INT51458

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 29
Total Number 29
Disease Relevance 12.64
Pain Relevance 8.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) nucleolus (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 26
leukocyte 10
coronary sinus 2
Selp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diclofenac 42 100.00 Very High Very High Very High
Inflammation 20 100.00 Very High Very High Very High
adenocard 6 100.00 Very High Very High Very High
anesthesia 15 99.98 Very High Very High Very High
lidocaine 6 99.82 Very High Very High Very High
Angina 39 99.54 Very High Very High Very High
agonist 9 99.20 Very High Very High Very High
antagonist 15 98.88 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 2 94.20 High High
cva 3 92.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 30 100.00 Very High Very High Very High
Adhesions 23 100.00 Very High Very High Very High
Injury 17 100.00 Very High Very High Very High
Acute Coronary Syndrome 10 99.98 Very High Very High Very High
Disease 6 99.80 Very High Very High Very High
Cv General 3 Under Development 36 99.54 Very High Very High Very High
Myocardial Infarction 12 99.40 Very High Very High Very High
Coronary Artery Disease 6 99.28 Very High Very High Very High
Sepsis 3 99.12 Very High Very High Very High
Thrombosis 6 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that lidocaine produced a concentration-dependent inhibition of P-selectin expression and PLA.
Negative_regulation (inhibition) of Gene_expression (expression) of P-selectin
1) Confidence 0.57 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Body Doc Link 19527965 Disease Relevance 0 Pain Relevance 0
Sevoflurane anesthesia attenuates adenosine diphosphate-induced P-selectin expression and platelet-leukocyte conjugate formation.
Negative_regulation (attenuates) of Gene_expression (expression) of P-selectin in leukocyte associated with adenocard and anesthesia
2) Confidence 0.57 Published 2004 Journal Anesth. Analg. Section Title Doc Link 15385361 Disease Relevance 0.18 Pain Relevance 0.48
Sevoflurane inhibited platelet P-selectin expression.
Negative_regulation (inhibited) of Gene_expression (expression) of P-selectin in platelet
3) Confidence 0.57 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385361 Disease Relevance 0.14 Pain Relevance 0.58
Expression of P-selectin was reduced by diclofenac and unaffected by enalapril, even when combined with diclofenac.
Negative_regulation (reduced) of Gene_expression (Expression) of P-selectin associated with diclofenac
4) Confidence 0.51 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14716214 Disease Relevance 0.57 Pain Relevance 0.60
Losartan has an antimigratory effect, reducing leukocyte migration by reducing ICAM-1 and P-selectin expression.
Negative_regulation (reducing) of Gene_expression (expression) of P-selectin in leukocyte
5) Confidence 0.50 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16044031 Disease Relevance 0.24 Pain Relevance 0.35
All the treatments tested reduced the number of rollers, adherent and migrated leukocytes, and the expression of endothelial intercellular adhesion molecule-1 and P-selectin.
Negative_regulation (reduced) of Gene_expression (expression) of P-selectin in leukocytes associated with adhesions
6) Confidence 0.50 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16044031 Disease Relevance 0.57 Pain Relevance 0.56
A significantly reduced P-selectin expression was found in the long-term preservation group compared with the short-term group.
Negative_regulation (reduced) of Gene_expression (expression) of P-selectin
7) Confidence 0.46 Published 2003 Journal Clin Transplant Section Abstract Doc Link 14703928 Disease Relevance 0.40 Pain Relevance 0.17
Reduced P-selectin expression on circulating platelets after prolonged cold preservation in renal transplantation.
Negative_regulation (Reduced) of Gene_expression (expression) of P-selectin in platelets
8) Confidence 0.46 Published 2003 Journal Clin Transplant Section Title Doc Link 14703928 Disease Relevance 0.64 Pain Relevance 0.20
Reduced expression of P-selectin on circulating platelets may be an indicator of I/R injury after prolonged kidney graft preservation.
Negative_regulation (Reduced) of Gene_expression (expression) of P-selectin in platelets associated with injury
9) Confidence 0.46 Published 2003 Journal Clin Transplant Section Abstract Doc Link 14703928 Disease Relevance 0.15 Pain Relevance 0.07
Lidocaine priming reduces ADP-induced P-selectin expression and platelet-leukocyte aggregation.
