INT5146

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Context Info
Confidence 0.81
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 12.50
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PPBP) extracellular region (PPBP)
Anatomy Link Frequency
platelet 23
blood 2
plasma 1
chest 1
eosinophils 1
PPBP (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 20 99.46 Very High Very High Very High
anesthesia 6 99.08 Very High Very High Very High
epidural 4 98.86 Very High Very High Very High
Angina 41 97.88 Very High Very High Very High
local anesthetic 6 97.74 Very High Very High Very High
analgesia 2 96.52 Very High Very High Very High
Inflammation 28 95.98 Very High Very High Very High
addiction 1 95.58 Very High Very High Very High
Pain 9 95.32 Very High Very High Very High
corticosteroid 4 94.80 High High
Disease Link Frequency Relevance Heat
Coagulation Disorder 5 100.00 Very High Very High Very High
Vasculitis 6 99.36 Very High Very High Very High
Coronary Artery Disease 15 99.28 Very High Very High Very High
Syndrome 3 98.68 Very High Very High Very High
Death 6 98.64 Very High Very High Very High
Myalgia 3 98.50 Very High Very High Very High
Eosinophilia 4 98.34 Very High Very High Very High
Angina 6 97.88 Very High Very High Very High
Myocardial Infarction 49 97.68 Very High Very High Very High
Diabetes Mellitus 42 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of platelet aggregation was associated with a significant decrease in beta-thromboglobulin secretion.
Localization (secretion) of beta-thromboglobulin in platelet
1) Confidence 0.81 Published 1989 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2529732 Disease Relevance 0 Pain Relevance 0.14
In contrast, pipecoloxylidide had no effect on platelet aggregation or the beta-thromboglobulin release.
Localization (release) of beta-thromboglobulin in platelet
2) Confidence 0.81 Published 1989 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2529732 Disease Relevance 0 Pain Relevance 0.14
Hemodynamics, platelet count, platelet aggregation to adenosine diphosphate, and release of beta-thromboglobulin were measured before tirofiban infusion, before heparin, after heparin before bypass, after 5 and 55 minutes of bypass, after protamine, and 60 minutes after protamine.
Localization (release) of beta-thromboglobulin in platelet
3) Confidence 0.79 Published 1997 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 9011688 Disease Relevance 0.08 Pain Relevance 0
Platelet ADP-induced aggregation (ADP-agg.) and secretion of beta-thromboglobulin (beta-TG) were measured in the effluent blood as well as systemically.
Localization (secretion) of beta-TG in blood
4) Confidence 0.78 Published 1995 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8607308 Disease Relevance 0.28 Pain Relevance 0.45
At 120 minutes, lidocaine (100 mumol/L), which inhibits neutrophil activation, delayed release of lactoferrin (1.33 +/- 0.26 micrograms/mL) and markedly inhibited release of elastase (0.24 +/- 0.05 microgram/mL) but did not inhibit release of beta-TG antigen (5.66 micrograms/mL at 120 minutes).
Localization (release) of beta-TG in neutrophil associated with lidocaine
5) Confidence 0.78 Published 1987 Journal Blood Section Abstract Doc Link 2947645 Disease Relevance 0 Pain Relevance 0.10
Platelet activation is manifested by a release into circulation of the components of granules, including beta-thromboglobulin (beta-TG) - a marker of platelet activation in vivo.
Localization (release) of beta-TG in platelet
6) Confidence 0.78 Published 2003 Journal Kardiol Pol Section Abstract Doc Link 14556011 Disease Relevance 0.37 Pain Relevance 0.16
Circulating levels of beta-thromboglobulin (beta-TG), as well as thrombin (clotting)-stimulated platelet release of thromboxane, were also determined.
Localization (release) of beta-TG in platelet associated with coagulation disorder
7) Confidence 0.78 Published 1992 Journal Am. J. Hematol. Section Abstract Doc Link 1533087 Disease Relevance 0.66 Pain Relevance 0.09
It is concluded that plasma local anesthetic concentrations achieved during normal maternal epidural anesthesia do not affect M or N platelet aggregation or beta-tg release.
Localization (release) of beta-tg in platelet associated with anesthesia, epidural and local anesthetic
8) Confidence 0.68 Published 1989 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2529733 Disease Relevance 0 Pain Relevance 0.44
Effects of gallopamil on epinephrine and norepinephrine plasmatic levels and on TxB2 and beta-tg release in patients with coronary artery disease during adrenergic stimulus with cold pressor test.
Localization (release) of beta-tg in coronary artery associated with coronary artery disease
9) Confidence 0.68 Published 1995 Journal Pharmacol. Res. Section Title Doc Link 8668647 Disease Relevance 0.45 Pain Relevance 0.47
RESULTS: High-dose tirofiban completely prevents platelet loss during cardiopulmonary bypass. beta-Thromboglobulin release and sensitivity to adenosine diphosphate are significantly less than control at the end of bypass in all tirofiban groups.
