INT51427

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Context Info
Confidence 0.45
First Reported 1993
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 1.33
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
plasma 4
synapses 4
dorsal 2
heads 2
ventral 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 17 100.00 Very High Very High Very High
Dopamine 7 100.00 Very High Very High Very High
long-term potentiation 81 99.98 Very High Very High Very High
Inflammation 7 99.68 Very High Very High Very High
Ventral tegmentum 3 99.68 Very High Very High Very High
Eae 8 99.44 Very High Very High Very High
amygdala 303 99.14 Very High Very High Very High
Enkephalin 1 98.88 Very High Very High Very High
Hippocampus 156 97.52 Very High Very High Very High
Glutamate 9 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 99.68 Very High Very High Very High
Anxiety Disorder 164 89.52 High High
Shock 64 79.20 Quite High
Pain 1 59.64 Quite High
Amnesia 18 8.88 Low Low
Decapitation 12 5.00 Very Low Very Low Very Low
Nicotine Addiction 9 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, albeit the rapid increase in GluR1 levels induced by IA training in a synaptic plasma membrane-enriched subcellular fraction may reflect an enhancement in trafficking and membrane insertion of already formed GluR1 subunits [73], [74], it is unlikely that this is the only mechanism, for the afore mentioned reasons.
Positive_regulation (increase) of Positive_regulation (induced) of GluR1 in plasma
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03
45 h after IA training, prevent the rapid increase in GluR1 protein induced by IA training necessary for memory consolidation.
Positive_regulation (increase) of Positive_regulation (induced) of GluR1 protein
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.08 Pain Relevance 0.19
45 h after IA training, prevent the rapid increase in GluR1 protein induced by IA training necessary for memory consolidation.
Positive_regulation (induced) of Positive_regulation (increase) of GluR1 protein
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.08 Pain Relevance 0.19
Alternatively, albeit the rapid increase in GluR1 levels induced by IA training in a synaptic plasma membrane-enriched subcellular fraction may reflect an enhancement in trafficking and membrane insertion of already formed GluR1 subunits [73], [74], it is unlikely that this is the only mechanism, for the afore mentioned reasons.
Positive_regulation (induced) of Positive_regulation (increase) of GluR1 in plasma
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03
These experiments indicate that the BDNF/mTOR signaling pathway controls the learning-induced increase in GluR1 15 min or 3 h after training.
Positive_regulation (induced) of Positive_regulation (increase) of GluR1
5) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.21
Moreover, we and others have reported that a rapid post-training increase in GluR1 occurs as a consequence of an augmented protein synthesis in addition to translocation form other sub-cellular compartments [33], [48].
Positive_regulation (occurs) of Positive_regulation (increase) of GluR1
6) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.04
Following infusion, rats were trained, then sacrificed 24 hours after training as in our previous experiments, and Western blotting was performed on LA homogenates to determine whether training-induced activation of GluR1, synapsin, and synaptophysin at LA synapses is regulated by intra-LA infusion of each of these drugs (Figure 5a).
Spec (whether) Positive_regulation (induced) of Spec (whether) Positive_regulation (activation) of GluR1 in synapses associated with amygdala
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.17 Pain Relevance 0.36
Western blotting on tissue taken from around the cannula tips in the LA was then performed to determine whether training-induced activation of GluR1, synapsin, and synaptophysin at LA synapses is regulated by intra-LA infusion of each of these drugs.
Spec (whether) Positive_regulation (induced) of Spec (whether) Positive_regulation (activation) of GluR1 in synapses associated with amygdala
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.55 Pain Relevance 0.39
These data suggest that postganglionic activity may be enhanced by glutamate receptor activation during inflammation.
Spec (may) Positive_regulation (enhanced) of Positive_regulation (activation) of glutamate receptor associated with inflammation and glutamate receptor
9) Confidence 0.24 Published 1999 Journal Pain Section Abstract Doc Link 10534587 Disease Relevance 0.46 Pain Relevance 0.55
Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures.
Positive_regulation (Activation) of Positive_regulation (stimulation) of glutamate receptor associated with glutamate receptor
10) Confidence 0.24 Published 1993 Journal J. Neurochem. Section Title Doc Link 7693864 Disease Relevance 0 Pain Relevance 0.25
Preproenkephalin mRNA expression in rat dorsal striatum induced by selective activation of metabotropic glutamate receptor subtype-5.
Positive_regulation (induced) of Positive_regulation (activation) of glutamate receptor in dorsal associated with glutamate receptor and enkephalin
11) Confidence 0.14 Published 2003 Journal Synapse Section Title Doc Link 12539198 Disease Relevance 0 Pain Relevance 0.34
Induction of sensitization is the progressive increase in locomotor activity during drug treatment, and requires both dopamine and glutamate receptor activation of the ventral tegmental area (Kalivas and Alesdatter 1993; Dunn et al. 2005).
Positive_regulation (requires) of Positive_regulation (activation) of glutamate receptor in ventral associated with ventral tegmentum, dopamine, glutamate receptor and eae
12) Confidence 0.06 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2764852 Disease Relevance 0 Pain Relevance 0.57
An NMDA-receptor-mediated chemical long-term potentiation caused the accumulation of GFP-GluR1 in spine heads of control but not of shRNA-transfected, SP-deficient neurons.
Neg (not) Positive_regulation (caused) of Positive_regulation (accumulation) of GFP-GluR1 in heads associated with long-term potentiation
13) Confidence 0.01 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19176811 Disease Relevance 0 Pain Relevance 0.14

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