INT514

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Context Info
Confidence 0.53
First Reported 1979
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.23
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adrb2) signal transduction (Adrb2) plasma membrane (Adrb2)
nucleus (Adrb2) cytoplasm (Adrb2) signal transducer activity (Adrb2)
Anatomy Link Frequency
tail 1
Adrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 3 100.00 Very High Very High Very High
antinociception 3 99.98 Very High Very High Very High
agonist 1 99.96 Very High Very High Very High
Clonidine 2 99.56 Very High Very High Very High
Intracerebroventricular 1 99.48 Very High Very High Very High
opiate 3 99.30 Very High Very High Very High
Analgesic 4 98.98 Very High Very High Very High
Morphine 8 98.50 Very High Very High Very High
tail-flick 1 97.88 Very High Very High Very High
methadone 1 82.40 Quite High
Disease Link Frequency Relevance Heat
Vomiting 2 83.00 Quite High
Convulsion 1 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mouse, morphine appears to stimulate presynaptic opiate receptors that modify exclusively beta - adrenoceptor-mediated cyclic AMP production.
Gene_expression (production) of beta - adrenoceptor associated with opiate and morphine
1) Confidence 0.53 Published 1981 Journal J. Neurosci. Res. Section Abstract Doc Link 6278156 Disease Relevance 0 Pain Relevance 0.92
The present study examined the generality of this conclusion by measuring the effect of Glib on supraspinal (intracerebroventricular; i.c.v.) antinociception produced by representative mu-opioids and the non-opioids pilocarpine and two alpha 2-adrenoceptor agonists (clonidine and tizanidine) using the mouse tail-flick test.
Gene_expression (produced) of 2-adrenoceptor in tail associated with antinociception, tail-flick, agonist, opioid, intracerebroventricular and clonidine
2) Confidence 0.17 Published 1995 Journal Brain Res. Section Abstract Doc Link 7552253 Disease Relevance 0 Pain Relevance 1.29
[Pharmacological properties of procaterol, a newly synthetized, specific beta 2-adrenoceptor stimulant.
Gene_expression (synthetized) of 2-adrenoceptor associated with analgesic
3) Confidence 0.03 Published 1979 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 43821 Disease Relevance 0.23 Pain Relevance 0.25

General Comments

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