INT51445

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.64
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (B3GAT1) carbohydrate metabolic process (B3GAT1)
Anatomy Link Frequency
cholinergic neurons 1
spinal cord 1
brain 1
venules 1
IM-9 1
B3GAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 16 100.00 Very High Very High Very High
Neuropeptide 4 99.88 Very High Very High Very High
qutenza 19 99.60 Very High Very High Very High
substance P 14 99.52 Very High Very High Very High
primary afferent fibers 1 97.52 Very High Very High Very High
Neuritis 1 97.36 Very High Very High Very High
Dynorphin 1 96.24 Very High Very High Very High
Spinal cord 1 96.12 Very High Very High Very High
Glutamate 1 95.68 Very High Very High Very High
Neurotransmitter 4 93.84 High High
Disease Link Frequency Relevance Heat
Cancer 13 99.78 Very High Very High Very High
Adhesions 2 99.44 Very High Very High Very High
Malignant Neoplastic Disease 3 98.68 Very High Very High Very High
Neuritis 1 97.36 Very High Very High Very High
Mouth Disease 1 94.56 High High
Charcot Marie Tooth Disease 2 94.00 High High
Nociception 19 93.12 High High
Rhinitis 1 91.88 High High
Peripheral Neuropathy 1 91.32 High High
Pressure And Volume Under Development 14 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compound (+/-)-1 showed high affinity for the NK-1 receptors in human IM-9 cells with an IC(50) value of 0.22 nM.
NK-1 Binding (affinity) of in IM-9
1) Confidence 0.47 Published 2007 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 17967540 Disease Relevance 0 Pain Relevance 0.17
Substance P is a neuropeptide that binds to NK1 receptors of postcapillary venules and causes albumin and protein extravasations.
NK1 Binding (binds) of in venules associated with neuropeptide and substance p
2) Confidence 0.47 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2877239 Disease Relevance 0.76 Pain Relevance 0.65
Several studies on myelin proteins in the PNS have indicated that the L2/HNK-1 epitope, which is believed to be both a ligand for cellular adhesion and a target for autoimmune monoclonal IgM neuritis, may be found on heretofore unidentified proteins with a molecular mass of 19-28 kDa.
HNK-1 Binding (ligand) of in HNK-1 associated with neuritis and adhesions
3) Confidence 0.36 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 7693873 Disease Relevance 0.65 Pain Relevance 0.10
Immunohistochemical studies performed in two cases showed positivity of the tumor cells for keratin, Leu 7, and synaptophysin, and focal chromogranin positivity in one.
Leu 7 Binding (keratin) of associated with cancer
4) Confidence 0.36 Published 1999 Journal Hum. Pathol. Section Abstract Doc Link 10374770 Disease Relevance 1.00 Pain Relevance 0.07
There must be an intimate interaction of i.t. high-dose morphine with tachykinin neurokinin 1 (NK1) receptors and multiple sites on the N-methyl-D-aspartate (NMDA) receptor complex in the dorsal spinal cord.
NK1 Binding (interaction) of in spinal cord associated with spinal cord and morphine
5) Confidence 0.36 Published 2005 Journal Neurotoxicology Section Abstract Doc Link 15936820 Disease Relevance 0.75 Pain Relevance 1.77
Tachykinins, probably released in small amounts by capsaicin, act by activating receptors of the NK1, NK2 and NK3 type, most probably located on intrinsic cholinergic neurons, which in turn release ACh to produce the final excitatory motor response.
NK1 Binding (receptors) of in cholinergic neurons associated with qutenza
6) Confidence 0.17 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10543438 Disease Relevance 0 Pain Relevance 0.77
A lead compound which had sub-micromolar affinity for the rabbit NK1 receptor but negligible affinity for rat NK1 receptors, 3a, was discovered by directed screening. 2-Substitution in the ring of the benzylthiourea substituent in the initial lead was found to be important, and halogens (Cl, Br) in this position were found to improve affinity for the human receptor.
NK1 Binding (affinity) of
7) Confidence 0.13 Published 1998 Journal J. Med. Chem. Section Abstract Doc Link 9703462 Disease Relevance 0.07 Pain Relevance 0.22
Immunohistochemically the tumor was positive to NSE and slightly positive to keratin, but negative to LCA, L26, UCLH-1, EMA, Leu7, and chromogranin, suggesting a malignant tumor derived from neuroendocrine tissue.
Leu7 Binding (negative) of associated with malignant neoplastic disease and cancer
8) Confidence 0.09 Published 1998 Journal Lung Cancer Section Abstract Doc Link 9869108 Disease Relevance 0.97 Pain Relevance 0.17
Following a single intraperitoneal dose, radioactive labeled casopitant ([14C] casopitant) was rapidly absorbed, with plasma and brain concentrations being approximately equal at two hours post-dosing. [14C] casopitant was found in the brain as the parent compound and two major oxidative metabolites (M1 and M2), accounting for approximately 76%, 19%, and 3% of the radioactivity, respectively; suggesting that the pharmacologic activity of casopitant in the ferret is largely attributable to the parent compound.26 An in vitro receptor binding affinity study describes, that casopitant possesses a high affinity for brain NK1 receptors in the ferret.26
NK1 Binding (affinity) of in brain
9) Confidence 0.07 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697542 Disease Relevance 0.45 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox