INT51411

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Context Info
Confidence 0.41
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.05
Pain Relevance 5.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (EDAR) cell differentiation (EDAR) signal transduction (EDAR)
plasma membrane (EDAR)
Anatomy Link Frequency
stalk 1
EDAR (Homo sapiens)
Pain Link Frequency Relevance Heat
nalbuphine 14 100.00 Very High Very High Very High
Morphine 14 100.00 Very High Very High Very High
qutenza 18 99.80 Very High Very High Very High
narcan 12 99.20 Very High Very High Very High
fortral 18 93.84 High High
Enkephalin 10 87.08 High High
Opioid 15 83.80 Quite High
c fibre 2 79.52 Quite High
opioid receptor 4 71.68 Quite High
substance P 7 70.24 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 2 144 100.00 Very High Very High Very High
Cardiovascular Disease 9 94.36 High High
Coronary Artery Disease 17 81.40 Quite High
Diabetes Mellitus 58 50.56 Quite High
Adhesions 3 28.80 Quite Low
Helminth Infection 2 5.20 Low Low
Toxicity 10 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although lacking the olfactomedin domain and HRM motif, it contains the stalk and GPS domains present in the ?
Negative_regulation (lacking) of HRM in stalk
1) Confidence 0.41 Published 2007 Journal Toxicon Section Body Doc Link PMC2517654 Disease Relevance 0 Pain Relevance 0
It has been shown that ED5 decreases statistically significantly with increase of the length of the peptide molecule and its affinity of duration of the effects and to an increase of their affinity to delta-receptors - to prolongation of the reaction (more than150 min).
Negative_regulation (decreases) of ED5
2) Confidence 0.34 Published 2009 Journal Zh. Evol. Biokhim. Fiziol. Section Abstract Doc Link 19764635 Disease Relevance 0 Pain Relevance 0.17
The CRMP-2 peptide displays EE2 induced downregulation of expression in males at ed12 and ed17 (in average ~57%), whereas NPK is downregulated in both males and females at ed12 and ed17 (in average 50%).
Negative_regulation (downregulation) of ed17
3) Confidence 0.18 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2851587 Disease Relevance 0 Pain Relevance 0
The CRMP-2 peptide displays EE2 induced downregulation of expression in males at ed12 and ed17 (in average ~57%), whereas NPK is downregulated in both males and females at ed12 and ed17 (in average 50%).
Negative_regulation (downregulation) of ed12
4) Confidence 0.18 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2851587 Disease Relevance 0 Pain Relevance 0
Naloxone 0.3 mg kg-1 antagonized the inhibitory effect of both morphine 1.3 mg kg-1 (ED75) and nalbuphine 0.005 mg kg-1 (ED75).
Negative_regulation (effect) of ED75 associated with nalbuphine, narcan and morphine
5) Confidence 0.02 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9748706 Disease Relevance 0 Pain Relevance 1.90
Naloxone 0.3 mg kg-1 antagonized the inhibitory effect of both morphine 1.3 mg kg-1 (ED75) and nalbuphine 0.005 mg kg-1 (ED75).
Negative_regulation (effect) of ED75 associated with nalbuphine, narcan and morphine
6) Confidence 0.02 Published 1998 Journal Arzneimittelforschung Section Abstract Doc Link 9748706 Disease Relevance 0 Pain Relevance 1.92
However, treatment of ED by phosphodiesterase-5 (PDE5) inhibitors does not significantly change the level of ADMA, therefore it would not be useful for monitoring the efficacy of ED treatments.


Negative_regulation (inhibitors) of ED associated with reprotox - general 2
7) Confidence 0.01 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.05 Pain Relevance 0
The doses of capsaicin required to cause a 50% decrease in GL and Cdyn (ED50GL and ED50Cdyn respectively) were computed for each animal.
Negative_regulation (decrease) of ED50Cdyn associated with qutenza
8) Confidence 0.00 Published 1993 Journal Pulm Pharmacol Section Abstract Doc Link 7693075 Disease Relevance 0 Pain Relevance 0.72
However, combined administration of thiorphan and captopril, or SCH32615 and captopril, caused a decrease in ED50Cdyn for capsaicin, and prolonged the time during which the peak changes in GL induced by capsaicin persisted.
Negative_regulation (decrease) of ED50Cdyn associated with qutenza
9) Confidence 0.00 Published 1993 Journal Pulm Pharmacol Section Abstract Doc Link 7693075 Disease Relevance 0 Pain Relevance 0.78

General Comments

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