Localization (release) of beta-Thromboglobulin in platelet
10) Confidence 0.64 Published 1997 Journal J. Thorac. Cardiovasc. Surg. Section Body Doc Link 9011688 Disease Relevance 0.05 Pain Relevance 0
Platelet function was assessed by filtragometry ex vivo (reflecting platelet aggregability), by measuring platelet secretion (beta-thromboglobulin and platelet factor 4 levels in plasma), and by Born aggregometry in vitro.
Localization (secretion) of beta-thromboglobulin in Platelet
11) Confidence 0.63 Published 1997 Journal Eur. Heart J. Section Abstract Doc Link 9152651 Disease Relevance 0.71 Pain Relevance 0.38
Lidocaine (10 to 20 microgram/ml), however, prevented the rise in N-acetyl-beta-glucosaminidase activity and diminished acid phosphatase levels without altering secretion of LA-PF4.
Localization (secretion) of LA-PF4 associated with lidocaine
12) Confidence 0.56 Published 1982 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 6806546 Disease Relevance 0.06 Pain Relevance 0.19
Platelet inhibition prevented release of LA-PF4 and reduced acid phosphatase levels, but failed to alter the levels of N-acetyl-beta-glucosaminidase.
Localization (release) of LA-PF4 in Platelet
13) Confidence 0.56 Published 1982 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 6806546 Disease Relevance 0 Pain Relevance 0.16
Platelet activation is manifested by a release into circulation of the components of granules, including beta-thromboglobulin (beta-TG) - a marker of platelet activation in vivo.
Localization (release) of beta-thromboglobulin in platelet
14) Confidence 0.51 Published 2003 Journal Kardiol Pol Section Abstract Doc Link 14556011 Disease Relevance 0.37 Pain Relevance 0.16
The failure of platelet inhibitors to block the increase in N-acetyl-beta-glucosaminidase, and the efficacy of lidocaine to do so without altering LA-PF4 secretion, suggest that leukocytes, not platelets, are the primary source of this lysosomal enzyme.
Localization (secretion) of LA-PF4 in platelet associated with lidocaine
15) Confidence 0.49 Published 1982 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 6806546 Disease Relevance 0.07 Pain Relevance 0.19
The effects of bupivacaine (B), lidocaine (L) and 2-chloroprocaine (C) on maternal (M) and neonatal (N) platelet function were studied using in vitro beta-thromboglobulin (beta-tg) release (radioimmunoassay), and in vitro platelet aggregation.
Localization (release) of beta-thromboglobulin in platelet associated with lidocaine
16) Confidence 0.44 Published 1989 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2529733 Disease Relevance 0 Pain Relevance 0.22
The plasma concentration of beta-thromboglobulin (BTG), a platelet-specific protein released during platelet aggregation, is considered a sensitive marker of in vivo platelet activity.
Localization (released) of beta-thromboglobulin in platelet
17) Confidence 0.41 Published 1982 Journal Am. J. Cardiol. Section Abstract Doc Link 6183969 Disease Relevance 0.28 Pain Relevance 0
Therefore, we have used adenoviral overexpression to demonstrate NF-kappaB and IKK2 dependence of key inflammatory genes, including intercellular adhesion molecule (ICAM)-1, cyclooxygenase-2, IL-6, IL-8, granulocyte macrophage-colony-stimulating factor (GM-CSF), regulated on activation normal T cell expressed and secreted (RANTES), monocyte chemotactic protein-1 (MCP-1), growth-regulated oncogene-alpha (GROalpha), neutrophil-activating protein-2 (NAP-2), and epithelial neutrophil activating peptide 78 (ENA-78) in primary human airways smooth muscle cells.
Localization (secreted) of neutrophil-activating protein-2 in T cell associated with addiction, inflammation and adhesions
18) Confidence 0.37 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 1.23 Pain Relevance 0.52
Intracoronary platelet release of beta-thromboglobulin (BTG) was measured in 18 patients with a history of chest pain by analysis of aortic and coronary sinus blood samples in rest and during atrial pacing.
Localization (release) of beta-thromboglobulin in chest associated with angina
19) Confidence 0.37 Published 1983 Journal Thromb. Haemost. Section Abstract Doc Link 6221435 Disease Relevance 0.26 Pain Relevance 0.10
Patients prone to vasospastic responses to CT exhibited platelet activation along with beta-thromboglobulin release and formation of spontaneous platelet aggregates.
Localization (release) of beta-thromboglobulin in platelet
20) Confidence 0.35 Published 1992 Journal Kardiologiia Section Abstract Doc Link 1287314 Disease Relevance 0.17 Pain Relevance 0.07

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