INT51460

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Context Info
Confidence 0.52
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 10.18
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) cell adhesion (Sele) molecular_function (Sele)
cellular_component (Sele)
Anatomy Link Frequency
lung 4
macrophage 2
artery 2
leukocyte 2
Sele (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 27 99.18 Very High Very High Very High
Inflammation 158 96.92 Very High Very High Very High
spinal inflammation 2 96.24 Very High Very High Very High
Angina 9 95.84 Very High Very High Very High
vagus nerve 6 91.40 High High
Arthritis 93 89.84 High High
Infliximab 64 81.60 Quite High
cytokine 36 81.48 Quite High
cINOD 4 75.00 Quite High
psoriasis 54 66.48 Quite High
Disease Link Frequency Relevance Heat
Injury 11 99.52 Very High Very High Very High
Hypersensitivity 258 99.38 Very High Very High Very High
Adhesions 48 99.20 Very High Very High Very High
Rheumatoid Arthritis 27 99.18 Very High Very High Very High
Uveitis 9 98.76 Very High Very High Very High
INFLAMMATION 116 96.92 Very High Very High Very High
Disease 30 96.72 Very High Very High Very High
Low Back Pain 2 96.24 Very High Very High Very High
Cv General 3 Under Development 9 95.84 Very High Very High Very High
Pneumonia 63 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogen protects against cellular infiltration by reducing the expressions of E-selectin and IL-6 in endotoxin-induced uveitis.
Negative_regulation (reducing) of Gene_expression (expressions) of E-selectin associated with uveitis
1) Confidence 0.52 Published 1999 Journal J. Immunol. Section Title Doc Link 10384138 Disease Relevance 1.00 Pain Relevance 0.16
Interestingly, estradiol prevents artery wall thickness by mechanism involving a diminished E-selectin expression in postmenopausal women [41].
Negative_regulation (diminished) of Gene_expression (expression) of E-selectin in artery
2) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.51 Pain Relevance 0.30
Anti-P-selectin and anti-E-selectin produced only small (approximately 35%), but statistically significant, reductions of mucosal injury, but only anti-P-selectin significantly affected indomethacin-induced leukocyte adherence (by approximately 50%).
Negative_regulation (reductions) of Gene_expression (produced) of anti-E-selectin in leukocyte associated with injury
3) Confidence 0.33 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7694504 Disease Relevance 0.90 Pain Relevance 0.26
Lungs of OVx-allergic rats upon estradiol treatment decreased the E-selectin expression to levels close to those found in lung of Sham-OVx allergic rats.
Negative_regulation (decreased) of Gene_expression (expression) of E-selectin in lung associated with hypersensitivity
4) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.03 Pain Relevance 0
Indeed, E-selectin expression of lung was decreased in estradiol treated OVx allergic rats.
Negative_regulation (decreased) of Gene_expression (expression) of E-selectin in lung associated with hypersensitivity
5) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2936382 Disease Relevance 1.21 Pain Relevance 0.27
In renal tissue vagal stimulation significantly decreased the expression of E-selectin, IL1beta and ITGA6.
Negative_regulation (decreased) of Gene_expression (expression) of E-selectin
6) Confidence 0.28 Published 2010 Journal Am. J. Transplant. Section Abstract Doc Link 20055812 Disease Relevance 0.99 Pain Relevance 0.39
Levels of expression of P-selectin, E-selectin, and intercellular adhesion molecule-1 in coronary atherectomy specimens from patients with stable and unstable angina pectoris.
Negative_regulation (Levels) of Gene_expression (expression) of E-selectin associated with angina and adhesions
7) Confidence 0.03 Published 1997 Journal Am. J. Cardiol. Section Title Doc Link 9070552 Disease Relevance 1.54 Pain Relevance 0.72
Decreased expression of both E-selectin and VCAM-1 was observed in the synovial tissue as well, although the change did not reach statistical significance.


Negative_regulation (Decreased) of Gene_expression (expression) of E-selectin
8) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464872 Disease Relevance 0.24 Pain Relevance 0.04
Mean E-selectin expression was reduced by 95% at week 4 compared with baseline (P ?
Negative_regulation (reduced) of Gene_expression (expression) of E-selectin
9) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464872 Disease Relevance 0.27 Pain Relevance 0.03
In the previous study [3], an increase in vessel number was also a distinguishing feature from RA, as were lower macrophage numbers and a reduction in E-selectin expression.
Negative_regulation (reduction) of Gene_expression (expression) of E-selectin in macrophage associated with rheumatoid arthritis
10) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174969 Disease Relevance 1.49 Pain Relevance 0.72

General Comments

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