Very High Very High
Eae 4 99.74 Very High Very High Very High
Nerve growth factor 3 99.30 Very High Very High Very High
metalloproteinase 258 98.64 Very High Very High Very High
Dorsal horn 3 98.64 Very High Very High Very High
Inflammation 280 98.44 Very High Very High Very High
cINOD 7 94.64 High High
qutenza 8 94.24 High High
Pain 4 93.52 High High
Disease Link Frequency Relevance Heat
Obesity 1072 100.00 Very High Very High Very High
Neuropathic Pain 5 100.00 Very High Very High Very High
Injury 7 99.74 Very High Very High Very High
Insulin Resistance 283 99.62 Very High Very High Very High
Cancer 152 98.68 Very High Very High Very High
INFLAMMATION 314 98.44 Very High Very High Very High
Targeted Disruption 113 98.08 Very High Very High Very High
Hyperinsulinism 38 97.68 Very High Very High Very High
Dna Damage 10 97.08 Very High Very High Very High
Disease 29 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we could directly demonstrate that siRNA-mediated ablation of MMP-9 drastically impairs macrophage transmigration through a gelatin matrix and that this can be phenocopied by loss of the insulin receptor.
Negative_regulation (loss) of insulin receptor in macrophage associated with metalloproteinase
1) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.94 Pain Relevance 0.35
To this end, we have generated and analyzed mice with inactivation of the insulin receptor specifically in myeloid cell-derived, inflammatory cells.
Spec (analyzed) Negative_regulation (inactivation) of insulin receptor in myeloid cell associated with inflammation
2) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.31 Pain Relevance 0.32
To determine the role of insulin action in macrophages and monocytes in obesity-associated insulin resistance, we conditionally inactivated the insulin receptor (IR) gene in myeloid lineage cells in mice (IR?
Negative_regulation (inactivated) of IR in monocytes associated with obesity and insulin resistance
3) Confidence 0.26 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.32 Pain Relevance 0.17
Importantly, IR disruption in macrophages not only affected MMP-9 expression, but also translated into reduced MMP-9 activity.
Negative_regulation (disruption) of IR in macrophages associated with metalloproteinase
4) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.34 Pain Relevance 0.49
In summary, these experiments indicate that the major improvement in glucose metabolism of obese IR?
Negative_regulation (metabolism) of IR associated with obesity
5) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.95 Pain Relevance 0.11
Another question is why reduced macrophage accumulation in obese IR?
Negative_regulation (reduced) of IR in macrophage associated with obesity
6) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.26 Pain Relevance 0.04
However, in line with the reduced mRNA expression of macrophage marker genes, immunohistochemical analysis of infiltrating, activated macrophages demonstrated a striking reduction of Mac-2-positive cells in WAT of diet-induced obese IR?
Negative_regulation (reduction) of IR in macrophages associated with obesity
7) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.14 Pain Relevance 0
Our data revealed that ethanol challenge downregulated insulin receptor ?
Negative_regulation (downregulated) of insulin receptor
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.09 Pain Relevance 0.04
Treatment with both celecoxib and an ACE inhibitor/ARB decreased IGF-IR expression levels in inoculated tumor cells.
Negative_regulation (decreased) of IGF-IR associated with cancer
9) Confidence 0.19 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.62 Pain Relevance 0.49
Consistent with the OGTT data, acute ethanol treatment significantly downregulated the insulin postreceptor signaling molecule PPAR-?
Negative_regulation (downregulated) of insulin postreceptor
10) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.08 Pain Relevance 0.04
Previously, we showed that stable knockdown of STAT1 in IR-resistant and IFN?
Negative_regulation (knockdown) of IR
11) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.86 Pain Relevance 0
Berberine, as a natural plant alkaloid isolated from the Coptis chinens, has been noted for its potential glucose lowering effect[15].

• Influence on insulin resistance(IR) and serum insulin: JQJT tablets can improve the insulin resistance caused by Hydrocortisone and decrease the serum insulin in mice[16]. • Influence on immune function: JQJT tablets can improve immune function and protect thymus gland atrophy of mice [16].


Negative_regulation (decrease) of insulin associated with frailty and insulin resistance
12) Confidence 0.15 Published 2010 Journal Trials Section Body Doc Link PMC2842259 Disease Relevance 0.71 Pain Relevance 0.04
We have shown that re-expression of MBNL1 is sufficient to rescue the IR splice defects in DM1 patient cells [46], [47].
Negative_regulation (defects) of IR
13) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.35 Pain Relevance 0
These fat insulin receptor knockout (FIRKO) mice express a mutated insulin receptor gene in adipose tissue only and exhibit 85–90% reduction in the insulin receptor protein in fat tissues.
Negative_regulation (reduction) of insulin receptor in fat associated with targeted disruption and obesity
14) Confidence 0.13 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.91 Pain Relevance 0
The heterozygous mice (IR mutants) showed suppressed kinase activity of the insulin receptor with normal growth.
Negative_regulation (suppressed) of insulin receptor
15) Confidence 0.13 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.97 Pain Relevance 0.04
To determine the role of insulin action in macrophages and monocytes in obesity-associated insulin resistance, we conditionally inactivated the insulin receptor (IR) gene in myeloid lineage cells in mice (IR?
Negative_regulation (inactivated) of IR in macrophages associated with obesity and insulin resistance
16) Confidence 0.09 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.32 Pain Relevance 0.17
However, the microarray results indicate that the downstream insulin receptor, as well as expression of endothelial NO synthase (eNos) was suppressed by the HF diet, what agree with the recent knowledge [34].
Negative_regulation (suppressed) of insulin receptor
17) Confidence 0.08 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.29 Pain Relevance 0.07
This was accompanied by a 43.3% decrease of IR-SP content in the mucosa of the distal esophagus of desensitized animals.
Negative_regulation (decrease) of IR-SP in esophagus associated with substance p
18) Confidence 0.07 Published 1993 Journal J. Surg. Res. Section Abstract Doc Link 7692139 Disease Relevance 0 Pain Relevance 0.93
Also, the phylogenetically related insulin receptor (IR) on pancreatic ?
Negative_regulation (related) of insulin
19) Confidence 0.05 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.18 Pain Relevance 0.07
We first explored the possible influence of demographic and clinical variables, including age, sex, BMI, total dosage of gliclazide during the 8 weeks of treatment, and baseline HOMA-B and HOMA-IR, on percent decrease in FPG after 8 weeks of gliclazide therapy.
Spec (possible) Negative_regulation (decrease) of HOMA-IR
20) Confidence 0.03 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2551631 Disease Relevance 0 Pain Relevance 0

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