Negative_regulation (reduces) of Gene_expression (expression) of P-selectin in leukocyte associated with lidocaine
10) Confidence 0.42 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Title Doc Link 19527965 Disease Relevance 0.53 Pain Relevance 0.28
Platelet P-selectin expression and PLA formation have been reported to be potential markers of inflammatory diseases such as sepsis, thrombosis, myocardial ischemic disorders and stroke.
Negative_regulation (markers) of Gene_expression (expression) of P-selectin in Platelet associated with inflammation, stroke, disease, lidocaine, thrombosis and sepsis
11) Confidence 0.42 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 19527965 Disease Relevance 0.59 Pain Relevance 0.27
In both AMI and UA, S-nitrosoglutathione reduced P-selectin (P < .001) and glycoprotein IIb/IIIa (P < .05) expression, as did glyceryl trinitrate (P < .02 and P < .01, respectively).
Negative_regulation (reduced) of Gene_expression (expression) of P-selectin associated with angina and myocardial infarction
12) Confidence 0.40 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8548426 Disease Relevance 1.59 Pain Relevance 0.89
Expression of P-selectin was reduced by diclofenac and unaffected by enalapril, even when combined with diclofenac.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (Expression) of P-selectin associated with diclofenac
13) Confidence 0.37 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14716214 Disease Relevance 0.58 Pain Relevance 0.61
Anti-P-selectin and anti-E-selectin produced only small (approximately 35%), but statistically significant, reductions of mucosal injury, but only anti-P-selectin significantly affected indomethacin-induced leukocyte adherence (by approximately 50%).
Negative_regulation (reductions) of Gene_expression (produced) of anti-P-selectin in leukocyte associated with injury
14) Confidence 0.36 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7694504 Disease Relevance 0.91 Pain Relevance 0.26
GPIIb/IIIa and P-selectin expression on circulating platelets were significantly decreased in the long and the short-term graft preservation group compared with healthy volunteers.
Negative_regulation (decreased) of Gene_expression (expression) of P-selectin in platelets
15) Confidence 0.33 Published 2003 Journal Clin Transplant Section Abstract Doc Link 14703928 Disease Relevance 0.45 Pain Relevance 0.19
We have found that surface expression of P-selectin on platelets in whole blood from PTCA patients upon thrombin treatment was significantly reduced, as compared with control platelets from healthy subjects.
Negative_regulation (reduced) of Gene_expression (expression) of P-selectin in platelets
16) Confidence 0.24 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 11122546 Disease Relevance 0.09 Pain Relevance 0.20
[Decreased plasma soluble P-selectin level in coronary sinus after successful coronary angioplasty in patients with unstable angina].
Negative_regulation ([Decreased) of Gene_expression (level) of P-selectin in coronary sinus associated with angina
17) Confidence 0.20 Published 1999 Journal J Cardiol Section Title Doc Link 10354952 Disease Relevance 0.43 Pain Relevance 0.33
NO may directly attenuate the activation of platelet, preventing the expression of P-selectin, secretion of platelet granules, intracellular calcium flux, as well as binding of glycoprotein IIb/IIIa to fibrinogen, but could also result in severe detrimental consequences [50], particularly in hemorrhage developed following CPA treatment.
Negative_regulation (preventing) of Gene_expression (expression) of P-selectin in platelet associated with cva
18) Confidence 0.14 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.29 Pain Relevance 0.07
Platelet degranulation (P-selectin expression) is also impaired in patients with coronary artery disease, but only in comparison with younger subjects, not age-matched controls.
Negative_regulation (impaired) of Gene_expression (expression) of P-selectin in Platelet associated with coronary artery disease
19) Confidence 0.13 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351370 Disease Relevance 0.35 Pain Relevance 0.16
When stimulated with agonists, patients' platelets had significantly decreased fibrinogen binding (P < .03) but no difference in P-selectin expression compared with the age-matched group.
Negative_regulation (decreased) of Gene_expression (expression) of P-selectin in platelets associated with agonist
20) Confidence 0.13 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351370 Disease Relevance 0.27 Pain Relevance 0.25

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